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2008 Fiscal Year Final Research Report

Technology of multi-layered tissue engineering for the head and neck organs

Research Project

  • PDF
Project/Area Number 19390437
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Otorhinolaryngology
Research InstitutionFukushima Medical University

Principal Investigator

OMORI Koichi  Fukushima Medical University, 医学部, 教授 (10233272)

Co-Investigator(Kenkyū-buntansha) HAZAMA Akihiro  福島県立医科大学, 医学部, 教授 (60218394)
NAKAMURA Tatsuo  京都大学, 再生医学研究所, 准教授 (70227908)
WADA Ikuo  福島県立医科大学, 医学部, 教授 (40182969)
Co-Investigator(Renkei-kenkyūsha) HAZAMA Akihiro  福島県立医科大学, 医学部, 教授 (60218394)
NAKAMURA Tatsuo  京都大学, 再生医学研究所, 准教授 (70227908)
WADA Ikuo  福島県立医科大学, 医学部, 教授 (40182969)
Project Period (FY) 2007 – 2008
Keywords移植・再生医療 / 細胞・組織 / バイオテクノロジー
Research Abstract

本研究の目的は頭頸部臓器切除後の機能障害の回避とQuality of Lifeの向上をはかり、国民の健康に貢献することにある。頭頸部組織再生をはかるために、線維芽細胞を用いて早期に気管上皮を再生させることができた。歯肉由来線維芽細胞は上皮形成効果が高いこと、脂肪組織由来幹細胞は血管新生能があることを明らかにした。複数の細胞を導入して人工材料を作製し、これを移植し頭頸部の多層構造を同時に再生させる基盤技術を開発した。

  • Research Products

    (28 results)

All 2009 2008 2007 Other

All Journal Article (13 results) (of which Peer Reviewed: 9 results) Presentation (13 results) Book (1 results) Remarks (1 results)

  • [Journal Article] 耳鼻咽喉科臨床の進歩-喉頭・気管の再生医療-2009

    • Author(s)
      大森孝一, 中村達雄, 多田靖宏, 野本幸男, 鈴木輝久, 金丸眞一, 安里亮, 山下勝, 岡野渉
    • Journal Title

      日本耳鼻咽喉科学会会報 112(3)

      Pages: 104-109

  • [Journal Article] 移植細胞の動態観察のためのin vivo蛍光・発光標識法2009

    • Author(s)
      東恒仁, 野本幸男, 小林謙, 大森孝一, 和田郁夫
    • Journal Title

      Surger Frontier 16(1)

      Pages: 79-84

  • [Journal Article] Clinical application of in situ tissue engineering using a scaffolding technique for reconstruction of the larynx and trachea2008

    • Author(s)
      Omori K, Tada Y, Suzuki T, Nomoto Y, Matsuzuka T, Kobayashi K, Nakamura T, Kanemaru S, Yamashita M, Asato R
    • Journal Title

      Ann Otol Rhinol Laryngol 117(9)

      Pages: 673-678

    • Peer Reviewed
  • [Journal Article] In situ tissue engineering of the cricoid and trachea in a canine model2008

    • Author(s)
      Omori K, Nakamura T, Kanemaru S, Magrufov A, Yamashita M, Shimizu Y
    • Journal Title

      Ann Otol Rhinol Laryngol 117(8)

      Pages: 609-613

    • Peer Reviewed
  • [Journal Article] Tissue-engineered airway replacement2008

    • Author(s)
      Sato T, Nakamura T
    • Journal Title

      Lancet 372(9655)

      Pages: 2023-2030

    • Peer Reviewed
  • [Journal Article] Regeneration of tracheal epithelium utilizing a novel bi-potential collagen scaffold2008

    • Author(s)
      Tada Y, Takezawa Y, Suzuki T, Nomoto Y, Kobayashi K, Nakamura T, Omori K
    • Journal Title

      Ann Otol Rhinol Laryngol 117(5)

      Pages: 359-365

    • Peer Reviewed
  • [Journal Article] Replacement of the left main bronchus with a tissue-engineered prosthesis in a canine model2008

    • Author(s)
      Sato T, Tao H, Araki M, Ueda H, Omori K, Nakamura T
    • Journal Title

      Ann Thoracic Surgery 86(2)

      Pages: 422-428

    • Peer Reviewed
  • [Journal Article] Regeneration of the trachea using a bio-engineered scaffold with adipose-derived stem cells2008

    • Author(s)
      Suzuki T, Kobayashi K, Tada Y, Suzuki Y, Wada I, Nakamura T, Omori K
    • Journal Title

      Ann Otol Rhinol Laryngol 117(6)

      Pages: 453-463

    • Peer Reviewed
  • [Journal Article] Effect of fibroblasts on epithelial regeneration on the surface of a bioengineered trachea2008

    • Author(s)
      Nomoto Y, Kobayashi K, Tada Y, Wada I, Nakamura T, Omori K
    • Journal Title

      Ann Otol Rhinol Laryngol 117(1)

      Pages: 59-64

    • Peer Reviewed
  • [Journal Article] 気道再建と再生医療2008

    • Author(s)
      大森孝一, 中村達雄, 多田靖宏, 野本幸男, 鈴木輝久, 小林謙, 金丸眞一, 安里亮, 山下勝
    • Journal Title

      耳鼻と臨床 54(5)

      Pages: 271-279

  • [Journal Article] 細胞移植による声帯再生のための細胞培養液の検討2008

    • Author(s)
      金丸眞一, 梅田裕生, 末廣篤, 大野恒久, 木谷芳晴, 岸本曜, 田村芳寛, 平野滋, 大森孝一
    • Journal Title

      喉頭 20(1)

      Pages: 1-4

  • [Journal Article] Potential of heterotopic fibroblasts as autologous transplanted cells for tracheal epithelial regeneration2007

