2009 Fiscal Year Final Research Report
The basic study of the effect of biocompatible phospholipid polymer on the osteoarthritis progression
| Project/Area Number |
19390388
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | The University of Tokyo |
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Principal Investigator |
MORO Toru The University of Tokyo, 医学部附属病院, 特任准教授 (20302698)
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| Co-Investigator(Kenkyū-buntansha) |
TAKATORI Yoshio 東京大学, 医学部附属病院, 特任教授 (40179461)
ISHIHARA Kazuhiko 東京大学, 大学院・工学系研究科, 教授 (90193341)
KAWAGUCHI Hiroshi 東京大学, 医学部附属病院, 准教授 (40282660)
SEICHI Atsushi 東京大学, 医学部附属病院, 講師 (70236066)
KARITA Tatsuro 東京大学, 医学部附属病院, 講師 (80359611)
KONNO Tomohiro 東京大学, 大学院・工学系研究科, 特任准教授 (80371706)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 医療・福祉 / 生体材料 / ナノバイオ / バイオテクノロジー / トランスレーショナルリサーチ |
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| Research Abstract |
To evaluate the effect of biocompatible phospholipid polymer on the osteoarthritis progression, we used the ball-on-flat machine, which mimicked a natural joint, and the experimental osteoarthritis model. The friction tests using a ball-on-flat machine revealed that phospholipid polymer extremely improved the friction coefficient as compared to water and hyaluronic acid treatment. In addition, phospholipid polymer prevented the osteoarthritis progression in the experimental osteoarthritis model. From these results of the study, we believe that this new technology will prevent the osteoarthritis progression.
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[Journal Article] C/EBPβ promotes transition from proliferation to hypertrophic differentiation of chondrocytes through transactivation of p57^<Kip2>2009
Author(s)
Hirata M, Kugimiya F, Fukai A, Ohba S, Kawamura N, Ogasawara T, Kawasaki Y, Saito T, Yano F, Ikeda T, Nakamura K, Chung UI, Kawaguchi H
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Journal Title
Peer Reviewed
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[Presentation] Akt1 in chondrocytes controls cartilage calcification during skeletal growth and osteophyte formation in osteoarthritis2010
Author(s)
Fukai A, Kawamura N, Saito T, Oshima Y, Ikeda T, Yano F, Ogata N, Nakamura K, Chung UI, Kawaguchi H
Organizer
56th Annual Meeting of the Orthopaedic Research Society (ORS)
Place of Presentation
New Orleans, USA
Year and Date
20100306-20100309
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[Presentation] Distinct transcriptional control of chondrocyte hypertrophy and cartilage degeneration by C/EBP-beta and Runx2 during endochondral ossification2009
Author(s)
Hirata M, Kugimiya F, Fukai A, Saito T, Kan A, Higashikawa A, Yano F, Ikeda T, Nakamura K, Chung UI, Kawaguchi H
Organizer
2009 World Congress on Osteoarthritis (OARSI)
Place of Presentation
Monteral, Canada
Year and Date
20090910-20090913
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[Presentation] Transcriptional Regulation of Type X Collagen Expression and Hypertrophic Differentiation of Chondrocytes by Runx2 during Osteoarthritis Progression2009
Author(s)
Higashikawa A, Saito T, Kamekura S, Ikeda T, Kan A, Moro T, Ohba S, Ogata N, Nakamura K, Chung UI, Kawaguchi H
Organizer
The 55th Annual Meeting of the Orthopaedic Research Society (ORS)
Place of Presentation
Las Vegas, USA
Year and Date
20090222-20090225
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