Protective effect on stress-related memory deficits by chewing

2009 Fiscal Year Final Research Report

• Project/Area Number: 19390493
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: 補綴理工系歯学
• Research Institution: Seijoh University
• Principal Investigator: WATANABE Kazuko Seijoh University, リハビリテーション学部, 教授 (50140413)
• Co-Investigator(Kenkyū-buntansha): KARASAWA Nobuyuki 星城大学, リハビリテーション学部, 教授 (70148287) ; KUBO Kin-ya 星城大学, リハビリテーション学部, 教授 (00329492) ; ONOZUKA Minoru 神奈川歯科大学, 歯学部, 教授 (90084780) ; SASAGURI Kin-ichi 神奈川歯科大学, 歯学部, 講師 (10235286) ; KIMU Wanze 神奈川歯科大学, 歯学部, 特別研究員 (50434395)
• Project Period (FY): 2007 – 2009
• Keywords: チューイング / ストレス / 記憶障害・マウス

Research Abstract

A new method for measuring method of stress indicator, which is measurable in a slightamount of blood andshort time, had been developed at the beginning. Mild restrain stress induded a alight decrease of leucocyte number and shortening fibrin clotting time , but variability was quite-variable and whole volume of blood was necessary in mice, which is suitable for behavioral analysis. Spontaneous chewing behavior was induced during mild restrain stress and enhanced learning effect in the morris water maze test.

