2009 Fiscal Year Final Research Report
Activation of endogenous neural stem cells using choroid plexus epithelial cells aimed at a new therapy for central nervous system injury
| Project/Area Number |
19390460
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Emergency medicine
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| Research Institution | Osaka University |
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Principal Investigator |
MATSUMOTO Naoya Osaka University, 医学部・附属病院, 助教 (50359808)
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| Co-Investigator(Kenkyū-buntansha) |
SUGIMOTO Hisashi 大阪大学, 医学系研究科, 名誉教授 (90127241)
KUWAGATA Yasuyuki 大阪大学, 医学系研究科, 准教授 (50273678)
OGURA Hiroshi 大阪大学, 医学系研究科, 講師 (70301265)
SHIOZAKI Tadahiko 大阪大学, 医学系研究科, 助教 (60278687)
TASAKI Osamu 大阪大学, 医学系研究科, 助教 (90346221)
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| Co-Investigator(Renkei-kenkyūsha) |
IDE Chizuka 藍野大学, 医療保健学部, 教授 (70010080)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 脈絡叢 / 脳脊髄液 / 細胞移植 / 脳梗塞 / 神経保護 / 神経再生 / 成長因子 |
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| Research Abstract |
We demonstrated that the injection of cultured choroid plexus epithelial cells (CPECs) through cerebrospinal fluid (CSF) suppressed the extension of ischemic brain injury against a rat model of cerebral infarction. Anti-inflammatory, anti-apoptotic and anti-oxidative effects were involved in the neuroprotective mechanisms. It was considered that a variety of neurotrophic and/or growth factors were secreted from the CPECs into the CSF and prevented the ischemic brain injury. In addition, the CPECs transplantation activated neural stem cells, enhancing the neuronal differentiation. In vitro experiments suggested that hypoxic stress itself elicited the ability of CPECs to promote cerebral protection and regeneration.
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[Journal Article] Transplantation of cultured choroid plexus epithelial cells via cerebrospinal fluid shows prominent neuroprotective effects against acute ischemic brain injury in the rat.2010
Author(s)
松本直也, Taguchi A., Kitayama H., Watanabe Y., Ohta M., Yoshihara T., Itokazu Y., Dezawa M., Suzuki Y., 杉本壽, Noda M., Ide C.
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Journal Title
Neurosci.Lett. 469
Pages: 283-288
Peer Reviewed
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[Journal Article] RECK modulates Notch signaling during cortical neurogenesis by regulating ADAM10 activity.2007
Author(s)
Muraguchi T., Takegami Y., Ohtsuka T., 松嶋麻子, Chandana EP, Omura A, Miki T., Takahashi R., 松本直也, Ludwig A., Noda M., Takahashi C.
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Journal Title
Nat.Neurosci. 10
Pages: 838-845
Peer Reviewed
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[Journal Article] Neuroprotective effect of bone marrow-derived mononuclear cells promoting functional recovery from spinal cord injury.2007
Author(s)
Yoshihara T., Ohta M., Itokazu Y., 松本直也, Dezawa M., Suzuki Y., 田中裕, Watanabe Y., Adachi Y., Ikehara S., 杉本壽, Ide C.
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Journal Title
J.Neurotrauma. 24
Pages: 1026-1036
Peer Reviewed
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