2009 Fiscal Year Final Research Report
Development of autologous tissue heart valves constructed by in vivo tissue engineering.
| Project/Area Number |
19390368
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
KANDA Keiichi Kyoto Prefectural University of Medicine, 医学研究科, 講師 (60295649)
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| Co-Investigator(Kenkyū-buntansha) |
TAKAMIZAWA Keiichi 国立循環器病センター研究所, 生体工学部, 室員 (10163312)
OHBA Keikichi 関西大学, 工学部, 教授 (30029186)
TAJIKAWA Tsutomu 関西大学, 工学部, 講師 (80351500)
WATANABE Taiji 京都府立医科大学, 医学研究科, 助教 (20448723)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 自家組織 / 心臓生体弁 / 再生医療 / 組織工学 / in vivo |
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| Research Abstract |
We have developed the autologous tissue heart valves (Biovalves) constructed by the simple, safe and economical in vivo tissue engineering without any use of specially clean facilities nor complicated procedures. A tapered silicone mold was covered by a crown-shaped PU sponge scaffold, which was embedded in the subcutaneous space of the Japan white rabbit for 4 weeks. After removal of the silicone mold, tri-leaflet valvular shaped autologous tissues were formed. In the flow circuit, smooth valvular movements were observed. Their flow volume pattern was very close to that of native rabbit aortic valves. The latest model was successfully implanted to the pulmonary valves in the allogeneic beagle model as a pilot experiment. In vivo tissue engineered "Biovalves" could be idealistic autologous heart valve prostheses with potentiality replacing the short-coming Homografts.
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Research Products
(20 results)
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[Journal Article] Development of a completely autologous valved-conduit with the sinus of valsalva (BIOVALVE) using in-body tissue architecture technology: a pilot study in pulmonary valve replacement in a beagle model.2010
Author(s)
Yamanami M, Yahata Y, Uechi M, Fujiwara M, Ishibashi-Ueda H, Kanda K, Watanabe T, Tajikawa T, Ohba K, Yaku H, Nakayama Y.
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Journal Title
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[Presentation] STRUCTURAL IMPROVEMENT IN AUTOLOGOUS TISSUE HEART VALVES (BIOVALVES) CONSTRUCTED BY SYMPLE IN VIVO TISSUE ENGINEERING.2008
Author(s)
K. Kanda, K Hayashida, M Onoyama, T Tajikawa, H Ishida, Y Yahata, K Ooba, T Ooie, Y Okamoto, Y Nemoto, H Ueda, T Watanabe, M Yamanami, H Yaku, Y Nakayama
Organizer
European Society for Artificial Organs: Annual Meeting 2008
Place of Presentation
ジュネーブ(スイス)
Year and Date
20080903-20080906
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[Presentation] Highlights from the Japanese Society for Artificial Organs. New approach in tissue engineering-A Simple, Safe, Practical and Economical Autologous Tissue Regeneration Technique in vivo-2008
Author(s)
K. Kanda, O. Sakai, K. Hayashida, T. Watanabe, M. Yamanami, M. Onoyama, T. Tajikawa, H. Ishida, Y. Yahata, K. Ohba, T. Ooie, Y. Okamoto, Y. Nemoto, H. Ueda, H. Yaku, Y. Nakayama
Organizer
European Society for Artificial Organs: Annual Meeting 2008
Place of Presentation
ジュネーブ(スイス)
Year and Date
20080903-20080906
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[Presentation] RECENT ADVANCES IN AUTOLOGOUS TISSUE HEART VALVES "BIOVALVES": IMPROVED SCAFFOLDS FOR OPTIMAL TISSUE FORMATION AND VALUVULAR FUNCTIONS.2008
Author(s)
K. Kanda, K Hayashida, M Onoyama, T Tajikawa, H Ishida, Y Yahata, K Ooba, T Ooie, Y Okamoto, Y Nemoto, H Ueda, T Watanabe, M Yamanami, H Yaku, Y Nakayama
Organizer
14th World Congress on Heart Disease
Place of Presentation
トロント(カナダ)
Year and Date
20080726-20080729
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