Research Products

• [Journal Article] Bruxisum affects stress responses in stressed rats. (2010)
  • Author(s): Sato C, Sato S, Takashina H, IshiiH, Onozuka M, Sasaguri K.
  • Journal Title: Clin Oral Investig 14 Pages: 153-160
  • Peer Reviewed
• [Journal Article] Chewing under restraint stress inhibits the stress-induced suppression of cell birth in the dentate gyrus of aged SAMP8 mice. (2009)
  • Author(s): Kubo KY, Sasaguri K, Ono Y, Yamamoto T, Takahashi T, Watanabe K, Karasawa N, Onozuka M
  • Journal Title: Neurosci Lett 463 Pages: 109-113
  • Peer Reviewed
• [Journal Article] Effects of chewing in working memory processing (2008)
  • Author(s): Hirano Y, Obata T, Kashikura K, Nonaka H, Tachibana A, Ikehira H, Onozuka M
  • Journal Title: Neurosci Lett 436 Pages: 189-92
  • Peer Reviewed
• [Journal Article] Changes in GFAP-immunoreactive astrocytes-induced by the bite-raised condition in aged SAMP8 mice (2008)
  • Author(s): Ichihashi Y, Arakawa Y, Iinuma M, Tamura Y, Kubo K, Iwaku F, Takahashi T, Karasawa N, Nagatsu I, Onozuka M
  • Journal Title: Biogenic Amines 22 Pages: 39-48
  • Peer Reviewed
• [Journal Article] The bite-raised condition in aged SAMP8 mice induces dendritic spine changes in the hippocampal region (2008)
  • Author(s): Kubo K, Kojo A, Yamamoto T, Onozuka M
  • Journal Title: Neurosci Lett 441 Pages: 141-4
  • Peer Reviewed
• [Journal Article] Chewing ameliorates stress- induced suppre-ssion of hippocampal long-term potentia- tion (2008)
  • Author(s): Ono Y, Kataoka T, Miyake S, Cheng SJ, Tachibana A, Sasaguri KI, Onozuka M
  • Journal Title: Neuroscience 154 Pages: 1352-9
  • Peer Reviewed
• [Journal Article] Occlusal disharmony attenuates glucocortical negative feedback in aged SAMP8 mice (2007)
  • Author(s): Ichihashi Y, Arakawa Y, Iinuma M, Tamura Y, Kubo K, Iwaku F, Sato Y, Onozuka M
  • Journal Title: Neurosci Lett 427 Pages: 71-76
• [Journal Article] Occlusal disharmony induces spatial memory impairment and hippocampal neuron degeneration via stress in SAMP8 mice. (2007)
  • Author(s): Kubo KY, Yamada Y, Iinuma M, Iwaku F, Tamura Y, Watanabe K, Nakamura H, Onozuka M.
  • Journal Title: Neurosci Lett. 414 Pages: 188-191
• [Presentation] Chewing suppresses stress-induced phosphorylation of mitogen-activated protein kinases in the periaqueductal gray (2009)
  • Author(s): Yamada K, Ono Y, Yamamoto T, Onozuka M
  • Organizer: 第32回神経科学会
  • Place of Presentation: 名古屋国際会議場(名古屋)
  • Year and Date: 2009-09-17
• [Presentation] Chewing is involved in cel generation in the aged hippocampus dentate gurus (2009)
  • Author(s): Kubo K, Sasaguri, KI, Kimura K, Watanabe K, Onozuka M
  • Organizer: 第32回神経科学会
  • Place of Presentation: 名古屋国際会議場(名古屋)
  • Year and Date: 2009-09-17
• [Presentation] Chewing ameliorates stress- suppressed hippcampal CA1-LTP via activation of histamine H1 receptor (2009)
  • Author(s): Ono Y, Kataoka T, Miyake S, Sasaguri KI, Sato S, Onozuka M
  • Organizer: 第32回神経科学会
  • Place of Presentation: 名古屋国際会議場(名古屋)
  • Year and Date: 2009-09-17
• [Presentation] Amelioration of stress-reduced CaMKII-dependent hippocampal protein phosphorylation by chewing (2008)
  • Author(s): Iwamoto M, Kato K, Sasagurti TI, Watanabe K, Sato S, Onozuka M
  • Place of Presentation: 東京国際フォーラム(東京)
  • Year and Date: 2008-07-11
• [Presentation] Chewing and amygdaloid response to stress (2008)
  • Author(s): Niwa M, Hirano Y, OtsukaT, Watanabe K, Onozuka M
  • Organizer: 第31回神経科学会
  • Place of Presentation: 東京国際フォーラム(東京)
  • Year and Date: 2008-07-09
• [Presentation] Chewing-related neuronal mechanism under stress condition (2007)
  • Author(s): Kim W, Tachibana A, Otsuka T, Hirano Y, Kubo KY, Ono Y, Nakamura H, Karasawa N, Onozuka M, Watanabe K
  • Organizer: 30回日本神経科学大会
  • Place of Presentation: パシフィコ横浜(横浜)
  • Year and Date: 2007-09-11
• [Presentation] Ameliorative effect of biting on the stress-attenuated hippocampal memory process : a Morris water Maze study (2007)
  • Author(s): Miyake S, Ono Y, Kataoka T, Kim W, Sasaguri KI, Watanabe K, Sato S, Onozuka M
  • Organizer: 第30回日本神経科学大会
  • Place of Presentation: パシフィコ横浜(横浜)
  • Year and Date: 2007-09-11
• [Presentation] Ameliorative effect of biting on the stress-attenuated hippocampal memory process : a CA1-LTP study (2007)
  • Author(s): Ono Y, Miyake S, Kataoka T, Sasaguri K, Sato S, Watanabe K, Onozuka M
  • Organizer: 第30回日本神経科学大会
  • Place of Presentation: パシフィコ横浜(横浜)
  • Year and Date: 2007-09-11
• [Book] Involvement of dysfunctional mastication in cognitive system deficits in the mouse, In Nover Trends in Brain Science (2008)
  • Author(s): Watanabe K, et al.
  • Total Pages: 115-180
  • Publisher: Springer
• [Book] Interactions between chewing and brain activity in humans, In Nover Trends in Brain science (2008)
  • Author(s): Onozuka M, Hirano Y, Tachibana A, Kim W, Ono Y, Sasaguri K, Kubo K, Niwa M, Kanematsu K, Watanabe K
  • Total Pages: 99-114
  • Publisher: Springer