    • Author(s)
      Kobayashi K, Suzuki T, Nomoto Y, TadaY, Miyae M, Hazama A, Nakamura T, Omori K
    • Journal Title

      Tissue Engineering 13(9)

      Pages: 2175-2184

    • Peer Reviewed
  • [Journal Article] Bone regeneration of canine skull using bone marrow - derived stromal cells and β-tricalcium phosphate2007

    • Author(s)
      Umeda H, Kanemaru S, Yamashita M, Kishimoto M, Tamura Y, Nakamura T, Omori K, Hirano S, Ito J
    • Journal Title

      Laryngoscope 117(6)

      Pages: 997-1003

    • Peer Reviewed
  • [Presentation] Tissue Engineeringによるウサギ気管再生 : 線維芽細胞の有用性2009

    • Author(s)
      岡野渉, 野本幸男, 多田靖宏, 大森孝一
    • Organizer
      第8回日本再生医療医学会
    • Place of Presentation
      東京
    • Year and Date
      2009-03-06
  • [Presentation] Evaluation of bi-potential scaffold for regeneration of the trachea - in vitro and in vivo studies2008

    • Author(s)
      Tada Y, Takezawa T, Suzuki T, Kobayashi K, Nakamura T, Omori K
    • Organizer
      The 111th Annual Meeting of the Triological Society Orlando
    • Place of Presentation
      USA
    • Year and Date
      20080501-04
  • [Presentation] 〔指定演題〕組織工学的手法による気道狭窄に対する治療2008

    • Author(s)
      金丸眞一, 平野滋, 田村芳寛, 末廣篤, 梅田裕生, 大森孝一, 伊藤壽一
    • Organizer
      第60回日本気管食道科学会
    • Place of Presentation
      熊本
    • Year and Date
      2008-11-07
  • [Presentation] ウサギ線維芽細胞を含有した人工材料による気管の再生2008

    • Author(s)
      岡野渉, 野本幸男, 鈴木輝久, 多田靖宏, 中村達雄, 大森孝一
    • Organizer
      第60回日本気管食道科学会
    • Place of Presentation
      熊本
    • Year and Date
      2008-11-07
  • [Presentation] 〔Instruction Course〕Instructor, Tissue engineering for regenerative medicine2008

    • Author(s)
      Omori K
    • Organizer
      The 2008 Annual Meeting of American Academy of Otolaryngology-Head and Neck Surgery
    • Place of Presentation
      Chicago, USA,
    • Year and Date
      2008-09-22
  • [Presentation] ウサギ線維芽細胞を含有した人工材料による気管の再生2008

    • Author(s)
      岡野渉, 野本幸男, 鈴木輝久, 多田靖宏, 中村達雄, 大森孝一
    • Organizer
      第29回日本炎症・再生医学会
    • Place of Presentation
      東京
    • Year and Date
      2008-07-09
  • [Presentation] 〔シンポジウム〕気道領域の再生医療2008

    • Author(s)
      大森孝一
    • Organizer
      第33回日本外科系連合学会学術集会
    • Place of Presentation
      浦安市
    • Year and Date
      2008-06-12
  • [Presentation] 〔シンポジウム〕喉頭・気管の再生医療2008

    • Author(s)
      大森孝一
    • Organizer
      第109回日本耳鼻咽喉科学会総会・学術講演会
    • Place of Presentation
      大阪
    • Year and Date
      2008-05-17
  • [Presentation] Bio-engineered scaffold with fibroblasts for tracheal regeneration in rabbit model2008

    • Author(s)
      Okano W, Nomoto Y, Suzuki T,Nakamura T, Omori K
    • Organizer
      The 129th Annual Meeting of the American Laryngological Association Orlando
    • Place of Presentation
      USA
    • Year and Date
      2008-05-02
  • [Presentation] The investigation of the potentiality of the cell culture medium with autologous blood serum for cell transplantation therapy for injured vocal fold2008

    • Author(s)
      Kanemaru S, Nakamura T, Yamashita M, Umeda H, Oono T, Hirano S, Ito J, Omori K
    • Organizer
      The 88th Annual Meeting ofAmerican Broncho-EsophagologicalAssociation, Orlando
    • Place of Presentation
      USA
    • Year and Date
      2008-05-02
  • [Presentation] 〔Mini-Symposium〕Regenerative medicine for airway organs2008

    • Author(s)
      Omori K, Tada Y, Nakaura T, Kanemaru S, Suzuki T, Nomoto Y, Okano W
    • Organizer
      The 15th World Congress for Bronchoesophagology
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2008-04-01
  • [Presentation] 〔Mini-Symposium〕Bioengineered trachea with fibroblasts2008

    • Author(s)
      Nomoto Y, Okano W, Kbayashi K, Tada Y, Wada I, Nakamura T, WatanOmori K
    • Organizer
      The 15th World Congress for Bronchoesophagology
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2008-04-01
  • [Presentation] 〔Instruction Courses〕Tissue engineering for regenerative medicine2007

    • Author(s)
      Omori K
    • Organizer
      The 2007 American Academy of Otolaryngology-Head and Neck Surgery Foundation Annual Meeting & OTO EXPO
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2007-09-19
  • [Book] 耳鼻咽喉科・頭頸部外科領域の再生医療.「今日の耳鼻咽喉科・頭頸部外科治療指針(第3版)」(森山寛, 他編)2008

    • Author(s)
      大森孝一
    • Total Pages
      598-599
    • Publisher
      医学書院, 東京
  • [Remarks] 大森孝一 : 〔放送〕喉頭・気管領域の再生治療. ラジオNIKKEI「病学講座」2007年8月1日

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Published: 2010-06-10   Modified: 2016-04-21  

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