Development of genetic diagnosis and drugs for lung cancer, based on protein phosphatase targeting

2009 Fiscal Year Final Research Report

• Project/Area Number: 19390370
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Thoracic surgery
• Research Institution: Miyagi Cancer Center Research Institute
• Principal Investigator: SATO Masami Miyagi Cancer Center Research Institute, 薬物療法学部, 特任研究員 (30250830)
• Co-Investigator(Kenkyū-buntansha): SHIMA Hiroshi 宮城県立がんセンター研究所, 薬物療法学部, 部長 (10196462) ; TANUMA Nobuhiro 宮城県立がんセンター研究所, 薬物療法学部, 研究員 (40333645) ; NOMURA Miyuki 宮城県立がんセンター研究所, 薬物療法学部, 技師 (40390893) ; SASAKI Nozomi 宮城県立がんセンター研究所, 薬物療法学部, 臨時職員 (50467429)
• Project Period (FY): 2007 – 2009
• Keywords: 呼吸器外科学 / プロテインホスファターゼ / スプライシング / 細胞内トランスポート / KIF3モーター / MAPK経路 / 遺伝子発現異常 / 遺伝子変異

Research Abstract

(1) Regulation of mRNA splicing, intracellular transport using KID3 motor, and ERK activation by protein phosphatases has been revealed.
(2) Expression of protein phosphatase genes in lung tumor tissues has been analyzed.

Research Products

• [Journal Article] MKP-7, a JNK phosphatase, blocks ERK-dependent gene activation by anchoring phosphorylated ERK in the cytoplasm. (2010)
  • Author(s): Masuda K, Katagiri C, Nomura M, Sato M, Kakumoto K, Akagi T, Kikuchi K, Tanuma N, Shima H.
  • Journal Title: Biochem Biophys Res Commun 393 Pages: 201-206
• [Journal Article] Protein phosphatase Dusp26 associates with KIF3 motor and promotes N-cadherin-mediaded cell-cel adhesion. (2009)
  • Author(s): Tanuma N, Nomura M, Ikdea M, Kusugai I, Tsubaki Y, Takagaki K, Kawamura T, Yamashita Y, Sato I, Sato M, Katakura R, Kikuchi K, Shima H
  • Journal Title: Oncogene 28 Pages: 752-76
• [Journal Article] Four year experience of the survey on quality control of lung cancer screening system in Japan. (2009)
  • Author(s): Sagawa M, Endo C, Sato M, Saito Y, Sobue T, Usuda K, Aikawa H, Fujimura S, Sakuma T
  • Journal Title: Lung Cancer 63 Pages: 291-294
• [Journal Article] Immunocytochemical evaluation of large cell neuroendocrine carcinoma of the lung (2009)
  • Author(s): Endo C, Honda M, Sakurada A, Sato M, Saito Y, Kondo T
  • Journal Title: Acta Cytol 53 Pages: 36-40
• [Journal Article] siRNA targeting against EGFR, a promising candidate for a novel therapeutic application to lung adenocarcinoma Pathobiology (2008)
  • Author(s): Yamanaka S, Gu Z, Sato M, Fujisaki R, Inomata K, Sakurada A, Inoue A, Nukiwa T, Kondo T, Horii A
  • Journal Title: 75 Pages: 2-8
• [Journal Article] The methylation status of FBXW7 beta-form correlates with histological subtype in human thymoma, Biochem Biophys Res Commun (2008)
  • Author(s): Gu Z, Mitsui H, Inomata K, Honda M, Endo C, Sakurada A, Sato M, Okada Y, Kondo T, Horii A
  • Journal Title: 377 Pages: 685-688
• [Journal Article] Nuclear inhibitor of protein phosphatase-1 (NIPP1) directs protein phosphatase-1(PP1) to dephosphorylate the U2 small nuclesr ribonucleoprotein particle(snRNP)component (2008)
  • Author(s): Tanuma N, Kim SE, Buellens M, Tsubaki Y, Mitsuhashi S, Nomura M, Kawamura T, Isono K, Koseki H, Sato M, Bollen M, Kikuchi K, Shima H
  • Journal Title: spliceosome-associated protein 155 (Sap155). J Biol Chem 52 Pages: 35805-35814
• [Journal Article] siRNA targeting against EGFR (2008)
  • Author(s): Yamanaka S, Gu Z, Sato M, Fujisaki R, Inomata K, Sakurada A, Inoue A, Nukiwa T, Kondo T, Horii A
  • Journal Title: a promising candidate for a novel therapeutic application to lung adenocarcinoma. Pathobiology 75(1) Pages: 2-8
• [Presentation] Dusp26 Associates with KIF3 Motor and Promotes Cadherin-Mediated Cell-Cell Adhesion EUROPHOSPHATASE 2009 (2009)
  • Author(s): Miyuki Nomura, Nobuhiro Tanuma, Isao Kasugai, Masami Sato, Hiroshi Shima
  • Organizer: Protein phosphatases in development and disease, Egmond aan Zee
  • Place of Presentation: The Netherlands
  • Year and Date: 2009-07-16
• [Presentation] シンポジウム2、気管支鏡による肺門部画像診断の最先端、Optical biopsyの時代へ-OCTによる上皮層から軟骨層までの画像観察- (2009)
  • Author(s): 佐藤雅美、高橋里美、前田寿美子、阿部二郎、前門戸任、松原信行
  • Organizer: 第32回日本呼吸器内視鏡学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2009-05-29
• [Presentation] Trends in incidence of lung cancer by histological type in Miyagi (2008)
  • Author(s): Yoshikazu Nishino, Masami Sato, Yuko Minami, Ichiro Tsuji
  • Organizer: Japan IACR meeting
  • Place of Presentation: Sydney
  • Year and Date: 20081100
• [Presentation] 肺切除術後における血清トロンボモジュリン値の変化 (2008)
  • Author(s): 前田寿美子、野津田泰嗣、高橋里美、小池加保児、佐藤雅美
  • Organizer: 第25回日本呼吸器外科学会総会
  • Place of Presentation: 宇都宮
  • Year and Date: 2008-05-29
• [Presentation] マレイン酸イルソグラジンを用いた原発性肺癌完全切除術後治療の無作為化比較試験 (2007)
  • Author(s): 高橋里美、佐藤雅美、一ノ瀬高志、佐川元保、遠藤千顕、佐藤徹、鈴木弘行、千田雅行、佐久間勉、佐藤信之、谷田達男、中村好宏、羽隅透、菅野隆三、近藤丘
  • Organizer: 第48回日本肺癌学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2007-11-09
• [Book] 呼吸器症候群(第2版)III-その他の呼吸器疾患も含めて-VIII腫瘍性疾患、E. その他の腫瘍性病変、重複癌
  • Author(s): 佐藤雅美, 他
  • Total Pages: 246-249
  • Publisher: 日本臨床社
• [Remarks]
  • URL: http://www.pref.miyagi.jp/mcc/