Identification and characterize anti-granulocyte-macrophage colony-stimulating factor autoantibody.

2009 Fiscal Year Self-evaluation Report

• Project/Area Number: 19390403
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: The University of Tokyo
• Principal Investigator: YAMADA Yoshitsugu The University of Tokyo, 医学部附属病院, 教授 (30166748)
• Project Period (FY): 2007 – 2010
• Keywords: 周術期管理学 / サイトカイン

Research Abstract

(1)健常者血清中に存在している抗GM-CSF自己抗体の存在を明らかにする
(2)抗GM-CSF自己抗体の生体における生理学的役割を明らかにする
(3)抗GM-CSF自己抗体が全身炎症状態でどのような挙動を示すか、またそれが病勢とどのように関わるかを明らかにする

Research Products

• [Journal Article] Response : Granulocyte/macrophage colony-stimulating factor autoantibodies and myeloid cell immune functions in healthy persons (2010)
  • Author(s): Uchida K, Carey B, Suzuki T, Nakata K, Trapnell B.
  • Journal Title: Blood 115(2) Pages: 431-3
• [Journal Article] Human GM-CSF autoantibodies and reproduction of pulmonary alveolar proteinosis (2009)
  • Author(s): Sakagami T, Uchida K, Suzuki T, Carey BC, Wood RE, Wert SE, Whitsett JA, Trapnell BC, Luisetti M.
  • Journal Title: N Engl J Med. 361(27) Pages: 2679-81
• [Journal Article] Pulmonary alveolar proteinosis, a primary immunodeficiency of impaired GM-CSF stimulation of macrophages (2009)
  • Author(s): Trapnell BC, Carey BC, Uchida K, Suzuki T.
  • Journal Title: Curr Opin Immunol. 21(5) Pages: 514-21
• [Journal Article] Granulocyte-macrophage colony-stimulating factor autoantibodies in murine ileitis and progressive ileal Crohn's disease (2009)
  • Author(s): Han X, Uchida K, Jurickova I, Koch D, Willson T, Samson C, Bonkowski E, Trauernicht A, Kim MO, Tomer G, Dubinsky M, Plevy S, Kugathsan S, Trapnell BC, Denson LA.
  • Journal Title: Gastroenterology 136(4) Pages: 1261-71
• [Journal Article] Granulocyte/Macrophage Colony-Stimulating Factor Autoantibodies and Myeloid Cell Immune Funcitons in Healthy Subjects (2009)
  • Author(s): Uchida K, Nakata K, Suzuki T, Luisetti M, Watanabe M, Koch DE, Stevens CA, Beck DC, Denson LA, Carey BC, Keicho N, Krischer JP, Yamada Y, Trapnell BC.
  • Journal Title: Blood 113(11) Pages: 2547-56
• [Presentation] 食道癌手術患者の侵襲に応じた好中球機能低下は術後早期回復に影響する (2009)
  • Author(s): 内田寛治, 室屋充明, 張京浩, 森和彦, 山田和彦, 瀬戸泰之, 伊藤伸子, 山田芳嗣
  • Organizer: 日本麻酔科学会第56回学術集会
  • Place of Presentation: 神戸市
  • Year and Date: 2009-08-17
• [Presentation] Reduced Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) Bioactivity with Surgical Stress Associated with Early Postoperative Complications (2009)
  • Author(s): Uchida K, Muroya M, Trapnell BC, Yamada K, Mori K, Seto Y, Yamada Y.
  • Organizer: American Thoracic Society International Conference
  • Place of Presentation: San Diego, USA
  • Year and Date: 2009-05-19
• [Presentation] Serologic Diagnosis of Pulmonary Alveolar Proteinosis (PAP) (2009)
  • Author(s): Uchida K, Nakata K, Koch DE, Carey BC, Suzuki T, Stevens CA, Yamada Y, Trapnell BC.
  • Organizer: American Thoracic Society International Conference
  • Place of Presentation: San Diego, USA
  • Year and Date: 2009-05-18
• [Presentation] ワークショップ3「基礎 : 炎症細胞の分離と機能的解析」「好中球」 (2008)
  • Author(s): 内田寛治
  • Organizer: 日本アレルギー学会第58回秋季学術集会
  • Place of Presentation: 東京
  • Year and Date: 2008-11-27
• [Presentation] フローサイトメトリー法による簡易好中球活性化指標測定法の開発 (2008)
  • Author(s): 内田寛治, Trapnell BC, 張京浩, 山田芳嗣
  • Organizer: 日本麻酔科学会学術集会
  • Place of Presentation: 横浜市
  • Year and Date: 2008-06-12
• [Presentation] A Stadardized, Serum-Based Approach For Diagnosing PAP (2008)
  • Author(s): Uchida K.
  • Organizer: American Thoracic Society International Conference
  • Place of Presentation: Toronto, Canada
  • Year and Date: 2008-05-21
• [Book] European Respiratory Monograph (Issue 46)(edited by RON DU BOIS AND LUCA RICHELDI, Pulmonary alveolar proteinosis in Interstitial Lung Diseases) (2009)
  • Author(s): Trapnell BC, Uchida K
  • Total Pages: 208-224