2009 Fiscal Year Final Research Report
Analysis of proteins accumulated onto octacalcium phosphate and the related calcium phosphate crystals
| Project/Area Number |
19390490
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
補綴理工系歯学
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| Research Institution | Tohoku University |
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Principal Investigator |
SUZUKI Osamu Tohoku University, 大学院・歯学研究科, 教授 (60374948)
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| Co-Investigator(Kenkyū-buntansha) |
KAMAKURA Shinji 東北大学, 大学院・医工学研究科, 教授 (80224640)
KAMIIE Junichi 麻布大学, 獣医学部, 講師 (10400269)
ANMIIE Takahisa 東北大学, 大学院・歯学研究科, 助教 (30398466)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 生体材料 / リン酸オクタカルシウム(OCP) / 骨再生 / 結晶配向 / 成長因子 |
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| Research Abstract |
Synthetic octacalcium phosphate (OCP) enhances bone formation and accumulates circulating serum proteins on its surface if implanted in bone defect. The rat serum proteins accumulated on OCP in vitro preparation were analyzed by proteomic approaches using liquid chromatography-tandem mass spectrometry (LC-MS/MS). Over 100 proteins were detected from OCP surface as cellular and extracellular components. The extracellular components were categorized into molecular function, biological process and intracellular elements based on Protein ANalysis THrough Evolutionary Relationships classification system.
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