2010 Fiscal Year Final Research Report
Basic and clinical investigation of cerebral and sacral neuromodulation in the field of pediatric surgical diseases
| Project/Area Number |
19390448
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatric surgery
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| Research Institution | Niigata University |
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Principal Investigator |
KUBOTA Masayuki Niigata University, 医歯学系, 教授 (50205150)
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| Co-Investigator(Kenkyū-buntansha) |
OKUYAMA Naoki 新潟大学, 医歯学系, 准教授 (00312736)
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| Project Period (FY) |
2007 – 2010
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| Keywords | 神経調節 / 高頻度磁気刺激 / 仙骨神経 / 鎖肛 / ヒルシュスプルング病 / 慢性便秘 |
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| Research Abstract |
Neuromodulation is a recent technique where an electric current is applied to the cerebral cortex or the sacral nerves to improve neural disturbances. Repetitive magnetic stimulation represents a non-invasive technique to painlessly induce an electric current inside the body. Based on the animal studies, one treatment course consisted of stimulation delivered at 15Hz for 5 seconds 10 times over an interval of one minute. We performed sacral magnetic stimulation (SMS) in post-operative pediatric patients withoug any harmful events (anorectal anomalies 24 case, Hirschspurung disease 10 cases, and chronic constipation 10 cases). In three post-operative pediatric patients with severe bowel or bladder dysfunction refractory to conservative treatments, SMS induced a remarkable improvement, thereby suggesting usefulness of SMS as a new treatment modality of neuromodulation.
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[Journal Article] A case of choledochal cyst associated with a lymphatic infiltration of a hyperplastic gallbladder epithelium2009
Author(s)
Hirayama Y, Kubota M, Hasegawa G, Okuyama N, Ohtaki M, Kobayashi K, Tsukada M, Sato K, Nishikura K, Naito M, Ajioka Y
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Journal Title
J Pediatr Surg 44
Pages: 831-835
Peer Reviewed
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[Journal Article] A 2-year-old boy with a stage III yolk sac tumor occurring in an intra-abdominal retained testis2009
Author(s)
Hirayama Y, Kubota M, Imamura M, Imai C, Okuyama N, Tsukada M, Kobayashi K, Sato K, Takachi T, Iwafuchi H, Uchiyama M
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Journal Title
J Pediatr Surg 44
Pages: 2395-2398
Peer Reviewed
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[Journal Article] Sacral parasite with Histopathological features of an unequally conjoined twin2007
Author(s)
Hirayama Y, Kubota M, Kakita A, Kawasaki T, Hasegawa G, Tanaka S, Ohtaki M, Yamazaki S, Okuyama, Yagi M, Naito M
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Journal Title
Pediatr Surg Int 23
Pages: 715-720
Peer Reviewed
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