Molecular mechanisms of natural immunity in the eye

2010 Fiscal Year Final Research Report

• Project/Area Number: 19390440
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: MOCHIZUKI Manabu Tokyo Medical and Dental University, 大学院・医歯学総合研究科, 教授 (10010464)
• Co-Investigator(Kenkyū-buntansha): OHNO Kyouko 東京医科歯科大学, 大学院・医歯学総合研究科, 准教授 (30262174) ; SUGITA Sunao 東京医科歯科大学, 大学院・医歯学総合研究科, 講師 (10299456) ; TANAKA Akiko 東京医科歯科大学, 医学部附属病院, 助教 (60302874) ; SUGAMOTO Yoshiharu 東京医科歯科大学, 医学部附属病院, 助教 (20334419)
• Project Period (FY): 2007 – 2010
• Keywords: 自然免疫 / 眼虹彩色素上皮細胞 / 眼網膜色素上皮細胞 / 制御性T細胞 / 免疫調節分子機構

Research Abstract

To identify regional immune system in the eye, in vitro studies using ocular pigment epithelial cells (iris, ciliary body, retina) isolated from mouse were carried out. Iris pigment epithelial cells suppressed activated CD4 T cells via cell-to-cell contact through B7-2 on iris pigment epithelial cells, CTLA-4 on activated T cells, and TGF-b and CTLA-2a. In addition, ocular pigment epithelial cells have capacities to promote regulatory T cells and enhance its immune-regulatory activities.

