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2009 Fiscal Year Final Research Report

Study of effect of oral microflora on oral and general health

Research Project

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Project/Area Number 19390541
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Social dentistry
Research InstitutionKyushu University

Principal Investigator

YAMASHITA Yoshihisa  Kyushu University, 大学院・歯学研究院, 教授 (20192403)

Co-Investigator(Kenkyū-buntansha) NAKANO Yoshio  九州大学, 大学院・歯学研究院, 准教授 (80253459)
SHIMAZAKI Yoshihiro  九州大学, 大学院・歯学研究院, 准教授 (10291519)
SHIOTA Susumiu  九州大学, 大学院・歯学研究院, 助教 (00150467)
KIYOHARA Yutaka  九州大学, 大学院・医学研究院, 教授 (80161602)
IIDA Mitsuo  九州大学, 大学院・医学研究院, 教授 (00127961)
Project Period (FY) 2007 – 2009
Keywords口腔フローラ / T-RFLP / 口腔疾患 / 全身の健康
Research Abstract

In this study, oral microflora was examined in relationship to periodontitis and malodor, and was further analyzed with febrile days and pneumonia in institutionalized elderly. To characterize the composition of oral microflora, chromosomal DNA was extracted from bacteria in saliva or tongue coat and Terminal-Restriction Fragment Length Polymorphism analysis was carried out using the extracted bacterial DNA as template. The results indicated that T-RFLP pattern of salivary bacteria was closely associated with the prevalence of periodontitis and malodor. In addition, T-RFLP pattern in tongue coat was also associated with febrile days and pneumonia in institutionalized elderly.

  • Research Products

    (23 results)

All 2010 2009 2008 2007 Other

All Journal Article (5 results) Presentation (15 results) Book (2 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Relationship between oral malordor and the global composition of indigenous bacterial populations in salaiva Appl Environ Microbiol.2010

    • Author(s)
      Takeshita T, Suzuki N, Nakano Y, Shimazaki Y, Yoneda M, Hirofqi T, Yamashita Y
    • Journal Title

      (in press)

  • [Journal Article] JAm Geriatr Soc2010

    • Author(s)
      Takeshita T, Tomioka M, Shimazaki Y, Matsuyama M, Koyano K, Matsuda K, Yamashita Y
    • Journal Title

      (in press)

  • [Journal Article] The ecological proportion of indigenous bacterial populations in saliva is correlated with oral health status.2009

    • Author(s)
      Takeshita T, Nakano Y, Kumagai T, Yasui M, Kamio N, Shibata Y, Shiota S, Yamashita Y
    • Journal Title

      ISMEJ 3(1)

      Pages: 65-78

  • [Journal Article] Development and application of a T-RFLP data analysis method using correlation coefficient matrices.2008

    • Author(s)
      Nakano Y, Takeshita T, Kamio N, Shiota S, Shibata Y, Yasui M, Yamashita Y
    • Journal Title

      JMicrobiol Methods 75(3)

      Pages: 501-505

  • [Journal Article] Improveded accuracy in terminal restriction fragment length polymorphism phylogenetic analysis using a novel internal size standarddefinition.2007

    • Author(s)
      Takeshita T, Nakano Y, Yamashita Y
    • Journal Title

      Oral Microbiol Immunol 22(6)

      Pages: 419-428

  • [Presentation] 唾液中に認められる細菌種の由来についての検討2010

    • Author(s)
      竹下徹、山中渉、山下喜久
    • Organizer
      第83回日本細菌学会総会
    • Place of Presentation
      横浜市
    • Year and Date
      2010-03-28
  • [Presentation] 口腔細菌叢と高齢者の健康2010

    • Author(s)
      山下喜久
    • Organizer
      第83回日本細菌学会総会ワークショップ
    • Place of Presentation
      横浜市
    • Year and Date
      2010-03-27
  • [Presentation] Relationship between the global composition of indigenous bacterial populations in saliva and oral malodor2010

    • Author(s)
      Takeshita T, Suzuki N, Nakano Y, Shimazakia Y, Yoneda M, Hirofuji T, Yamashita Y
    • Organizer
      International symposium on "oral health science" in 2010
    • Place of Presentation
      Fukuoka, Japan
    • Year and Date
      2010-02-06
  • [Presentation] 口腔細菌叢の総合解析に基づく未来型歯科口腔管理システムの構築2009

    • Author(s)
      山下喜久、中野善夫、廣藤卓雄、熊谷崇
    • Organizer
      第25回歯科医学を中心とした総合的な研究を推進する集い(平成20年度)
    • Place of Presentation
      東京
    • Year and Date
      20090100
  • [Presentation] 口腔フローラの構成の評価とその可能性2009

