2009 Fiscal Year Final Research Report
Effects of Notch Signaling on the Pulpal Cell Differentiation and the Horizon of Pulpal Regeneration by Regulation of Notch Signaling
| Project/Area Number |
19390481
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Conservative dentistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
KAWASHIMA Nobuyuki Tokyo Medical and Dental University, 大学院・医歯学総合研究科, 助教 (60272605)
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| Co-Investigator(Kenkyū-buntansha) |
KATSUBE Kenichi 東京医科歯科大学, 大学院・医歯学総合研究科, 講師 (20233760)
SAKAMOTO Kei 東京医科歯科大学, 大学院・医歯学総合研究科, 助教 (00302886)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 歯髄細胞 / 象牙芽細胞 / 分化 / Notch / 未分化間葉系細胞 / Hey1 |
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| Research Abstract |
A numerous factors are involved in the course of odontoblastic differentiation. We revealed the importance of Notch signaling in the osteoblastic differentiation, suggesting that the Notch signaling may one of the essential factors to regulate the differentiation of mesenchymal stromal cells into hard tissue forming cells. In the pulp cells, Notch signaling took a central role of odontoblastic differentiation, and active Notch signaling induced pulp cells remained undifferentiated. Hey1 was a major transcriptional factor in the Notch signaling in the osteo/odonto-blastic differentiation, and enforced expression of Hey1 in the pulp cells were disturbed their odontoblastic differentiation.
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Research Products
(37 results)
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[Journal Article] Kinetics of RANKL, RANK and OPG expressions in experimentally-induced rat periapical lesions.2007
Author(s)
Kawashima N., Suzuki N., Yang G., Ohi C., Okuhara S., Kawanishi H., Suda H.
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Journal Title
Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology 103
Pages: 707-711
Peer Reviewed
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[Presentation] Expression of Mef2c in Murine Odontoblsts.2010
Author(s)
N Kawashima, J Xu, N Suzuki, M Zhou, K Takimoto, Y Koizumi, M Yamamoto, A Salima, S Takahashi, H Suda
Organizer
8th World Endodontic Congress
Place of Presentation
in Athens, Greece
Year and Date
20101006-20101009
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[Presentation] Wnt Signaling in Odontoblast Differentiation Induced by BMP.2010
Author(s)
Y Koizumi, N Kawashima, K Takimoto, S Takahashi, J Xu, N Suzuki, M Zhou, M Yamamoto, A Salima, T Sugiyama, H Suda
Organizer
8th World Endodontic Congress
Place of Presentation
in Athens, Greece
Year and Date
20101006-20101009
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[Presentation] Promotive effects of Sp7 on Dspp expression.2010
Author(s)
N Kawashima, J Xu, T Iwata, S Takahashi, Y Koizumi, K Takimoto, Z Mengyu, C Ohi, N Suzuki, T Sugiyama, H Suda
Organizer
89th IADR General Session & Exhibition in Barcelona
Place of Presentation
Spain
Year and Date
20100714-20100717
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[Presentation] Expression of Sp7 in the rat dental pulp.2009
Author(s)
Kawashima N., Zhou M., Takimoto K., Koizumi Y., Ohi C., Takahashi S., Suzuki N., Suda H.
Organizer
2009 Autumn Scientific Meeting of Korean Academy of Conservative Dentistry, Ramada Plaza
Place of Presentation
Jeju, Korea
Year and Date
2009-11-13
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[Presentation] Notch Signaling in the Dental Pulp.2008
Author(s)
Kawashima N, Takahashi S, Okuhara S, Ohi C, Sun H, Wang H, Xu J, Katsube K, Arany S, Nakata A, Sugiyama T, Suda H,
Organizer
ADR General Session & Exhibition Metro Toronto Convention Centre
Place of Presentation
ON, Canada
Year and Date
20080702-20080705
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