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2009 Fiscal Year Final Research Report

Development of rapid and simultaneous diagnosis and therapy for musculoskeletal sarcomas using acridine orange excited by high-power flash light

Research Project

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Project/Area Number 19390390
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthopaedic surgery
Research InstitutionMie University

Principal Investigator

KUSUZAKI Katsuyuki  Mie University, 大学院・医学研究科, 教授 (30177993)

Co-Investigator(Kenkyū-buntansha) UCHIDA Atsumasa  三重大学, 大学院・医学研究科, 教授 (40176681)
MATSUMINE Akihiko  三重大学, 医学部附属病院, 講師 (00335118)
KUMAMOTO Tadashi  三重大学, 大学院・医学研究科, 助教 (50362348)
WAKABAYASHI Hiroki  三重大学, 大学院・医学研究科, 助教 (50362687)
SATONAKA Haruhiko  三重大学, 大学院・医学研究科, 医員 (60515485)
NAKAMURA Tomoki  三重大学, 医学部附属病院, 医員 (50467362)
MATSUBARA Takao  三重大学, 医学部附属病院, 医員 (30422827)
Project Period (FY) 2007 – 2009
Keywordsアクリジンオレンジ / 光線力学的診断 / 光線力学的治療法 / 骨軟部腫瘍 / ストロボ光
Research Abstract

To develop photodynamic diagnosis and photodynamic therapy using acridine orange excited by high-power flash light provided from xenon lamp in musculoskeletal sarcomas, we performed this study using mouse osteosarcoma model. Results showed that it was possible to brilliantly detect tumor localization through skin by PDD and to strongly inhibit tumor growth by PDT after intravenous AO injection followed by flash light illumination.

  • Research Products

    (25 results)

All 2010 2009 2008 2007 Other

All Journal Article (14 results) Presentation (11 results)

  • [Journal Article] Photodynamic therapy with acridine orangein musculoskeletal sarcomas.2010

    • Author(s)
      Matsubara T, Kusuzaki K, Matsumine A, Murata H, Marunaka Y, Hosogi S, Uchida A, Sudo A
    • Journal Title

      J Bone Joint Surg (Br) (in press)

  • [Journal Article] Clinical outcomes of minimally invasive surgery using acridine orange for musculoskeletal sarcomas around the forearm, compared with conventional limb salvage surgery after wide resection.2010

    • Author(s)
      Matsubara T, Kusuzaki K, Matsumine A, Murata H, Nakamura T, Uchida A, Sudo A
    • Journal Title

      J Surg Oncol (in press)

  • [Journal Article] In vivo anti-tumor activity of photodynamic therapy with intravenous administration of acridine orange, followed by illumination with high-power flash wave light in a mouse osteosarcoma model.2010

    • Author(s)
      Satonaka H, Kusuzaki K, Murata H, Matsubara T, Shintani K, Nakamura T, Matsumine A, Iino T, Uchida A
    • Journal Title

      Oncology Letters 1

      Pages: 69-72

  • [Journal Article] Three-dimensional alginate spheroid culture system of murine osteosarcoma.2009

    • Author(s)
      Akeda K, Nishimura A, Satonaka H, Shintani K, Kusuzaki K, Matsumine A, Kasai Y, Masuda K, Uchida A
    • Journal Title

      Oncol Rep 22

      Pages: 997-1003

  • [Journal Article] Decorin suppresses bone metastasis in a breast cancer cell line.2009

    • Author(s)
      Araki K, Wakabayashi H, Shintani K, Morikawa J, Matsumine A, Kusuzaki K, Sudo A, Uchida A
    • Journal Title

      Oncology (Bazel) 77

      Pages: 92-99

  • [Journal Article] A new therapeutic modality involving acridine orange excitation by photon energy used during reduction surgery for rhabodomyosarcomas.2009

    • Author(s)
      Matsubara T, Kusuzaki K, Matsumine A, Murata H, Satonaka H, Shinntani K, Nakamura T, Hosoi H, Iehara T, Sugimoto T, Uchida A
    • Journal Title

      Oncol Rep 21

      Pages: 89-94

  • [Journal Article] Usefulness of limb salvage surgery for bone and soft tissue sarcomas of the distal lower leg.2008

