Development of high-speed swept source optical coherence tomography system and three-dimensional analysis of anterior eye segment structure

2009 Fiscal Year Final Research Report

• Project/Area Number: 19390439
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: University of Tsukuba
• Principal Investigator: OSHIKA Tetsuro University of Tsukuba, 大学院・人間総合科学研究科, 教授 (90194133)
• Co-Investigator(Kenkyū-buntansha): YASUNO Yoshiaki 筑波大学, 大学院・数理物質科学研究科, 助教 (10344871) ; KAWANA Keisuke 筑波大学, 大学院・人間総合科学研究科, 講師 (00436271) ; HIRAOKA Takahiro 筑波大学, 大学院・人間総合科学研究科, 講師 (30359575)
• Project Period (FY): 2007 – 2009
• Keywords: 光干渉断層計 / OCT / 前眼部 / Swept source

Research Abstract

We developed the world's first three-dimensional optical coherence tomography (OCT) which enables non-invasive stereoscopic observation of the inner structures of the anterior eye segment. We have started clinical application of this instrument as the fastest anterior segment OCT with ability to perform minute examination of the ocular tissue with deeper penetration. Non-contact investigations were conducted in areas such as qualitative and quantitative analysis of the anterior chamber angle, observation of the inner structure of the conjunctival bleb after glaucoma filtering surgery, quantitative analysis of anterior chamber depth and volume parameters, and assessment of corneal topography.

