2010 Fiscal Year Final Research Report
Analysis of cerebral microcirculatory regulation in relation to anesthetics and gene therapy using the live-cell imaging
Project/Area Number |
19390409
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Anesthesiology/Resuscitation studies
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Research Institution | Wakayama Medical University |
Principal Investigator |
KINOSHITA Hiroyuki Wakayama Medical University, 医学部, 准教授 (70291490)
|
Co-Investigator(Kenkyū-buntansha) |
MATSUDA Naoyuki 名古屋大学, 大学院・医学研究科, 教授 (50332466)
NAKAHATA Katsutoshi 和歌山県立医科大学, 医学部, 助教 (70332971)
HATANO Yoshio 和歌山県立医科大学, 医学部, 教授 (70115913)
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Project Period (FY) |
2007 – 2010
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Keywords | 麻酔学 |
Research Abstract |
We employed the computer-assisted microscopy to evaluate microvascular function in the rat brain slices. Electrical stimulation induced constriction of the cerebral parenchymal arteriole, whereas an inhibitor of 20-HETE abolished this response. NMDA, which is one of excitatory amino acids, produced dilation of these arterioles, corresponding with intracellular production of superoxide in addition to nitric oxide in the smooth muscle cells. Propofol within clinically relevant concentrations reduced these vascular responses.
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Research Products
(17 results)