2009 Fiscal Year Final Research Report
Persistent biofilms in urinary tract infections -the development of novel methods for identifying antibiofilm agents-
| Project/Area Number |
19390415
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Okayama University |
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Principal Investigator |
UEHARA Shinya Okayama University, 岡山大学病院, 助教 (30379739)
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| Co-Investigator(Kenkyū-buntansha) |
KARIYAMA Reiko 岡山大学, 大学院・医歯薬学総合研究科, 助教 (40112148)
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| Co-Investigator(Renkei-kenkyūsha) |
WATANABE Toyohiko 岡山大学, 岡山大学病院, 講師 (30432644)
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| Research Collaborator |
KUMON Hiromi 岡山大学, 大学院・医歯薬学総合研究科, 教授 (30144760)
SUGA Hiroaki 東京大学, 先端科学技術研究センター, 教授 (00361668)
STEWART Philip s. モンタナ州立大学(米国), バイオフィルム工学研究所, 教授
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| Project Period (FY) |
2007 – 2009
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| Keywords | 難治性尿路感染症 / 日和見感染菌 / バイオフィルム / 抗バイオフィルム剤 / スクリーニング / クオラムセンシング / in vitro実験モデル系 / in vivo実験モデル系 |
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| Research Abstract |
In order to establish new strategies for prevention and therapy of persistent biofilms in urinary tract infections, we developed novel methods for identifying antibiofilm agents. In this study period, major technological advances on in vitro and in vivo models were made. The evaluated some potential agents yielded a compound which inhibited quorum sensing and biofilm formation in Pseudomonas aeruginosa. A combination of the newly detected compound and antimicrobial agents is suggested as a novel therapeutic approach.
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