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2009 Fiscal Year Final Research Report

Pathophysiological analysis for patients with anoxic coma after cardiopulmonary arrest.

Research Project

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Project/Area Number 19390459
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Emergency medicine
Research InstitutionOsaka University

Principal Investigator

SHIOZAKI Tadahiko  Osaka University, 医学系研究科, 助教 (60278687)

Co-Investigator(Kenkyū-buntansha) SUGIMOTO Hisashi  大阪大学, 名誉教授 (90127241)
OGURA Hiroshi  大阪大学, 医学系研究科, 講師 (70301265)
TASAKI Osamu  大阪大学, 医学系研究科, 助教 (90346221)
MATSUMOTO Naoya  大阪大学, 医学部附属病院, 助教 (50359808)
Co-Investigator(Renkei-kenkyūsha) TANAKA Hiroshi  順天堂大学, 医学部, 教授 (90252676)
Project Period (FY) 2007 – 2009
Keywords心肺蘇生 / 脳内酸素飽和度 / 脳蘇生 / 蘇生後脳症 / 脳低温療法
Research Abstract

In clinical study, we monitored bilateral regional cerebral oxygen saturation using near infrared spectroscopy (the TOS-96) during cardiopulmonary resuscitation continuously just after they arrived at hospital. Our studies suggest that extracorporeal cardiopulmonary resuscitation may improve regional cerebral oxygen saturation in patients with out-of-hospital cardiac arrest and their neurological outcome. In animal studies, using a gerbil model of global ischemia-reperfusion, we assessed the effects of hypothermia on physiological parameters and evaluated the optimal timing for induction of hypothermia to achieve a better survival rate. Under normothermic cerebral ischemia, the survival rate was dramatically decreased by induction of 15 to 20 minutes of ischemia. Induction of hypothermia significantly improved the survival rate only when induction of hypothermia occurred less than 10 minutes after ischemic onset.

  • Research Products

    (18 results)

All 2010 2009 2008 2007 Other

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (11 results)

  • [Journal Article] Incidence and outcomes of out-of-hospital cardiac arrest with shockresistant ventricular fibrillation : Data from a large population-based cohort.2010

    • Author(s)
      Sakai T, Tasaki O (3), Sugimoto H (18), 等19名
    • Journal Title

      Resuscitation 81

      Pages: 956-961

    • Peer Reviewed
  • [Journal Article] Evaluation of posttraumatic venous sinus occlusion with CT venography.2009

    • Author(s)
      Fujii Y, Shiozaki T (4), Sugimoto H (8), 等8名
    • Journal Title

      J Trauma 66

      Pages: 1002-1006

    • Peer Reviewed
  • [Journal Article] Comparison of neurological outcomes following witnessed out-of-hospital ventricular fibrillation defibrillated with either biphasic or monophasic automated external defibrillators.2009

    • Author(s)
      Kajino K, Shimazu T, Sugimoto H (9), 等9名
    • Journal Title

      Emerg Med J 26

      Pages: 492-496

    • Peer Reviewed
  • [Journal Article] Prognostic indicators and outcome prediction model for severe traumatic head injury.2009

    • Author(s)
      Tasaki O (1), Shiozaki T (2), Sugimoto H (8), 等8名
    • Journal Title

      J Trauma 66

      Pages: 304-308

    • Peer Reviewed
  • [Journal Article] Subsequent ventricular fibril-lation and survival in out-of-hospital cardiac arrests presenting with PEA or asystole.2008

    • Author(s)
      Kajino K, Shimazu T, Sugimoto H (9), 等9名
    • Journal Title

      Resuscitation 79

      Pages: 34-40

    • Peer Reviewed
  • [Journal Article] Effects of Timing and Duration of Hypothermia on Survival in an Experimental Gerbil Model of Global Ischemia.

    • Author(s)
      Noguchi K, Shiozaki T (3), Seiyama A, 等8名
    • Journal Title

      Resuscitation in press

    • Peer Reviewed
  • [Journal Article] Effectiveness of new "Mobile AED Map" to find and retrieve an AED : a randomized controlled trial.

    • Author(s)
      Sakai T, Shiozaki T (10), Shimazu T, 等13名
    • Journal Title

      Resuscitation in press

    • Peer Reviewed
  • [Presentation] Assessment of the benefit of extracorporeal life-support for patients with cardiac arrest in terms of cerebral oxygen saturation.2010

    • Author(s)
      Y Nakahori, K Shimizu, T Shiozaki, M Ohnishi, Y Nakagawa, O Tasaki, H Ogura, Y Kuwagata, T Shimazu
    • Organizer
      American heart association resuscitation science symposium.
    • Place of Presentation
      Chicago, U.S.A.
    • Year and Date
      20101113-20101117
  • [Presentation] Advanced treatments for Shock-resistant ventricular fibrillation at Critical Care Medical Centers : the Utstein Osaka Project.2010

