2009 Fiscal Year Final Research Report
Application of bionanocapsule on eye disease
| Project/Area Number |
19390443
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Ophthalmology
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
OGURO Nobuyuki Osaka University, 医学系研究科, 准教授 (00303967)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KURODA Shunichi 名古屋大学, 大学院・生命農学研究科, 教授 (60263406)
OTORI Yasumasa 大阪大, 医学系研究科, 講師 (40303953)
|
|---|
| Project Period (FY) |
2007 – 2009
|
| Keywords | バイオナノカプセル / ドラッグデリバリーシステム / 実験的ぶどう膜炎 / 視神経切断モデル / 血管内皮細胞 / 網膜神経節細胞 |
|---|
| Research Abstract |
We attempted to develop a new drug delivery system (DDS) targeting specific molecules, such as E-selectin or Thy1, with using anti-E-selectin or anti-Thy1 antibody conjugated bionanocapsule (BNC). The results in this study clearly demonstrated that this nano-device could be a gene deliver system targeting cells expressed these molecules. However, since level of protein expression by transferred Vector-gene was poor, we had to improve the method in the fusion process of BNC and DNA vector. This improvement made it possible to increase protein expression level significantly in vitro. Further in vivo study should be done to achieve clinical application of this DDS.
|
