2009 Fiscal Year Final Research Report
Elucidation and control of cerebral neurophysiological function with focal brain-cooling for the purpose of clinical application.
| Project/Area Number |
19390380
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Yamaguchi University |
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Principal Investigator |
SUZUKI Michiyasu Yamaguchi University, 大学院・医学系研究科, 教授 (80196873)
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| Co-Investigator(Kenkyū-buntansha) |
FUJII Masami 山口大学, 医学部附属病院, 准教授 (90181320)
SAITO Takashi 山口大学, 大学院・医学系研究科, 教授 (10162207)
NOMURA Sadahiro 山口大学, 医学部附属病院, 講師 (20343296)
ISHIZUKA Satoshi 九州工業大学, 大学院・生命体工学研究科, 准教授 (40124804)
KAJIWARA Koji 山口大学, 大学院・医学系研究科, 准教授 (90253161)
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| Research Collaborator |
MARUTA Yuichi 山口大学, 大学院・医学系研究科, 助教 (30543970)
FUJIOKA Hiroshi 山口大学, 医学部附属病院, 研修医
OKU Takayuki 山口大学, 大学院・医学系研究科・博士課程
UCHIYAMA Jyouji 山口大学, 大学院・医学系研究科・博士課程
TANAKA Nobuhiro 山口大学, 大学院・医学系研究科・博士課程
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| Project Period (FY) |
2007 – 2009
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| Keywords | 脳冷却 / 生体システム / ペルチエ素子 / 脳機能情報制御 / てんかん / 難治性疼痛ニューロモデュレーション |
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| Research Abstract |
The aim of our study is to establish a focal brain cooling as a new treatment of epilepsy, intractable pain or severe neurotrauma. In the field of epilepsy, we demonstrated that focal cooling of the brain to a cortical surface temperature of 15 to 20℃ terminated epileptiform discharges without inducing irreversible neurophysiological dysfunctions or neuronal damage in brain tissue. We also confirmed the significant suppression of nociceptive pain due to the cooling of sensorimotor cortex, with a minimal influence on neurological functions in rats. Our studies suggest the focal cooling of the brain has a neuroprotective effect and has a therapeutic potential for patients who are suffering from severe brain disorders. Because of recent advances in the precision machinery industry, the application of an implantable local cooling system may be expected to become a reality in the near future. Finally, we advocate "thermal neuromodulation" as a new treatment paradigm.
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[Presentation] Efficacy of the Motor Evoked Potentials Monitoring During cerebral aneurysn surgery2009
Author(s)
asami Fujii, Yuichi Maruta, Hirochika Imoto, Hiroshi Yoneda, Hideyuki Ishihara, , Sadahiro Nomura, Koji Kajiwara, Shoichi Kato, Michiyasu Suzuki
Organizer
9th International Conference on Cerebrovascular Surgery
Place of Presentation
Nagoya, Japan
Year and Date
20091111-20091113
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[Presentation] An Implantable, Automated Focal Cerebral-Cooling System Suppresses Epileptic Seizures in Free-Moving, Spontaneously Epileptic Rats.2008
Author(s)
Hiroshi Fujioka, Masami Fujii, Hiroyasu Koizumi, Joji Uchiyama, Yuji Kurata, Takashi Saito, Hirochika Imoto, Sadahiro Nomura, Michiyasu Suzuki
Organizer
Congress of Neurological Surgeons, 2008 Annual Meeting
Place of Presentation
Orlando USA
Year and Date
20080920-20080925
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