    • Author(s)
      Niimi R, Matsumine A, Kusuzaki K, Araki N, Aoki Y, Ueda T, Kudahara I, Myoui A, Ieguchi M, Hashimoto N, Yoshikawa H, Uchida A
    • Journal Title

      J Cancer Res Clin Oncol 134

      Pages: 1087-1095

  • [Journal Article] Decorin suppresses lung metastasis of murine osteosarcoma.2008

    • Author(s)
      Shintani K, Matsumine A, Kusuzaki K, Morikawa J, Matsubara T, Wakabayashi T, Araki K, Satonaka H, Wakabayashi H, Iino T, Uchida A
    • Journal Title

      Oncol Rep 19

      Pages: 1533-1539

  • [Journal Article] A new limb salvage surgery in cases of high-grade soft tissue sarcoma using photodynamic surgery, followed by photo-and radiodynamic therapy with acridine orange.2008

    • Author(s)
      Nakamura T, Kusuzaki K, Matsubara T, Matsumine A, Murata H, Uchida A
    • Journal Title

      J Surg Oncol 97

      Pages: 523-528

  • [Journal Article] Novel hyperthermia for metastatic bone tumors magnetic materials by generating electromagnetic field.2007

    • Author(s)
      Matsumine A, Kusuzaki K, Matsubara T, Shintani K, Satonaka H, Wakabayashi T, Miyazaki S, Morita K, Takegami K, Uchida A
    • Journal Title

      Clin Exp Metastasis 24

      Pages: 191-200

  • [Journal Article] Flash wave light strongly enhanced cytocidal effect of photodynamic therapy with acridine orange on mouse osteosarcoma cell line.2007

    • Author(s)
      Satonaka H, Kusuzaki K, Murata H, Matsubara T, Shintani K, Wakabayashi T, Matsumine A, Kimura M, Kawashima N, Uchida A
    • Journal Title

      Anticancer Res 27

      Pages: 3339-3344

  • [Journal Article] Acridine orange could be an innovative anticancer agent under photon energy.2007

    • Author(s)
      Kusuzaki K, Murata H, Matsubara T, Satonaka H, Wakabayashi T, Matsumine A, Uchida A
    • Journal Title

      In vivo 21

      Pages: 205-214

  • [Journal Article] Extracorporeal photodynamic image detection of mouse osteosarcoma in soft tissues utilizing fluorovisualization effect of acridine orange.2007

    • Author(s)
      Satonaka H, Kusuzaki K, Shintani K, Matsumine A, Matsubara T, Wakabayashi T, Uchida A
    • Journal Title

      Oncology (Bazel) 70

      Pages: 465-473

  • [Journal Article] Methylene blue in place of acridine orange as a photosensitizer in photodynamic therapy of osteosarcoma.

    • Author(s)
      Matsubara T, Kusuzaki K, Matsumine A, Satonaka H, Shinntani K, Nakamura T, Uchida A
    • Journal Title

      In vivo 22

      Pages: 297-304

  • [Presentation] In vivo antitumor activity of photodynamic therapy with intravenous administration of acridine orange followed by illumination with high-power flash wave light in a mouse osteosarcoma model.2010

    • Author(s)
      Satonaka H, Kusuzaki K, Matsubara T, Shintani K, Nakamura T, Matsumine A, Iino T, Uchida A
    • Organizer
      56th Annual Meeting of Orthopaedic Research Society. 2010 March
    • Place of Presentation
      New Oreans, USA
    • Year and Date
      20100311-20100314
  • [Presentation] Clinical Outcomes with the KYOCERA Physio Hinge Total Knee System Type III after the Resection of a bone and soft tissue tumor of the Distal Part of the Femur: from the Japanese Musculoskeletal Oncology Group 8th.2010

    • Author(s)
      Matsumine A, Kusuzaki K, Sugita T, Yazawa Y, Isu K, Kawai A, Abe S, Yakushiji T, Ueda T, Uchida A
    • Organizer
      Asia Pacific Musculoskeletal Tumor Society Meeting
    • Place of Presentation
      Sebu Philippin
    • Year and Date
      20100000
  • [Presentation] Expression of SAP97 as a biomarker of outcome in malignant fibrous histiocytomas.2009

