2009 Fiscal Year Final Research Report
Sorting of cells that have the ability to regenerate complete skin
| Project/Area Number |
19390455
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Plastic surgery
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| Research Institution | Keio University |
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Principal Investigator |
KISHI Kazuo Keio University, 医学部, 講師 (40224919)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAJIMA Tatsuo 慶應義塾大学, 医学部, 教授 (40095633)
久保田 義顕 慶應義塾大学, 医学部, 講師 (50348687)
勝部 憲一 東京医科歯科大学, 医歯(薬)学総合研究科, 講師 (20233760)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 皮膚 / 再生 / 付属器 / 細胞 |
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| Research Abstract |
Murine fetal dermal cells have the ability to regenerate complete skin when co-transplanted with fetal epidermal cells. This potential of regenerative ability disappear after they grew up. The ability to regenerate skin can be substituted using skin derived precursors (skps). As such, some cells, remain in the adult tissue and may possess the ability to regeneration. In order to identify and sorting cells that have the ability to regenerate skin, we used MACS using various cell surface markers which expressed rich in fetal dermal cells but not fascial cells. By co-transplanting cells of these cells with fetal epidermal cells, partial regeneration of skin including hair could be observed, but the population was low. Some damage to the cells during separation of the low population of the cells were thought to be a cause.
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[Journal Article] E-cadherin expression in the subepithelial nevus cells of the giant congenital nevocellular nevi (GCNN) correlates with their migration ability in vitro.2008
Author(s)
Matsuda N, Katsube K, Mikami S, Katsuki Y, Iseki H, Mukai M, Yamaguchi A, Takano Y, Nakajima T, Nakajima H, Kishi K
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Journal Title
J Dermatol Sci 52(1)
Pages: 21-30
Peer Reviewed
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