2010 Fiscal Year Final Research Report
Analysis of correlation of angiogeneis and osteoclastogenesis/osteoclastic bone resorption in tumore-induced destruction of bone
| Project/Area Number |
19390397
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Kyushu University |
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Principal Investigator |
IWAMOTO Yukihide Kyushu University, 大学院・医学研究院, 教授 (00213322)
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| Co-Investigator(Kenkyū-buntansha) |
TSUNEYOSHI Masazumi 九州大学, 大学院・医学研究院, 名誉教授 (20091259)
ODA Yoshinao 九州大学, 大学院・医学研究院, 教授 (70291515)
FUKUSHI Junichi 九州大学, 大学病院, 助教 (40444806)
MATSUMOTO Yoshihiro 九州大学, 大学病院, 助教 (10346794)
SAKAMOTO Akio 九州大学, 大学院・医学研究院, 助教 (40335964)
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| Project Period (FY) |
2007 – 2010
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| Keywords | 腫瘍性骨破壊 / 破骨細胞 / 血管新生 / Vascular endothelial growth factor (VEGF) basic Fibroblast growth factor (bFGF) / 腫瘍随伴マクロファージ |
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| Research Abstract |
The molecular mechanism of tumor-induced bone destruction was investigated in this study. In tumor-induced bone destruction, tumora-associated macropahges (TAM) play major roles as a cell factor. As soluble factors, vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) are found to be critical in the tumor-induced bone destruction. Together, TAM, VEGF, and bFGF would be promising molecular targets for treating the tumor-induced bone destruction.
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