2009 Fiscal Year Final Research Report
Exploration of bioactive compounds from traditional medicinal plants in Vietnam
| Project/Area Number |
19406003
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
Environmental pharmacy
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| Research Institution | University of Tsukuba |
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Principal Investigator |
KANAHO Yasunori University of Tsukuba, 大学院・人間総合科学研究科, 教授 (00214437)
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| Co-Investigator(Kenkyū-buntansha) |
KUMAGAI Yoshito 筑波大学, 大学院・人間総合科学研究科, 教授 (00250100)
NAGATA Kyosuke 筑波大学, 大学院・人間総合科学研究科, 教授 (40180492)
OHNEDA Osamu 筑波大学, 大学院・人間総合科学研究科, 教授 (30311872)
KATO Mitsuyasu 筑波大学, 大学院・人間総合科学研究科, 教授 (20194855)
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| Project Period (FY) |
2007 – 2009
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| Keywords | ベトナム / Garcinia vilersiana / Nrf2 / Heme oxygenase-1 |
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| Research Abstract |
Garcinia vilersiana is medium size tree and commonly used for traditional medicinal purposes in Vietnam. In this study, we investigated the ability of Garcinia vilersiana extract to activate transcription factor Nrf2 in RAW264.7 cells. We found that Garcinia vilersiana bark extract activates Nrf2, leading to increase in antioxidant response element (ARE) binding activity and transcriptional activation of ARE. Garcinia vilersiana bark extract was also found to induce heme oxygenase-1 (HO-1) protein expression, suggesting that the drug action of Garcinia vilersiana may be attributable to activation of Nrf2-HO-1 signaling.
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[Journal Article] Pertussis toxin up-regulates angiotensin type 1 receptors through Toll-like receptor 4-mediated Rac activation2010
Author(s)
Nishida M., Suda R., Nagamatsu Y., Tanabe S., Onohara N., Nakaya M., Kanaho Y., Shibata T., Uchida K., Sumimoto H., Sato Y., Kurose H.
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Journal Title
J.Biol.Chem. 285
Pages: 15268-15277
Peer Reviewed
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[Journal Article] Sequential regulation of DOCK2 dynamics by two phospholipids during neutrophil chemotaxis2009
Author(s)
Nishikimi A., Fukuhara H., Su W., Hongu T., Takasuga S., Mihara H., Cao Q., Sanematsu F., Kanai M., Hasegawa H., Tanaka Y., Shibasaki M., Kanaho Y., Sasaki T., Frohman M. A., Fukui Y.
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Journal Title
Science 324
Pages: 384-387
Peer Reviewed
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[Journal Article] Loss of PIP5KIβ demonstrates that PIP5KI isoform-specific PIP_2 synthesis is required for IP_3 formation2008
Author(s)
Wang Y., Chen X., Lian L., Tang T., Stalker TJ., Sasaki T., Kanaho Y., Brass LF., Choi J. K., Hartwig J. H., Abrams C. S.
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Journal Title
Proc.Natl.Acad.Sci.USA 105
Pages: 14064-16069
Peer Reviewed
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[Journal Article] Loss of PIP5KIγ, unlike other PIP5KI isoforms, impairs the integrity of the membrane cytoskeleton in murine megakaryocytes2008
Author(s)
Wang Y., Litvinov RI., Chen X., Bach TL., Lian L., Petrich B. G., Monkley S. J., Kanaho Y., Critchley D. R., Sasaki T., Birnbaum M. J., Weisel J. W., Hartwig J., Abrams C. S.
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Journal Title
J.Clin.Invest. 118
Pages: 812-819
Peer Reviewed
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[Journal Article] Control of cell polarity and motility by the PtdIns (3, 4, 5) P (3) phosphatase SHIP12007
Author(s)
Nishio M., Watanabe K., Sasaki J., Taya C., Takasuga S., Iizuka R., Balla T., Yamazaki M., Watanabe H., Itoh R., Kuroda S., Horie Y., Forster I., Mak T.S., Yonekawa H., Penninger J. M., Kanaho Y., Suzuki A., Sasaki T.
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Journal Title
Nat.Cell Biol. 9
Pages: 36-44
Peer Reviewed
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[Presentation]2009
Author(s)
T. Hongu, Y. Funakoshi, H. Hasegawa, Y. Kanaho
Organizer
Involvement of small GTPase Arf6 in angiogenesis
Place of Presentation
筑波
Year and Date
20091118-20091119
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