Molecular Mechanisms of Innate Immunity in the Eye

2009 Fiscal Year Self-evaluation Report

• Project/Area Number: 19390440
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: MOCHIZUKI Manabu Tokyo Medical and Dental University, 大学院・医歯学総合研究科, 教授 (10010464)
• Project Period (FY): 2007 – 2010
• Keywords: 眼科学

Research Abstract

眼内自然免疫機構を解明する目的で、ヒト培養虹彩色素上皮(IPE)、ヒト培養角膜内皮(HCE)、眼色素上皮誘導制御性T細胞(PE-induced Tregs)らを用いてその抑制能について解析した。

Research Products

• [Journal Article] Human corneal endothelial cells expressing programmed death-ligand 1 (PD-L1) suppress PD-1^+ T helper 1 cells by a contact-dependent mechanism (2009)
  • Author(s): Sugita S, Usui Y, Hone S, Futagami Y, Yamada Y, Ma J, Kezuka T, Hamada H, Usui T, Mochizuki M, Yamagami. S.
  • Journal Title: Invest.Ophthalmol.Vis.Sci. 50 Pages: 263-272
• [Journal Article] Human iris pigment epithelium suppresses activation of bystander T cells via TGF□-TGF□ receptor interaction (2009)
  • Author(s): Horie S, Sugita S, Futagami Y, Kawaguchi T, Kamoi K, Shirato S, Mochizuki M.
  • Journal Title: Exp.Eye.Res. 88 Pages: 1033-1042
• [Journal Article] T cell suppression by programmed cell death 1 ligand 1 on retinal pigment epithelium during inflammatory conditions (2009)
  • Author(s): Sugita S, Usui Y, Horie S, Futagami Y, Aburatani H, Okazaki T, Honjo T, Takeuchi M, Mochizuki M.
  • Journal Title: Invest.Ophthalmol.Vis.Sci. 50 Pages: 2862-2870
• [Journal Article] Acquisition of T regulatory function in cathepsin L-inhibited T cells by eye-derived CTLA-2□ during inflammatory conditions (2009)
  • Author(s): Sugita S, Horie S, Nakamura O, Maruyama K, Takase H, Usui Y, Takeuchi M, Ishidoh K, Koike M, Uchiyama Y, Peters C, Yamamoto Y, Mochizuki M.
  • Journal Title: J Immunol. 183 Pages: 5013-5022
• [Journal Article] Iris pigment epithelium-inducing regulatory T cells suppress bystander T helper 1 cells via negative costimulatory signals (2009)
  • Author(s): Sugita S, Horie S, Yamada Y, Keino H, Usui Y, Takeuchi M, Mochizuki M.
  • Journal Title: Invest.Ophthalmol.Vis.Sci. (in press. [Epub ahead of print])
• [Journal Article] Mechanisms of immune suppression for CD8^+ T cells by human corneal endothelial cells via membrane-bound TGF□□ (2009)
  • Author(s): Yamada Y, Sugita S, Horie S, Yamagami S. Mochizuki M.
  • Journal Title: Invest.Ophthalmol.Vis.Sci. (in press. [Epub ahead of print])
• [Journal Article] Role of ocular pigment epithelial cells in immune privilege (2009)
  • Author(s): Sugita S
  • Journal Title: Arch.Immunol.Ther.Exp. 57 Pages: 263-268
• [Presentation] CTLA-2 alpha による眼血管新生抑制効果 (2009)
  • Author(s): 丸山和一, 米田一仁, 木下茂, 杉田直, 山本芳実
  • Organizer: 第43回日本眼炎症症学会
  • Place of Presentation: 大阪
  • Year and Date: 2009-07-10
• [Presentation] 山上聡角膜内皮細胞による膜結合型TGFを介した制御性T細胞誘導能 (2009)
  • Author(s): 山田由季子, 杉田直, 堀江真太郎, 望月學
  • Organizer: 第43回日本眼炎症症学会
  • Place of Presentation: 大阪
  • Year and Date: 2009-07-09
• [Presentation] Human retinal pigment epithelium-induced CD4^+CD25^+ regulatory T cells suppress activation of intraocular effector T cells (2009)
  • Author(s): Horie S, Sugita S, Futagami Y, Yamada Y, Mochizuki M.
  • Organizer: 10^<th> International Ocular Inflammation Society Congress
  • Place of Presentation: Prague
  • Year and Date: 2009-05-30
• [Presentation] シンポジュウム『眼免疫防御機構の不思議―色素上皮とぶどう膜―』 (2009)
  • Author(s): 杉田直
  • Organizer: 第113回日本眼科学会総会
  • Place of Presentation: 東京
  • Year and Date: 2009-04-17
• [Presentation] 竹内大インターフェロン-γ処理網膜色素上皮のPDL1副刺激分子の発現およびその機能 (2009)
  • Author(s): 堀江真太郎, 杉田直, 山田由季子, 二神百合, 望月學, 臼井嘉彦
  • Organizer: 第113回日本眼科学会総会
  • Place of Presentation: 東京
  • Year and Date: 2009-04-16
• [Book] 臨床免疫・アレルギー科(網膜色素上皮細胞由来CTLA-2aによるTGFb制御性T細胞誘導) (2009)
  • Author(s): 杉田直
  • Total Pages: 231-236