2009 Fiscal Year Final Research Report
Molecular physiological investigations into the commonality and heterogeneity of interstitial cells in the urogenital system
| Project/Area Number |
19390418
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Nagoya City University |
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Principal Investigator |
HASHITANI Hikaru Nagoya City University, 大学院・医学研究科, 准教授 (10315905)
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| Co-Investigator(Kenkyū-buntansha) |
SUZUKI Hikaru 名古屋市立大学, 大学院・医学研究科, 教授 (80037548)
KUBOTA Yasue 名古屋市立大学, 大学院・医学研究科, 助教 (00381830)
KOHRI Kenjiro 名古屋市立大学, 大学院・医学研究科, 教授 (30122047)
SOJI Tsuyoshi 名古屋市立大学, 大学院・医学研究科, 教授 (50056925)
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| Project Period (FY) |
2007 – 2009
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| Keywords | Kit受容体 / ミトコンドリア / 平滑筋 / 泌尿生殖器系 / 活動電位 / 細胞内カルシウム / 自動運動 / 間質細胞 |
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| Research Abstract |
Interstitial cells (ICs) in the urinary tract developed spontaneous Ca^<2+> transients arising from the endoplasmic reticulum Ca^<2+> release in cooperation with the perinuclear mitochondrial Ca^<2+> handling. Spontaneous Ca^<2+> transients in ICs exhibited little temporal relationship with smooth muscle Ca^<2+> signals, and atypical smooth muscle cells play a pacemaker role in the renal pelvis. The number of Kit-positive ICs was increased in the obstructed bladders, while the mice which have a mutation on Kit receptor (W/W^v) or its ligand stem cell factor (Sl/Sl^d) had effects on neither the distribution of ICs nor the smooth muscle contractility.
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