Research Products

• [Journal Article] (2010)
  • Author(s): 望月學
  • Journal Title: Acta Ophthalmol 88 Pages: 292-299
• [Journal Article] (2010)
  • Author(s): Horie S, Sugita S, Futagami Y, Yamada Y, Mochizuki M
  • Journal Title: Clin Immunol
• [Journal Article] (2010)
  • Author(s): Sugita S, Horie S, Yamada Y, Keino H, Usui Y, Takeuchi M, Mochizuki M
  • Journal Title: Invest Ophthalmol Vis Sci 51 Pages: 2529-2536
• [Journal Article] (2010)
  • Author(s): Yamada Y, Sugita S, Horie S, Yamagami S, Mochizuki M
  • Journal Title: Invest Ophthalmol Vis Sci 51 Pages: 2548-2557
• [Journal Article] (2010)
  • Author(s): Yamada Y, Sugita S, Horie S, Yamagami S, Mochizuki M
  • Journal Title: Invest Ophthalmol Vis Sci 51 Pages: 2548-2557
• [Journal Article] (2009)
  • Author(s): Sugita S, Usui Y, Horie S, Futagami Y, Yamada Y, Ma J, Kezuka T, Hamada H, Usui T, Mochizuki M, Yamagami S
  • Journal Title: Invest Ophthalmol Vis Sci 50 Pages: 263-271
• [Journal Article] (2009)
  • Author(s): Horie S, Sugita S, Futagami Y, Kawaguchi T, Kamoi K, Shirato S, Mochizuki M
  • Journal Title: Exp Eye Res 88 Pages: 1033-1042
• [Journal Article] (2009)
  • Author(s): Sugita S, Usui Y, Horie S, Futagami Y, Aburatani H, Okazaki T, Honjo T, Takeuchi M, Mochizuki M
  • Journal Title: Invest Ophthalmol Vis Sci 50 Pages: 2862-2870
• [Journal Article] (2009)
  • Author(s): Sugita S, Horie S, Nakamura O, Maruyama K, Takase H, Usui Y, Takeuchi M, Ishidoh K, Koike M, Uchiyama Y, Peters C, Yamamoto Y, Mochizuki M
  • Journal Title: J Immunol 183 Pages: 5013-5022
• [Journal Article] (2009)
  • Author(s): 望月學
  • Journal Title: 日本眼科学会雑誌 113 Pages: 344-378
• [Journal Article] (2008)
  • Author(s): Sugita S, Shimizu N, Watanabe K, Mizukami M, Morio T, Sugamoto Y, Mochizuki M
  • Journal Title: Br J Ophthalmol 92 Pages: 928-932
• [Journal Article] (2008)
  • Author(s): Sugita S, Horie S, Nakamura O, Futagami Y, Takase H, Keino H, Aburatani H, Katunuma N, Ishidoh K, Yamamoto Y, Mochizuki M
  • Journal Title: J Immunol 181 Pages: 7525-7536
• [Journal Article] (2007)
  • Author(s): Futagami Y, Sugita S, Vega J, Ishida K, Takase H, Maruyama K, Aburatani H, Mochizuki M
  • Journal Title: J Immunol 178 Pages: 6994-7005
• [Journal Article] (2007)
  • Author(s): Sugita S, Takase H, Taguchi C, Mochizuki M
  • Journal Title: Invest Ophthalmol Vis Sci 48 Pages: 3246-3252
• [Journal Article] (2007)
  • Author(s): Sugita S, Futagami Y, Horie S, Mochizuki M
  • Journal Title: Exp Eye Res 85 Pages: 626-636
• [Presentation] (2010)
  • Author(s): 杉田直
  • Organizer: Symposium, ARVO 2010 Annual Meeting
  • Place of Presentation: Fort Lauderdale
  • Year and Date: 2010-05-05
• [Presentation] (2010)
  • Author(s): 杉田直, 堀江真太郎, 山田由季子, 望月學, 臼井嘉彦, 竹内大
  • Organizer: 第114回日本眼科学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2010-04-15
• [Presentation] (2009)
  • Author(s): 山田由季子, 杉田直, 堀江真太郎, 望月學, 山上聡
  • Organizer: 第43回日本眼炎症症学会
  • Place of Presentation: 大阪
  • Year and Date: 2009-07-10
• [Presentation] (2009)
  • Author(s): Horie S, Sugita S, Futagami Y, Yamada Y, Mochizuki M
  • Organizer: 10^<th> International Ocular Inflammation Society Congress
  • Place of Presentation: Prague(Austria)
  • Year and Date: 2009-05-30
• [Presentation] (2009)
  • Author(s): 杉田直
  • Organizer: シンポジウム.第113回日本眼科学会総会
  • Place of Presentation: 東京
  • Year and Date: 2009-04-17
• [Presentation] Regional immunity of the eye. (2009)
  • Author(s): 望月學
  • Organizer: 10^<th> International Congress of the Middle East African Council of Ophthalmology
  • Place of Presentation: Bahrain
  • Year and Date: 2009-03-29
• [Presentation] (2008)
  • Author(s): 杉田直, 堀江真太郎, 二神百合, 高瀬博, 望月學
  • Organizer: 第42回日本眼炎症学会
  • Place of Presentation: 東京
  • Year and Date: 2008-07-04
• [Presentation] (2008)
  • Author(s): 堀江真太郎, 杉田直, 二神百合, 山田由季子, 望月學
  • Organizer: 第42回日本眼炎症学会
  • Place of Presentation: 東京
  • Year and Date: 2008-07-04
• [Presentation] (2008)
  • Author(s): Sugita S, Futagami Y, Yamada Y, Horie S, Takase H, Mochizuki M
  • Organizer: Association for Research in Vision and Ophthalmology (ARVO) 2008 Annual Meeting
  • Place of Presentation: Fort Lauderdale(U.S.A.)
  • Year and Date: 2008-04-29
• [Presentation] (2008)
  • Author(s): Horie S, Sugita S, Futagami Y, Kawaguchi T, Shirato S, Mochizuki M
  • Organizer: ARVO, 2008 Annual Meeting
  • Place of Presentation: Fort Lauderdale(U.S.A.)
  • Year and Date: 2008-04-29
• [Presentation] 日本眼科学会学術奨励賞記念講演 (2008)
  • Author(s): 杉田直
  • Organizer: 第112回日本眼科学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2008-04-19
• [Presentation] (2008)
  • Author(s): 望月學
  • Organizer: 第112回日本眼科学会総会特別講演
  • Place of Presentation: 横浜
  • Year and Date: 2008-04-18
• [Remarks] ホームページ等