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2009 Fiscal Year Final Research Report

Development of newly immuno-viral therapy incorporated in tumor microenvironment theory for gastrointestinal cancer

Research Project

  • PDF
Project/Area Number 19390341
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionWakayama Medical University

Principal Investigator

YAMAUE Hiroki  Wakayama Medical University, 医学部, 教授 (20191190)

Co-Investigator(Kenkyū-buntansha) NAKAMORI Mikihito  和歌山県立医科大学, 医学部, 講師 (10322372)
IWAHASHI Makoto  和歌山県立医科大学, 医学部, 講師 (70244738)
NAKAMURA Masaki  和歌山県立医科大学, 医学部, 助教 (80364090)
Project Period (FY) 2007 – 2009
Keywords消化器癌 / 免疫療法 / 腫瘍抗原ペプチド / ウイルス療法
Research Abstract

Vascular endothelial growth factor receptor 2 (VEGFR2) is an essential factor in tumor angiogenesis and in the growth of pancreatic cancer. Immunotherapy using epitope peptide for VEGFR2 (VEGFR2-169) that we identified previously is expected to improve the clinical outcome. Therefore, a phase I clinical trial combining of VEGFR2-169 with gemcitabine was conducted for patients with advanced pancreatic cancer. Patients with metastatic and unresectable pancreatic cancer were eligible for the trial. In addition, we developed newly oncolytic herpes simplex viruses (HSV). This virus can produce human thrombospondin-1 (TSP-1) and induce apoptosis for human gastric cancer cell lines. In vivo experiments, our virus could suppress tumor angiogenesis.

  • Research Products

    (8 results)

All 2010 2009 2008 Other

All Journal Article (4 results) (of which Peer Reviewed: 1 results) Presentation (2 results) Book (1 results) Remarks (1 results)

  • [Journal Article] I clinical trial using peptide vaccine for human vascular endothelial growth factor receptor 2 in combination with gemcitabine for patients with advanced pancreatic cancer.2010

    • Author(s)
      Miyazawa M, Ohsawa R, Tsunoda T, Hirono S, Kawai M, Tani M, Nakamura Y, Yamaue H. Phase
    • Journal Title

      Cancer Sci. 101

      Pages: 433-439

    • Peer Reviewed
  • [Journal Article] 腫瘍溶解ウイルスの癌治療への応用2009

    • Author(s)
      中森幹人, 山上裕機
    • Journal Title

      Biotherapy 23

      Pages: 409-415

  • [Journal Article] 次世代バイオセラピィの分子標的2008

    • Author(s)
      山上裕機
    • Journal Title

      Biotherapy 22

      Pages: 2 15-219

  • [Journal Article] Taxaneの作用機序を標的としたarming oncolytic herpes virusの改良2008

    • Author(s)
      中森幹人
    • Journal Title

      Biotherapy 22

      Pages: 227-232

  • [Presentation] 膵臓治療戦略-RCT結果に基づいた手術術式の開発と集学的治療2010

    • Author(s)
      山上裕機
    • Organizer
      第110回日本外科学会定期学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2010-04-08
  • [Presentation] 膵臓外科のArtとScience2008

    • Author(s)
      山上裕機
    • Organizer
      第63回日本消化器外科学会総会
    • Place of Presentation
      札幌
    • Year and Date
      2008-07-17
  • [Book] 飯田橋パピルス分子細胞治療フロンティア2010(分担執筆)2010

    • Author(s)
      山上裕機,宮澤基樹,中森幹人
    • Total Pages
      232
  • [Remarks]

    • URL

      http://www.wakayama-med.ac.jp/med/2nd-surgery/

URL: 

Published: 2011-06-18   Modified: 2016-04-21  

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