2009 Fiscal Year Final Research Report
Optimization of bone substitutes in dental field
| Project/Area Number |
19390513
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
KASUGAI Shohei Tokyo Medical and Dental University, 医歯学総合研究科, 教授 (70161049)
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| Co-Investigator(Kenkyū-buntansha) |
KONDO Hisatomo 東京医科歯科大学, 医歯学総合研究科, 助教 (70343150)
KURODA Shinji 東京医科歯科大学, 歯学部附属病院, 助教 (50323689)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 骨補填材 / ハイドロキシアパタイト / TCP / シンバスタチン |
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| Research Abstract |
Various calcium phosphate materials of different forms, which are resorbable or not resorbable, have been used as bone substitutes. However, autologous bone graft is still a gold standard for bone augmentation. Although bone substitutes, which are currently available, function as scaffold for bone regeneration and although they are osteo-conductive, they do not stimulate bone formation. The purpose of this project is to develop bone substitutes, which exchange to real bone stimulating bone formation. Firstly, we developed hydroxyapatite (HA) fiber material of 15μm diameter and demonstrated that this material exchanges to bone without inhibiting bone regeneration in animal experiments. Secondary, we developed the bone substitute by combining α-TCP, which is resorbable material, and simvastatin, which is an inhibitor of cholesterol synthesis. We observed that this bone substitute stimulates bone formation and exchanges to bone in animal experiments. Furthermore, efficacy and safety of this bone substitute were confirmed in clinical study. The two bone substitutes, which were developed in this project, would be potentially effective in dental field compared to the ones, which are clinically used.
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Research Products
(64 results)
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[Presentation] Novel GBR membrane consisting of cholesterol-bearing pullulan nanogel2010
Author(s)
Miyahara T, Nyan M, Nagayama T, Hao J, Rodoriguez R, Yamamoto Y, Shimoda A, Kuroda S, Tachikawa N, Shiota M, Akiyoshi K, Kasugai S
Organizer
The 25^<th> Annual Meeting of Academy of Osseointegration
Place of Presentation
Walt Disney World Dolphin Resort Hotel, Orland, USA
Year and Date
20100304-20100307
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[Presentation] Vertical bone augmentation by space creation2009
Author(s)
Nyan M, Miyahara T, Noritake K, Jia H, Rodriguez R, Kasugai S.
Organizer
2nd Meeting of IADR Pan Asian Pacific Federation (PAPF) and the 1st Meeting of IADR Asia/Pacific Region (APR)
Place of Presentation
Wuhan, China
Year and Date
20090922-20090924
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[Presentation] 超薄膜ハイドロキシアパタイト (HA) コーティングインプラントの臨床試験2007
Author(s)
春日井昇平, 越智守生, 塩田真, 廣瀬由紀人, 立川敬子, 國安宏哉, 近藤尚知, 松原秀樹, 黒田真司, 平博彦, 藤森達也, 村田勝, 北所弘行, 草野薫
Organizer
第37回日本口腔インプラント学会学術大会
Place of Presentation
熊本
Year and Date
20070914-20070916
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