Development of preventive measures against systemic diseases caused by oral biofilm

2009 Fiscal Year Final Research Report

• Project/Area Number: 19390543
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Social dentistry
• Research Institution: Kagoshima University
• Principal Investigator: OHO Takahiko Kagoshima University, 大学院・医歯学総合研究科, 教授 (50160940)
• Co-Investigator(Kenkyū-buntansha): YAMAGUCHI Taihei 鹿児島大学, 大学院・医歯学総合研究科, 准教授 (80230358) ; KITADA Katsuhiro 鹿児島大学, 大学院・医歯学総合研究科, 助教 (90195264) ; NAGATA Emi 鹿児島大学, 医学部・歯学部附属病院, 助教 (00304816) ; YOSHIDA Yasuo 岩手医科大学, 歯学部, 准教授 (10315096) ; SATOU Setsuko 鹿児島大学, 医学部・歯学部附属病院, 講師 (70145514)
• Project Period (FY): 2007 – 2009
• Keywords: 歯学 / 微生物 / 感染症 / 歯垢

Research Abstract

Mechanisms of systemic diseases caused by oral biofilm were examined to develop new preventive methods against the diseases. Interaction between oral streptococci recovered from abscess lesion and salivary proteins was clarified. Human aortic endothelial cells were invaded by oral streptococci recovered from infective endocarditis and produced more inflammatory cytokines than non-invaded cells. Oral opportunistic bacteria recovered from pneumonia lesion showed capability to bind to saliva-coated endotracheal tubes and cuffs.

Research Products

• [Journal Article] Gene cloning and characterization of Streptococcus intermedius fimbriae involved in salivamediated aggregation and adherence. (2009)
  • Author(s): Yamaguchi, T., Matsumoto, M., Sugimoto, Y., Soutome, S., Oho, T.
  • Journal Title: Res. Microbiol. 160 Pages: 809-816
  • Peer Reviewed
• [Journal Article] Increase in detectable opportunistic bacteria in the oral cavity of orthodontic patients. (2009)
  • Author(s): Kitada, K., de Toledo, A., Oho, T.
  • Journal Title: Int. J. Dent. Hygiene 7 Pages: 121-125
  • Peer Reviewed
• [Journal Article] 口腔バイオフィルムによる全身疾患の誘発. (2009)
  • Author(s): 長田恵美, 於保孝彦
  • Journal Title: 日本歯科評論 795 Pages: 157-159
• [Journal Article] Molecular and Enzymatic Characterization of βC-S lyase in Streptococcus constellatus. (2008)
  • Author(s): Yoshida, Y., Ito, S., Sasaki, T., Kishi, M., Kurota, M., Suwabe, A., Kunimatsu, K., H. Kato
  • Journal Title: Oral Microbiol. Immunol. 23 Pages: 245-253
  • Peer Reviewed
• [Journal Article] Antibacterial activity of sodium fluoride against the Streptococcus anginosus group and Abiotrophia and Granulicatella species. (2007)
  • Author(s): Fukushima, R., Nagata, E., Inoue, M., Oho, T.
  • Journal Title: Dentistry in Japan 43 Pages: 95-98
  • Peer Reviewed
• [Presentation] 口腔レンサ球菌のヒト動脈内皮細胞への侵入能力および炎症反応誘導について (2009)
  • Author(s): 長田恵美, Toledo Andreia, 於保孝彦
  • Organizer: 第58回日本口腔衛生学会総会
  • Place of Presentation: 長良川国際会議場(岐阜)
  • Year and Date: 2009-10-11
• [Presentation] 口腔レンサ球菌のカルシウム依存性唾液凝集反応の解析 (2009)
  • Author(s): 山口泰平, 於保孝彦
  • Organizer: 第58回日本口腔衛生学会総会
  • Place of Presentation: 長良川国際会議場(岐阜)
  • Year and Date: 2009-10-11
• [Presentation] Streptococcus oralisのヒト動脈内皮細胞への侵入および炎症反応誘導におけるRPSの役割 (2009)
  • Author(s): Toledo Andreia, 長田恵美, 吉田康夫, 於保孝彦
  • Organizer: 第58回日本口腔衛生学会総会
  • Place of Presentation: 長良川国際会議場(岐阜)
  • Year and Date: 2009-10-10
• [Presentation] 唾液NADH oxidaseに関する研究 (2008)
  • Author(s): 佐藤節子, 於保孝彦
  • Organizer: 第57回日本口腔衛生学会総会
  • Place of Presentation: 大宮ソニックシティ(さいたま)
  • Year and Date: 2008-10-04
• [Presentation] Streptococcus mutansと唾液凝集素の反応を阻害するラクトフェリン・ドメイン (2008)
  • Author(s): 於保孝彦
  • Organizer: 第1回歯周病・ラクトフェリンフォーラム
  • Place of Presentation: 大宮ソニックシティ(さいたま)
  • Year and Date: 2008-04-27
• [Presentation] Streptococcus gordoniiのヒト動脈内皮細胞への侵入能力の検討 (2007)
  • Author(s): 長田恵美, 於保孝彦
  • Organizer: 第56回日本口腔衛生学会総会
  • Place of Presentation: 船堀タワー(東京)
  • Year and Date: 2007-10-05
• [Presentation] Granulicatella adiacens表層のフィブロネクチン結合物質の同定, 解析 (2007)
  • Author(s): 五月女さき子, 山口泰平, 於保孝彦
  • Organizer: 第56回日本口腔衛生学会総会
  • Place of Presentation: 船堀タワー(東京)
  • Year and Date: 2007-10-05