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2009 Fiscal Year Final Research Report

Investigation of disease susceptibility genes associated with intractable intraocular inflammation with racial differences and development of new antioxidant therapy

Research Project

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Project/Area Number 19406028
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Ophthalmology
Research InstitutionHokkaido University

Principal Investigator

OHNO Shigeaki  Hokkaido University, 大学院・医学研究科, 特任教授 (50002382)

Co-Investigator(Kenkyū-buntansha) ISHIDA Susumu  北海道大学, 大学院・医学研究科, 教授 (10245558)
YOSHIDA Kazuhiko  北海道大学, 大学病院, 講師 (90281807)
NAMBA Kenichi  北海道大学, 大学病院, 助教 (70333599)
KITAICHI Nobuyoshi  北海道大学, 大学病院, 助教 (40431366)
TAGAWA Yoshitsugu  北海道大学, 大学院・医学研究科, 准教授 (40109426)
ONOE Kazunori  北海道大学, 遺伝子病制御研究所, 教授 (40002117)
Co-Investigator(Renkei-kenkyūsha) MIZUKI Nobuhisa  横浜市立大学, 医学部, 教授 (90336579)
INOKO Hidetoshi  東海大学, 医学部, 教授 (10101932)
Project Period (FY) 2007 – 2009
Keywords疾患感受性遺伝子 / ベーチェット病 / 難治性内眼炎 / アデノウイルス角結膜炎 / 分子疫学
Research Abstract

In GWAS studies in Behcet disease, 2 new genes and HLA-B*510101 were found. In Vogt-Koyanagi-Harada disease, HLA-DRB1*0405 and several genetic associations were also found. Virological studies revealed 2 new human adenoviruses (HAdV 53 and 54). One of the carotenoids, astaxanthin showed significant increase of choroidal blood flow. DHMEQ, a new NF-κB blocker also showed significant suppression of experimental uveoretinitis.

  • Research Products

    (25 results)

All 2009 2008 2007

All Journal Article (17 results) (of which Peer Reviewed: 17 results) Presentation (8 results)

  • [Journal Article] Lack of association between toll-like receptor 4 gene polymorphisms and sarcoidosis-related uveitis in Japan2009

    • Author(s)
      Asukata Y, Ota M, Meguro A, Katsuyama Y, Ishihara M, Namba K, Kitaichi N, Morimoto S, Kaburaki T, Ando Y, Takenaka S, Inoko H, Ohno S, Mizuki N
    • Journal Title

      Mol Vis VOL. 15

      Pages: 14-20

    • Peer Reviewed
  • [Journal Article] Evaluation of PTPN22 polymorphisms and Vogt-Koyanagi-Harada disease in Japanese patients2009

    • Author(s)
      Horie Y, Kitaichi N, Katsuyama Y, Yoshida K, Miura T, Ota M, Asukata Y, Inoko H, Mizuki N, Ishida S, Ohno S
    • Journal Title

      Mol Vis VOL. 15

      Pages: 1115-1119

    • Peer Reviewed
  • [Journal Article] Association of TLR4 polymorphisms with Behcet's disease in a Korean population2009

    • Author(s)
      Horie Y, Neguro A Ota M, Kitaichi N, Katsuyama Y, Takemoto Y, Namba K, Yoshida K, Song Y W, ParkK S, Lee E B, Inoko H, Mizuki N, Ohno S
    • Journal Title

      Rheumatology VOL. 48

      Pages: 638-642

    • Peer Reviewed
  • [Journal Article] Investigation of the association between the GLC3A locus andnormal tension glaucoma in Japanese patients by microsatellite analysis2009

    • Author(s)
      Kamio M, Meguro A, Ota M, Nomura N, Kashiwagi K, Mabuchi F, Iijima H, Kawase K, Yamamoto T, Nakamura M, Negi A, Sagara T, Nishida T, Inatani M, Tanihara H, Aihara M, Araie M, Fukuchi T, Abe H, Higashide T, Sugiyama K, Kanamoto T, Kiuchi Y, Iwase A, Ohno S,Inoko H, Mizuki N
    • Journal Title

      Clin Ophthalmol VOL. 3

      Pages: 183-188

    • Peer Reviewed
  • [Journal Article] Proliferative diabetic retinopathy with lymphocyte-rich epiretinal membrane associated with poor visual prognosis2009

    • Author(s)
      Kase S, Saito W, Ohno S, Ishida S
    • Journal Title

      Invest Ophthalmol Vis Sci VOL. 50

      Pages: 5909-5912

    • Peer Reviewed
  • [Journal Article] Low prevalence of juvenile-onset Behcet's diease with uveitis in east/south Asian people2009

    • Author(s)
      Kitaichi N, Miyazaki A, Stanford MR, Iwata D, Chams H, Ohno S
    • Journal Title