Research Products

• [Journal Article] Evaluation of trabeculectomy blebs using 3-dimensional cornea and anterior segment optical coherence tomography (2009)
  • Author(s): Kawana K, Kiuchi T, Yasuno T, Oshika T
  • Journal Title: Ophthalmology 116 Pages: 848-855
  • Peer Reviewed
• [Journal Article] Anterior ocular biometry using 3-dimensional optical coherence tomography (2009)
  • Author(s): Fukuda S, Kawana K, Yasuno Y, Oshika T
  • Journal Title: Ophthalmology 116 Pages: 882-889
  • Peer Reviewed
• [Journal Article] Investigation of post-glaucoma-surgery structures by three-dimensional and polarization sensitive anterior eye segment optical coherence tomography (2009)
  • Author(s): Yasuno Y, Yamanari M, Kawana K, Oshika T, Miura M
  • Journal Title: Optics Express 17 Pages: 3980-3996
  • Peer Reviewed
• [Journal Article] Investigation of multifocal choroiditis with panuveitis by three-dimensional high-penetration optical coherence tomography (2009)
  • Author(s): Yasuno Y, Okamoto F, Kawana K, Yatagai T, Oshika T
  • Journal Title: J Biophotonics 2 Pages: 435-441
  • Peer Reviewed
• [Journal Article] Three-dimensional anterior segment optical coherence tomography of filtering blebs after trabeculectomy (2008)
  • Author(s): Miura M, Kawana K, Iwasaki T, Kiuchi T, Oshika T, Mori H, Yamanari M, Makita S, Yatagai T, Yasuno Y
  • Journal Title: J Glaucoma 17 Pages: 193-196
  • Peer Reviewed
• [Journal Article] High-speed, swept-source optical coherence tomography : a three-dimensional view of anterior chamber angle recession (2007)
  • Author(s): Kawana K, Yasuno Y, Yatagai T, Oshika T
  • Journal Title: Acta Ophthalmol Scand 85 Pages: 684-685
  • Peer Reviewed
• [Journal Article] Three-dimensional optical coherence tomography of granular corneal dystrophy (2007)
  • Author(s): Miura M, Mori H, Watanabe Y, Usui M, Kawana K, Oshika T, Yatagai T, Yasuno Y
  • Journal Title: Cornea 26 Pages: 373-374
  • Peer Reviewed
• [Presentation] Discrimination of conjunctiva and sclera by analysis of local statistics of polarization sensitive optical coherence tomography images (2009)
  • Author(s): Miyazawa A, Yamanari M, Makita S, Miura M, Kawana K, Oshika T, Yasuno Y
  • Organizer: Association for Research in Vision and Ophthalmology
  • Place of Presentation: Fort Lauderdale, Florida, USA
  • Year and Date: 2009-05-05
• [Presentation] Comparison of two- and three-dimensional anterior segment optical coherence tomography in the evaluation of anterior chamber angle structures and parameters in two- and three-dimensional anterior segment optical coherence tomography (2009)
  • Author(s): Nakakuki N, Kawana K, Yasuno Y, Oshika T
  • Organizer: Association for Research in Vision and Ophthalmology
  • Place of Presentation: Fort Lauderdale, Florida, USA
  • Year and Date: 2009-05-05
• [Presentation] Improved visualization of trabecular meshwork by polarization sensitive optical coherence tomography (2009)
  • Author(s): Yasuno Y, Kawana K, Yamanari M, Miura M, Fukuda S, Oshika T
  • Organizer: Association for Research in Vision and Ophthalmology
  • Place of Presentation: Fort Lauderdale, Florida, USA
  • Year and Date: 2009-05-05
• [Presentation] 前眼部3次元光干渉断層計による円錐角膜の前房容積評価 (2009)
  • Author(s): 川名啓介, 福田慎一, 安野嘉晃, 大鹿哲郎
  • Organizer: 第23回角膜カンファランス, 第25回日本角膜移植学会
  • Place of Presentation: 大阪市
  • Year and Date: 2009-02-20
• [Presentation] Investigation of anterior chamber angle by swept-source polarization sensitive optical coherence tomography (2009)
  • Author(s): Yasuno Y, Yamanari M, Kawana K, Miura M, Makita S, Oshika T
  • Organizer: BiOS 2009/2
  • Place of Presentation: San Jose, USA
  • Year and Date: 2009-01-20
• [Presentation] 前眼部3次元光干渉断層計と Scheimpflug 型およびスリット型前眼部解析装置の比較 (2008)
  • Author(s): 宮井尚宏, 川名啓介, 安野嘉晃, 大鹿哲郎
  • Organizer: 第62回日本臨床眼科学会
  • Place of Presentation: 東京
  • Year and Date: 2008-10-24
• [Presentation] 前眼部光干渉断層計の強膜岬検出率比較 (2008)
  • Author(s): 中岫典子, 川名啓介, 安野嘉晃, 大鹿哲郎
  • Organizer: 第62回日本臨床眼科学会
  • Place of Presentation: 東京
  • Year and Date: 2008-10-24
• [Presentation] Three-dimensional investigation of anterior and posterior eye by optical coherence tomography (2008)
