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2008 Fiscal Year Final Research Report

Inhibition of metastasis and tetraspanin expression by the human monoclonal antibody directed to CD151 and RNA interference

Research Project

  • PDF
Project/Area Number 19390369
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Thoracic surgery
Research InstitutionTazuke Kofukai Medical Research Institute

Principal Investigator

MIYAKE Masayuki  Tazuke Kofukai Medical Research Institute, 医学研究所・第1研究部, 研究員 (90250076)

Co-Investigator(Kenkyū-buntansha) OMASA Mitsugu  財団法人田附興風会, 医学研究所・第1研究部, 研究員 (80379049)
Co-Investigator(Renkei-kenkyūsha) MITSUDOMI Tetsuya  愛知県がんセンター, 研究所, 研究員 (70209807)
Project Period (FY) 2007 – 2008
Keywords転移促進遺伝子 / CD151 / MRP1 / CD9 / KAI1 / CD82 / テトラスパニン / 癌転移
Research Abstract

siRNAで、CD151を中心としたインテグリン・テトラスパニン複合構成体を抑制、崩壊させることに成功した。さらに、CD151のノックアウトを行った後にMRP-1/CD9、KAI1/CD82の遺伝子治療によるカクテル療法を細胞株で行い、in vitroレベルでは、成功した。しかし、これらの細胞株を、ヌードマウスに生着させ、in vivoで数度のカクテル療法を行ったが、失敗に終わった。スキッドマウスでは、成功したので、この原因は、遺伝子導入におけるウイルスベクターの使用によるウイルス抗原に対する抗体の産生などによると考えた

  • Research Products

    (10 results)

All 2008 2007

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (2 results)

  • [Journal Article] Stepwise examination for differential diagnosis of primary lung cancer and breast cancer relapse presenting as a solitary pulmonary nodule in patients after mastectomy2008

    • Author(s)
      Okasaka, T., Usami, N., Mitsudomi, T., Yatabe, Y., Matsuo, K., and Yokoi, K
    • Journal Title

      J Surg Oncol. 1 98(7)

      Pages: 510-514

    • Peer Reviewed
  • [Journal Article] Predictors of survival in patients with bone metastasis of lung cancer2008

    • Author(s)
      Sugiura, H., Yamada, K., Sugiura, T., Hida, T., and Mitsudomi, T
    • Journal Title

      Clin Orthop Relat Res 466(3)

      Pages: 729-36

    • Peer Reviewed
  • [Journal Article] Adenoviral Transduction of MRP-1/CD9 and KAI1/CD82 Inhibits Lymph Node Metastasis in Orthotopic Lung Cancer Model2007

    • Author(s)
      Takeda, T., Hattori, N., Tokuhara, T., Nishimura, Y., Yokoyama, M., and Miyake, M
    • Journal Title

      Cancer Res 67

      Pages: 1744-1749

    • Peer Reviewed
  • [Journal Article] Clinicopathological significance of aminopeptidase N/CD13 expression in human gastric carcinoma2007

    • Author(s)
      Kawamura, J., Shimada, Y., Kitaichi, H., Komoto, I., Hashimoto, Y., Kaganoi, J., Miyake, M., Yamasaki, S., Kondo, K., Imamura, M
    • Journal Title

      Hepatogastroenterology 54(73)

      Pages: 36-40

    • Peer Reviewed
  • [Journal Article] Lineage-specific dependency of lung adenocarcinomas on the lung development regulator2007

    • Author(s)
      Tanaka, H., Yanagisawa, K., Shinjo, K., Taguchi, A., Maeno, K., Tomida, S., Shimada, Y., Osada, H., Kosaka, T., Matsubara, H., Mitsudomi, T., Sekido, Y., Tanimoto, M., Yatabe, Y., and Takahashi, T.
    • Journal Title

      TTF-1Cancer Res. 1 67(13)

      Pages: 6007-11

    • Peer Reviewed
  • [Journal Article] A 25-signal proteomic signature and outcome for patients with resected non-small-cell lung cance2007

    • Author(s)
      Yanagisawa, K., Tomida, S., Shimada, Y., Yatabe, Y., Mitsudomi, T., and Takahashi, T
    • Journal Title

      J Natl Cancer Inst. 6 99(11)

      Pages: 858-67

    • Peer Reviewed
  • [Journal Article] Controversy about small peripheral lung adenocarcinomas: how should we manage them?2007

    • Author(s)
      Fukui, T., Sakakura, N., Mori, S., Hatooka, S., Shinoda, M., Yatabe, Y., and Mitsudomi, T
    • Journal Title

      J Thorac Oncol 2(6)

      Pages: 546-52

    • Peer Reviewed
  • [Journal Article] Impact of one-carbon metabolism-related gene polymorphisms on risk of lung cancer in Japan: a case control study2007

    • Author(s)
      Suzuki, T., Matsuo, K., Hiraki, A., Saito, T., Sato, S., Yatabe, Y., Mitsudomi, T., Hida, T., Ueda, R., Tajima, K
    • Journal Title

      Carcinogenesis 28(8)

      Pages: 1718-25

    • Peer Reviewed
  • [Presentation] Gene Transduction Of RhoA And ROCK-Dominant Negative Form Suppresses Lung Metastasis Of Melanoma2008

    • Author(s)
      Takeda,T. Hattori,N. Tokuhara,T. Takeda,S.M. Miyake
    • Organizer
      The 2008 International Conference of American Thoracic Society (ATS)
    • Place of Presentation
      Toronto, Canada
    • Year and Date
      20080516-21
  • [Presentation] Suppression of metastasis by human-type monoclonal antibody recognizing aminopeptidase N2007

    • Author(s)
      Tokuhara, T., Hirai, T., Miyake, M
    • Organizer
      The Annual Meeting 2007 of American Association for Cancer Research
    • Place of Presentation
      Los Angeles, California, U.S.A.
    • Year and Date
      20070414-18

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Published: 2010-06-10   Modified: 2016-04-21  

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