2009 Fiscal Year Final Research Report
Analysis of relationship in immune barrier function between human nasal epithelial cell and dendritic cell.
| Project/Area Number |
19390436
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
HIMI Tetsuo Sapporo Medical University, 医学部, 教授 (90181114)
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| Co-Investigator(Kenkyū-buntansha) |
KOJIMA Takashi 札幌医科大学, 医学部, 准教授 (30260764)
GO Mitsuru 札幌医科大学, 医学部, 講師 (80448604)
ICHIMIYA Shingo 札幌医科大学, 医学部, 講師 (30305221)
TAKANO Ken-ichi 札幌医科大学, 医学部, 助教 (70404689)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 鼻粘膜 / 上皮細胞 / タイト結合 / 樹状細胞 / 抗原提示細胞 / サイトカイン / アレルギー性鼻炎 |
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| Research Abstract |
Analysis of a immune barrier function with primary culture system of human nasal mucosa epithelium is important to establish a methodology of inflammation control by trans-nasal administration. Tight junction is one of an important factor contributing to permeability of a material, and it is important to study a factor regulating this function. Furthermore, examination of immunocompetent cell about an antigen sampling such as dendritic cell contributes to establish the mechanism of immune therapy for allergic rhinitis or upper respiratory infection by trans-nasal administration.
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