2010 Fiscal Year Final Research Report
Molecular epidemiology using new diagnostic methods, therapy and prevention for pediatric viral infection in Asia
| Project/Area Number |
19406026
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
Pediatrics
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| Research Institution | Aino University (2008-2010)
The International University of Kagoshima (2007) |
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Principal Investigator |
USHIJIMA Hiroshi Aino University, 医療保健学部, 特任教授 (10091068)
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| Co-Investigator(Renkei-kenkyūsha) |
OKITSU Shoko 東京大学, 医学系研究科, 客員研究員 (10082215)
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| Project Period (FY) |
2007 – 2010
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| Keywords | ウイルス感染 / 小児 / アジア / 診断法 |
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| Research Abstract |
Molecular epidemiological studies of HIV, rubella virus, 11 types of diarrheal viruses and 7 types of respiratory viruses were conducted in children in Asia. Overall, the results of the molecular epidemiological studies in Asia were similar to those in Japan. It was interesting to find that the reassortant strains of viruses among human and animal were observed in Asia. Moreover, we also discovered the new strains of the viruses. Our studies demonstrated that pigs, calves and environmental contaminations were served as the original sources for virus infection to human. This issue rises the important concerning of zoonosis infection. Our epidemic survey study of rubella virus also suggested that the rubella vaccine is necessary in developing countries.
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[Journal Article] Detection and genetic characterization of rotavirus infections in non-hospitalized children with acute gastroenteritis in Japan, 2007-2009.2011
Author(s)
Chan-it W, Thongprachum A, Dey SK, Phan TG, Khamrin P, Okitsu S, Nishimura S, Kobayashi M, Kikuta H, Baba T, Yamamoto A, Sugita K, Hashira S, Tajima T, Ishida S, Mizuguchi M, Ushijima H
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Journal Title
Infect Genet Evol 11
Pages: 415-422
Peer Reviewed
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[Journal Article] Human parechovirus infection in children hospitalized with acute gastroenteritis in Sri Lanka.2011
Author(s)
Pham NTK, Takanashi S, Tran DN, Trinh DQ, Abeysekera C, Abeygunawardene A, Khamrin P, Okitsu S, Shimizu H, Mizuguchi M, Ushijima H
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Journal Title
J Clin Microbiol 49
Pages: 364-366
Peer Reviewed
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[Journal Article] Genotypic linkage of VP4, VP6, VP7, NSP4, NSP5 genes of rotaviruses circulating among children with acute gastroenteritis in Thailand.2010
Author(s)
Khamrin P, Maneekarn N, Malasao R, Nguyen TA, Ishida S, Okitsu S, Ushijima H
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Journal Title
Infect Genet Evol 10
Pages: 467-472
Peer Reviewed
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[Journal Article] Characterization of broad reactive monoclonal antibody against Norovirus genogroup I and II : Recognition of a novel conformational epitope.2007
Author(s)
Shiota T, Okame M, Takanashi S, Khamrin P, Takagi M, Satou K, Masuoka Y, Yagyu F, Shimizu Y, Kohno H, Mizuguchi M, Okitsu S, Ushijima H
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Journal Title
J Virol 81
Pages: 12298-1230
Peer Reviewed
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