    • Author(s)
      T Sakai, T Iwami, T Kawamura, T Kitamura, Y Hayashi, T Nishiuchi, Y Ohishi, H Rinka, K Kajino, O Tasaki, T Shimazu
    • Organizer
      American heart association resuscitation science symposium.
    • Place of Presentation
      Chicago, U.S.A.
    • Year and Date
      20101113-20101117
  • [Presentation] Effectiveness Of An "AED Map On A Mobile Web" System : A Randomized Controlled Trial.2009

    • Author(s)
      T Sakai, T Iwami, K Kajino, Tetsuhisa K, Chika N, Hiroshi T, Seishiroh M, Takashi K, Taro I, Tasaki O, Shiozaki T, Ogura H, Kuwagata Y
    • Organizer
      American Heart Association (AHA) Scientific Sessions
    • Place of Presentation
      Orland, U.S.A.
    • Year and Date
      20091114-20091118
  • [Presentation] The sequential changes in rSO-2. during cardio-pulmonary resuscitation.2009

    • Author(s)
      Nakahori Y, Shimizu K, Shiozaki T, Ogura H, Tasaki O, Kuwagata Y, Sugimoto H, Nakamori Y, Fujimi S, Ikeuchi H
    • Organizer
      Society of critical care medicine's 38th critical care congress.
    • Place of Presentation
      Nashville, Tennessee, U.S.A.
    • Year and Date
      20090131-20090204
  • [Presentation] Prognostic indications and outcome prediction model for patients with return of spontaneous circulation from caldiopulmonary arrest. -OSAKA UTSTEIN PROJECT-.2009

    • Author(s)
      Hayakawa K, Tasaki O, Hamasaki T, Kajino K, Shimizu K, Shiozaki T, Ogura H, Kuwagata Y, Sugimoto H
    • Organizer
      Society of critical care medicine's 38th critical care congress.
    • Place of Presentation
      Nashville, Tennessee, U.S.A.
    • Year and Date
      20090131-20090204
  • [Presentation] Neurological outcome of cardiac arrest patients treated with percutaneous cardiopulmonary support (PCPS).2009

    • Author(s)
      Shimizu K, Ogura H, Tasaki O, Hayakawa K, Nakahori Y, Kuwagata Y, Sugimoto H
    • Organizer
      Society of critical care medicine's 38th critical care congress.
    • Place of Presentation
      Nashville, Tennessee, U.S.A.
    • Year and Date
      20090131-20090204
  • [Presentation] Incidence and Outcomes of Out-of-Hospital Cardiac Arrest with Shock-resistant Ventricular Fibrillation in Osaka : Data from a Large Population-based Cohort.2009

    • Author(s)
      T Sakai, T Iwami, K Kajino, O Tasaki, T Nishiuchi, Y Hayashi, H Ikeuchi, A Hiraide, T Irisawa, T Kawamura, H Sugimoto.
    • Organizer
      International Resuscitation Science Symposium.
    • Place of Presentation
      Osaka, Japan.
    • Year and Date
      2009-03-19
  • [Presentation] Evaluation of posttraumatic venous sinus occlusion with CT venography.2008

    • Author(s)
      Fujii Y, Tasaki O, Yoshiya K, Shiozaki T, Ogura H, Kuwagata Y, Sugimoto H, Sumi Y
    • Organizer
      American Association for the Surgery of Trauma 16^(th) Meeting.
    • Place of Presentation
      Maui, Hawaii, U.S.A.
    • Year and Date
      20080924-20080927
  • [Presentation] Incidence and Outcomes of Out-of-Hospital Cardiac Arrest with Shock-resistant Ventricular Fibrillation in Osaka : Data from a Large Population-based Cohort.2008

    • Author(s)
      T Sakai, T Iwami, K Kajino, O Tasaki, T Nishiuchi, Y Hayashi, H Ikeuchi, A Hiraide, T Irisawa, T Kawamura, H Sugimoto.
    • Organizer
      American Heart Association (AHA) Scientific Sessions
    • Place of Presentation
      New Orleans, U.S.A.
    • Year and Date
      20080908-20080912
  • [Presentation] Subsequent VF is Associated with Better Outcomes from Out-of-Hospital Cardiac Arrests with Initial Non-shockable Rhythms. population-based Utstein Study In Osaka, Japan.2007

    • Author(s)
      K Kajino, T Iwami, Robert A.Berg, O Tasaki, T Kawamura, H Nonogi, T Nishiuchi, Y Hayashi, H Ikeuchi, H Tanaka, Ti Shimazu, A Hiraide, H Sugimoto
    • Organizer
      American Heart Association Scientific Sessions 2007.
    • Place of Presentation
      Orlando, U.S.A.
    • Year and Date
      20071103-20071107
  • [Presentation] Evaluation of abdominal blood flow during chest compression in cardiac arrest patients using enhanced computed tomography (CT).2007

    • Author(s)
      K.Shimizu, Y.Oode, H.Ogura, A.Matsushima, O.Tasaki, T.Shiozaki, Y.Kuwagata, T.Shimazu, H.Sugimoto
    • Organizer
      American Heart Association Scientific Sessions 2007.
    • Place of Presentation
      Orlando, U.S.A.
    • Year and Date
      20071103-20071107

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Published: 2012-01-26   Modified: 2016-04-21  

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