    • Author(s)
      Niimi R, Matsumine A, 1Iino T, Shintani K, Nakazora S, Nakamura T, Kusuzaki K, Uchida A
    • Organizer
      55th Annual Meeting of the Orthopaedic Research Society
    • Place of Presentation
      Las Vegas USA
    • Year and Date
      20090308-20090310
  • [Presentation] Three-dimensional alginate spheroid culture system of murine osteosarcoma.2009

    • Author(s)
      Nishimura A, Akeda K, Kusuzaki K, Matsumine A, Masuda K, Morimoto R, Okamura N, Kasai Y, 1Iino T, Uchida A
    • Organizer
      55th Annual Meeting of the Orthopaedic Research Society
    • Place of Presentation
      Las Vegas USA
    • Year and Date
      20090308-20090310
  • [Presentation] Acridine orange found in Ehrlich's era could be a "Magic Bullet" against cancer under photon energy.2008

    • Author(s)
      Kusuzaki K, Murata H, Matsubara T, Satonaka H, Nakamura T, Matsumine A, Uchida A
    • Organizer
      The 2nd World Confererence on Magic Bullets (Ehrlich II)
    • Place of Presentation
      Neurmberg, Germany
    • Year and Date
      20081003-20081005
  • [Presentation] Novel hyperthermia for metastatic bone tumors with magnetic materials.2008

    • Author(s)
      Matsumine A, Kusuzaki K, Matsubara T, Morita K, Takegami K, Uchida
    • Organizer
      7th Asia Pacific Musculoskeletal Tumor Society Meeting
    • Place of Presentation
      Beijin, China
    • Year and Date
      20080926-20080928
  • [Presentation] new limb salvage surgery in cases of high-grade soft tissue sarcoma using photodynamic surgery, followed by photo- and radio dynamic therapy with acridine orange.2008

    • Author(s)
      Nakamura T, Matsumine A, Kusuzaki K, Matsubara T, Niimi R, Nakazora Murata H, S, Uchida A
    • Organizer
      7th Asia Pacific Musculoskeletal Tumor Society Meeting
    • Place of Presentation
      Beijin, China
    • Year and Date
      20080926-20080928
  • [Presentation] In vivo antitumor effect of photodynamic therapy with acridine orange using flash wave light on osteosarcoma.2008

    • Author(s)
      Satonaka H, Kusuzaki K, Matsubara T, Shintani K, Wakabayashi T, Nakamura T, Matsumine A, Uchida A
    • Organizer
      7th Asia Pacific Musculoskeletal Tumor Society Meeting
    • Place of Presentation
      Beijin, China
    • Year and Date
      20080926-20080928
  • [Presentation] Extracorporeal photodynamic image detection of mouse osteosarcoma in soft tissues utilizing fluorovisualization effect of acridine orange.2007

    • Author(s)
      Satonaka H, Kusuzaki K, Matsubara T, Shintani K, Wakabayashi T, Matsumine A, Uchida A
    • Organizer
      The 14th International Symposium on Limb Salvage
    • Place of Presentation
      Hamburg, Germany
    • Year and Date
      20070911-20070914
  • [Presentation] Novel hyperthermia for metastatic bone tumors with magnetic materials by generating an alternating electromagnetic field.2007

    • Author(s)
      Matsumine A, Kusuzaki K, Matsubara T, Morita K, Takegami K, Uchida
    • Organizer
      The 14th International Symposium on Limb Salvage
    • Place of Presentation
      Hamburg, Germany
    • Year and Date
      20070911-20070914
  • [Presentation] Acridine orange could be an innovative anticancer agent under photon energy.2007

    • Author(s)
      Kusuzaki K, Matsubara T, Satonaka H, Wakabayashi T, Matsumine A, Uchida A
    • Organizer
      The 14th International Symposium on Limb Salvage
    • Place of Presentation
      Hamburg, Germany
    • Year and Date
      20070911-20070914

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Published: 2011-06-18   Modified: 2012-08-31  

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