    • Author(s)
      竹下徹、山下喜久
    • Organizer
      第58回日本口腔衛生学会自由集会
    • Place of Presentation
      岐阜市
    • Year and Date
      2009-10-09
  • [Presentation] Comprehensive analysis of the bacterial flora of tongue coating and pneumonia risk in the institutionalized elderly2009

    • Author(s)
      Tomioka M, Takeshita T, Shimazaki Y, Matsuyama M, Koyano K, Yamashita Y
    • Organizer
      First European Congress on Microbial Biofilms
    • Place of Presentation
      Rome, Italia
    • Year and Date
      2009-09-05
  • [Presentation] 高齢者における摂食状況と口腔細菌構成との関連性について2009

    • Author(s)
      冨岡未記子、竹下徹、嶋崎義浩、山下喜久
    • Organizer
      第31回日本口腔衛生学会九州地方会
    • Place of Presentation
      北九州市
    • Year and Date
      2009-07-05
  • [Presentation] The change of microbial populations during plaque development2008

    • Author(s)
      Yasui M, Takeshita T, Nakano Y, Shimazaki Y, Shibata Y, Shiota S, AkifusaS, Yamashita Y
    • Organizer
      8th Congress of Asian Academy of Preventive Dentistry
    • Place of Presentation
      Cheju, Korea
    • Year and Date
      2008-11-06
  • [Presentation] Relationship between the tongue conditions and pyrexia in the elderly2008

    • Author(s)
      Tomioka M, Shimazaki Y, Takeshita T, MatsuyamaM, Koyano K, Yamashita Y
    • Organizer
      8th Congress of Asian Academy of Preventive Dentistry
    • Place of Presentation
      Cheju, Korea
    • Year and Date
      2008-11-06
  • [Presentation] 口腔フローラのバランスと口腔の健康状態との関連性2008

    • Author(s)
      竹下徹、中野善夫、安井雅樹、熊谷崇、山下喜久
    • Organizer
      第50回歯科基礎医学会学術大会サテライトシンポジウム
    • Place of Presentation
      札幌市
    • Year and Date
      2008-09-23
  • [Presentation] デンタルプラークの形成過程における細菌叢の変化について2008

    • Author(s)
      安井雅樹、中野善夫、柴田幸江、塩田進、秋房住郎、嶋崎義浩、竹下徹、山下喜久
    • Organizer
      第30回日本日腔衛生学会九州地方会
    • Place of Presentation
      大分市
    • Year and Date
      2008-07-05
  • [Presentation] Correlation between oral malodor and bacterial composition in saliva2008

    • Author(s)
      Takeshital T, Suzuki N, Nakano Y, YonedaM, Shibata Y, Shiota S, Kamio N, Hirofuji T, Yamashita Y
    • Organizer
      86th General Session & Exhibition of the IADR
    • Place of Presentation
      Toronto, Canada
    • Year and Date
      2008-07-03
  • [Presentation] サポートベクターマシンを用いた唾液細菌叢分析に基づく口臭推定法2008

    • Author(s)
      中野善夫、竹下徹、神尾宜昌、柴田幸江、塩田進、鈴木奈央、米田雅裕、廣藤卓雄、山下喜久
    • Organizer
      第81回日本細菌学会総会
    • Place of Presentation
      京都市
    • Year and Date
      2008-03-24
  • [Presentation] 相関行列を利用した多サンプルT-RFLP分析結果の「二次元」解析法2007

    • Author(s)
      中野善夫、竹下徹、山下喜久
    • Organizer
      第30回日本分子生物学会/第80回日本生化学会合同大会
    • Place of Presentation
      横浜市
    • Year and Date
      2007-12-13
  • [Presentation] 口腔フローラが健康に及ぼす影響の解明2007

    • Author(s)
      竹下徹、中野善夫、柴田幸江、塩田進、嶋崎義裕、鈴木奈央、米田雅裕、廣藤卓雄、山下喜久
    • Organizer
      第29回日本口腔衛生学会九州地方会
    • Place of Presentation
      福岡市
    • Year and Date
      2007-07-08
  • [Book] 新時代のプラークの病原性の評価2009

    • Author(s)
      山下喜久
    • Total Pages
      87-103
    • Publisher
      末永書店
  • [Book] A comprehensive evaluation of the virulence of oral flora

    • Author(s)
      Yamashita Y, Takeshita T
    • Total Pages
      251-267
    • Publisher
      Medical Information Science Reference, New York, USA
  • [Patent(Industrial Property Rights)] 歯周病リスクの評価方法2010

    • Inventor(s)
      藤中英剛、坂本考司、中村純二、山下喜久、竹下徹
    • Industrial Property Rights Holder
      花王株式会社、国立大学法人九州大学
    • Industrial Property Number
      特願2010-064709
    • Filing Date
      2010-03-19

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Published: 2011-06-18   Modified: 2016-04-21  

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