2009 Fiscal Year Final Research Report
Conquest of myocardial ischemia reperfusion injury-Control of RISK pathway and antioxidant mechanism-
| Project/Area Number |
19390406
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Nagasaki University |
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Principal Investigator |
SUMIKAWA Koji Nagasaki University, 大学院・医歯薬学総合研究科, 教授 (60028660)
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| Co-Investigator(Kenkyū-buntansha) |
CHO Sungsam 長崎大学, 病院, 講師 (90325655)
MIYOSHI Hiroshi 長崎大学, 病院, 助教 (90332858)
YOSHITOMI Osamu 長崎大学, 病院, 助教 (30380926)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 心筋虚血再灌流障害 / 心筋スタニング / 薬理学的プレコンディショニング / 薬理学的ポストコンディショニング / RISK pathway / 抗酸化作用 / アポトーシス |
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| Research Abstract |
Myocardial protection against the ischemia reperfusion injury is one of the clinically important problems. We examined the molecular mechanism of pharmacological preconditioning and postconditioning effects of inhalation anesthetic and circulation agonist to use for the perioperative period. As a result, we made clear that reperfusion injury salvage kinase (RISK) pathway was involved in myocardial protective effects. Also, we made clear that an endogenic antioxidant mechanism was involved in myocardial apoptosis control.
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Research Products
(37 results)
