2010 Fiscal Year Final Research Report
Mechanisms of endogenous cannabinoid receptor activation-induced analgesia and its application to intractable cancer pain
| Project/Area Number |
19390407
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
KAWAMATA Tomoyuki Sapporo Medical University, 医学部, 准教授 (80336388)
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| Co-Investigator(Kenkyū-buntansha) |
WATANABE Masahiko 北海道大学, 医学研究科, 教授 (70210945)
NARIMATSU Eichi 札幌医科大学, 医学部, 准教授 (70295343)
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| Project Period (FY) |
2007 – 2010
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| Keywords | がん疼痛 / 大麻 / 鎮痛 |
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| Research Abstract |
This study was planned to clarify the mechanism of CB1 activation-induced analgesia the analgesic effects of CB1 on bone cancer pain. Immunohistochemical experiments showed that, although mu opioid receptor 1 expression was reduced in the superficial dorsal horn, CB1 expression was preserved. In addition, CB1 was mainly expressed in the axon terminals of spinal excitatory interneurons. Spinal CB1 activation reduced bone cancer-related pain behaviors, including behaviors related to spontaneous pain and movement-evoked pain. Spinal CB1 activation reduced bone cancer-related pain behavior. Presynaptic inhibition may contribute to the analgesic effects of spinal CB1 activation. These findings may lead to novel strategies for the treatment of bone cancer pain.
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