2009 Fiscal Year Final Research Report
Development of new therapeutic drugs for inflammatory bone destruction by the CIAM compound, a new TNF receptor antagonist.
| Project/Area Number |
19390471
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
OHYA Keiichi Tokyo Medical and Dental University, 医歯学総合研究科, 教授 (10126211)
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| Co-Investigator(Kenkyū-buntansha) |
AOKI Kazuhiro 東京医科歯科大学, 医歯学総合研究科, 准教授 (40272603)
TAKAHASHI Mariko 東京医科歯科大学, 歯学部, 技術職員 (90334440)
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| Co-Investigator(Renkei-kenkyūsha) |
JIMI Eijiro 九州歯科大学, 歯学部, 教授 (40276598)
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| Project Period (FY) |
2007 – 2009
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| Keywords | TNF受容体 / 骨吸収 / RANK / RANKL / 破骨細胞 / NF-κB / 骨吸収阻害 / 低Ca食飼育食マウス |
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| Research Abstract |
The cavity-induced allosteric modification (CIAM) compound binds to the cavity located near by the specific loop of the ligand binding site of the TNF receptor and thus inhibits the function of TNF. This study was undertaken to clarify the possibility in which the CIAM compound inhibits the proliferation of the osteoclasts and decreases bone resorption. The CIAM compound inhibited the osteoclast formation and finally increased bone formation. In addition, the compound inhibited the decrease of bone formation which accompanied with the inflammation. These results indicated that the CIAM compound is a new candidate drug both for the inhibitor of bone resorption and for the stimulator of bone formation induced by the inflammatory reactions.
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[Journal Article] The Pivotal role of the alternative NF-κB pathway in maintenance of basal bone homeostasis and osteoclastogenesis2009
Author(s)
Soysa N, Alles N, Weih D, Lovas A, Mian H, Shimokawa H, Yasuda H, Weih F, Jimi E, Ohya K, Aoki K
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Journal Title
J Bone Miner Res, Published on 14^<th> December
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[Journal Article] Processing of the NF-β2 Precursor, p100, to p52 is Critical for RANKL-Induced Osteoclast Differentiation2009
Author(s)
Maruyama T, Fukushima H, Nakao K, Shin M, Yasuda H, Weih F, Doi T, Aoki K, Alles N, Ohya K, Hosokawa R, Jimi E
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Journal Title
J Bone Miner Res published on 14^<th> December
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[Journal Article] Cathepsin K-Dependent Toll-Like Receptor 9 Signaling Revealed in Experimental Arthritis2008
Author(s)
Asagiri M, Hirai T, Kunigami T, Kamano S, Gober H-J, Okamoto K, Nishikawa K, Latz E, Golenbock D. T, Aoki K, Ohya K, Imai Y, Morishita Y, Miyazono K, Kato S, Saftig P, Takayanagi H
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Journal Title
Science Vol. 319
Pages: 624-627
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