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2009 Fiscal Year Final Research Report

New approach for diagnosis and treatment of head and neck cancer by proteomics analysis

Research Project

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Project/Area Number 19390432
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Otorhinolaryngology
Research InstitutionHokkaido University

Principal Investigator

FUKUDA Satoshi  Hokkaido University, 大学院・医学研究科, 教授 (20125347)

Co-Investigator(Kenkyū-buntansha) HOMMA Akihiro  北海道大学, 大学病院, 講師 (30312359)
HATAKEYAMA Shigetugu  北海道大学, 大学院・医学研究科, 教授 (70294973)
SHIRATO Hiroki  北海道大学, 大学院・医学研究科, 教授 (20187537)
Project Period (FY) 2007 – 2009
Keywords頭頸部癌 / プロテオーム / ユビキチン
Research Abstract

We analyzed the function of Ubiquitin in head and neck cancer. We considered TRIM32 and UBE2Q2 as a important factor to control the treatment of advanced head and neck Cancer.

  • Research Products

    (5 results)

All 2009 2008

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (2 results)

  • [Journal Article] Ubiquitin-Conjugating Enzyme UBE2Q2 Suppresses Cell Proliferation and Is Down-Regulated in Recurrent Head and Neck Cancer2009

    • Author(s)
      Maeda H, Miyajima N, Kano S, Tsukiyama T, Okumura F, Fukuda S, Hatakeyama S
    • Journal Title

      Mol Cancer Res 7

      Pages: 1553-1562

    • Peer Reviewed
  • [Journal Article] Tripartite motif protein 32 facilitates cell growth and migration via degradation of Abl-interactor 22008

    • Author(s)
      Kano S, Miyajima N, Fukuda S, Hatakeyama S
    • Journal Title

      Cancer Res 68

      Pages: 5572-5580

    • Peer Reviewed
  • [Journal Article] Increased mitochondrial DNA induces acquired docetaxel resistance in head and neck cancer cells2008

    • Author(s)
      Mizumachi T, Suzuki S, Naito A, Carcel-Trullols J, Evans TT, Spring PM, Oridate N, Furuta Y, Fukuda S
    • Journal Title

      Oncogene 27

      Pages: 831-838

    • Peer Reviewed
  • [Presentation] UBE 2 Q 2 suppresses cell proliferation and is down-regulated in recurrent head and neck cancer2009

    • Author(s)
      真栄田裕行, 加納里志, 畠山鎮次, 福田諭
    • Organizer
      第110回日本耳鼻咽喉科学会
    • Place of Presentation
      東京
    • Year and Date
      20090514-20090516
  • [Presentation] TRIM32 facilitates cell growth, migration and anti-apoptosis2008

    • Author(s)
      Kano S, Hatakeyama S, Fukuda S
    • Organizer
      The 12th Japan-Korea Joint Meeting of Otorhinolaryngology-Head and Neck Surgery
    • Place of Presentation
      Nara, Japan
    • Year and Date
      20080403-20080405

URL: 

Published: 2011-06-18   Modified: 2016-04-21  

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