2009 Fiscal Year Final Research Report
New hypoxia PET imaging as a therapeutic strategy for the treatment of oral cancer
| Project/Area Number |
19390506
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
KITAGAWA Yosimasa Hokkaido University, 大学院・歯学研究科, 教授 (00224957)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAZAKI Yutaka 北海道大学, 大学病院, 講師 (90250464)
TAMAKI Nagara 北海道大学, 大学院・医学研究科, 教授 (30171888)
INUBUSHI Masayuki 放射線医学総合研究所, 分子イメージング研究センター, 研究員 (70399830)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 分子イメージング / 遺伝子イメージング / 低酸素 / PET / 頭頸部癌 / 化学療法 / 放射線治療 / 治療抵抗性 |
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| Research Abstract |
Establishment of genetic hypoxia imaging is very critical for the treatment of oral cancer. The expression of the human sodium-iodide symporter (hNIS) gene is visualized by positron emission tomography (PET) and single photon emission computed tomography (SPECT). Our group has already established cell lines stably expressing hNIS. We established the cancer cell line stably expressing hNIS (HCT116-hNIS line B), and succeeded in imaging the mouse xenograft model by 99mTcO4 SPECT. In the future, this model will provide a tool to track tumor metastasis in vivo in mice so that the molecular mechanism involved in metastatic cascade will be elucidated.
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