  • Author(s): Yasuno Y, Miura M, Oshika T
  • Organizer: Association for Research in Vision and Ophthalmology
  • Place of Presentation: Fort Lauderdale, Florida, USA
  • Year and Date: 2008-05-01
• [Presentation] Birefringence imaging of anterior eye by three-dimensional polarization sensitive anterior eye segment optical coherence tomography (2008)
  • Author(s): Yamanari M, Miura M, Kawana K, Iwasaki T, Oshika T, Yasuno Y
  • Organizer: Association for Research in Vision and Ophthalmology
  • Place of Presentation: Fort Lauderdale, Florida, USA
  • Year and Date: 2008-05-01
• [Presentation] Evaluation of clear corneal incision of cataract surgery using three dimensional corneal and anterior segment optical coherence tomography (2008)
  • Author(s): Fukuda S, Kawana K, Yasuno Y, Oshika T
  • Organizer: Association for Research in Vision and Ophthalmology
  • Place of Presentation: Fort Lauderdale, Florida, USA
  • Year and Date: 2008-05-01
• [Presentation] Evaluation of trabeculectomy bleb using three dimensional cornea and anterior segment optical coherence tomography (2008)
  • Author(s): Kawana K, Fukuda S, Sato M, Kiuchi T, Yasuno Y, Oshika T
  • Organizer: Association for Research in Vision and Ophthalmology
  • Place of Presentation: Fort Lauderdale, Florida, USA
  • Year and Date: 2008-05-01
• [Presentation] Anterior segment biometry with three-dimensional swept-source optical coherence tomography, Scheimpflug camera, scanning slit topography, and ultrasound pachymetry (2008)
  • Author(s): Moriya M, Fukuda S, Kawana K, Yasuno Y, Oshika T
  • Organizer: Association for Research in Vision and Ophthalmology
  • Place of Presentation: Fort Lauderdale, Florida, USA
  • Year and Date: 2008-05-01
• [Presentation] 前眼部3次元光干渉断層計による円錐角膜の急性水腫および全層角膜移植術評価 (2008)
  • Author(s): 福田慎一, 川名啓介, 安野嘉晃, 大鹿哲郎
  • Organizer: 第22回角膜カンファランス, 第24回日本角膜移植学会
  • Place of Presentation: 浦安市
  • Year and Date: 2008-02-28
• [Presentation] 前眼部3次元光干渉断層計による2種類の抗緑内障薬点眼後の涙液動態解析 (2008)
  • Author(s): 川名啓介, 福田慎一, 平岡孝浩, 大鹿哲郎, 安野嘉晃
  • Organizer: 第22回角膜カンファランス, 第24回日本角膜移植学会
  • Place of Presentation: 浦安市
  • Year and Date: 2008-02-28
• [Presentation] 前眼部3次元光干渉断層計による翼状片評価 (2008)
  • Author(s): 福田慎一, 川名啓介, 安野嘉晃, 大鹿哲郎
  • Organizer: 第31回日本眼科手術学会
  • Place of Presentation: 横浜市
  • Year and Date: 2008-02-01
• [Presentation] 前眼部3次元光干渉断層計によるレーザー虹彩切開術前後評価 (2008)
  • Author(s): 川名啓介, 福田慎一, 森谷充雄, 木内貴博, 安野嘉晃, 大鹿哲郎
  • Organizer: 第31回日本眼科手術学会
  • Place of Presentation: 横浜市
  • Year and Date: 2008-02-01
• [Presentation] Polarization-sensitive Fourier domain optical coherence tomography for the imaging the anterior segment disorder of the eyes (2007)
  • Author(s): Miura M, Yamanari M, Watabnabe Y, Mori H, Iwasaki T, Elsner AE, Kawana K, Oshika T, Yatagai T, Yasuno Y
  • Organizer: European Conferences on Biomedical Optics 2007
  • Place of Presentation: Munich, Germany
  • Year and Date: 2007-06-18
• [Presentation] Clinical application of high-speed swept-source three dimensional optical coherence tomography for analyzing anterior eye segments after glaucoma surgery (2007)
  • Author(s): Kawana K, Oshika T, Yasuno T, Yatagai T
  • Organizer: Association for Research in Vision and Ophthalmology
  • Place of Presentation: Fort Lauderdale, Florida, USA
  • Year and Date: 2007-05-07
• [Presentation] Anterior chamber angle assessment using anterior segment optical coherence tomography, ultrasound biomicroscopy, and rotating Scheimpflug camera (2007)
  • Author(s): Takahashi K, Kawana K, Oshika T
  • Organizer: Association for Research in Vision and Ophthalmology
  • Place of Presentation: Fort Lauderdale, Florida, USA
  • Year and Date: 2007-05-07
• [Presentation] Imaging polarimetry in anterior segment disorders with polarization-sensitive Fourier domain optical coherence tomography (2007)
  • Author(s): Iwasaki T, Miura M, Yamanari M, Watabnabe T, Mori H, Elsner AE, Kawana K, Oshika T, Yatagai T, Yasuno Y
  • Organizer: Association for Research in Vision and Ophthalmology
  • Place of Presentation: Fort Lauderdale, Florida, USA
  • Year and Date: 2007-05-07