      Br J Ophthalmol VOL. 93

      Pages: 1428-1430

    • Peer Reviewed
  • [Journal Article] Clinical features of intraocular inflammation in Hokkaido, Japan2009

    • Author(s)
      Kitamei H, Kitaichi N, Namba K, Kotake S, Goda C, Kitamura M, Miyazaki A, Ohno S
    • Journal Title

      Acta Ophthalmol VOL. 87

      Pages: 424-428

    • Peer Reviewed
  • [Journal Article] Association of microsatellite polymorphisms of the GPDS1 locus with normal tension glaucoma in the Japanese population2009

    • Author(s)
      Nakamura K, Ota M, Meguro A, Nomura N, Kashiwagi K, Mabuchi F, Iijima H, Kawase K, Yamamoto T, Nakamura M,Negi A, Sagara T, Nishida T, Inatani M, Tanihara H, Aihara M, Araie M, Fukuchi T, Abe H Higashide T, Sugiyama K, Kanamoto T, Kiuchi Y, Iwase A, Ohno S, Inoko H, Mizuki N
    • Journal Title

      Clin Ophthalmol VOL. 3

      Pages: 307-312

    • Peer Reviewed
  • [Journal Article] New susceptibility locus for high myopia is linked to the uromodulin-like 1 (UMODL1) gene region on chromosome 21q22.32009

    • Author(s)
      Nishizaki R, Ota M, Inoko H, Meguro A, Shiota T, Okada E, Mok J, Oka A, Ohno S, Mizuki N
    • Journal Title

      Eye VOL. 23

      Pages: 222-229

    • Peer Reviewed
  • [Journal Article] Investigation of the association between toll-like receptor 2 gene polymorphisms and Behcet's disease in Japanese patients2009

    • Author(s)
      Tomiyama R, Meguro A, Ota M, Katsuyama Y, Nishide T, Uemoto R, Iijima Y, Ohno S, Inoko H, Mizuki N
    • Journal Title

      VOL. 70

      Pages: 41-44

    • Peer Reviewed
  • [Journal Article] Anti-inflammatory effect of angiotensin type 1 receptor antagonist on endotoxin-induced uveitis in rats2008

    • Author(s)
      Miyazaki A, Kitaichi N, OhgamiK, Iwata D, Jin XH, Iwabuchi K, Morohashi T, Ohno S, Onoe K
    • Journal Title

      Graefes Arch Clin Exp Ophthalmol VOL. 246

      Pages: 747-757

    • Peer Reviewed
  • [Journal Article] Guidelines for the diagnosis of ocular sarcoidosis2008

    • Author(s)
      Asukata Y, Ishihara M, Hasumi Y, Nakamura S, Hayashi K, Ohno S, Mizuki N
    • Journal Title

      Ocul Immunol Inflamm VOL. 16

      Pages: 77-81

    • Peer Reviewed
  • [Journal Article] Sister cases of Behcet's disease and Vogt-Koyanagi-Harada disease2008

    • Author(s)
      Horie Y, Namba K, Kitaichi N, Ohno S
    • Journal Title

      Br J Ophthalmol VOL. 92

      Pages: 433-434

    • Peer Reviewed
  • [Journal Article] Evaluation of mixed infection cases with both herpes simplex virus types 1 and 22008

    • Author(s)
      Kaneko H, Kawana T, Ishioka K, Ohno S, Aoki K, Suzutani T
    • Journal Title

      J Med Virology VOL. 80

      Pages: 883-887

    • Peer Reviewed
  • [Journal Article] Polymorphism of IFN-gamma gene and Vogt-Koyanagi-Harada disease2008

    • Author(s)
      Horie Y, Kitaichi N, Takemoto Y, Namba K, Yoshida K, Hirose S, Hasumi Y, Ota M, Inoko H, Mizuki N, Ohno S
    • Journal Title

      Mol Vis VOL. 92

      Pages: 2334-2338

    • Peer Reviewed
  • [Journal Article] Primary central nervous system lymphoma with intraocular recurrence after optic nerve disorder2007

    • Author(s)
      Horie Y, Saito W, Kase S, Yoshida K, Ohno S
    • Journal Title

      Retinal Cases & Brief Reports VOL. 1

      Pages: 165-168

    • Peer Reviewed
  • [Journal Article] Lack of Association of Toll-like receptor 9 gene polymorphism with Behcet's disease in Japanese patients2007

    • Author(s)
      Ito A, Ota M, Katsuyama Y, Inoko H, Ohno S, Mizuki N
    • Journal Title

      Tissue Antigens VOL. 70

      Pages: 423-426

    • Peer Reviewed
  • [Presentation] Ocular Inflammatory Disease : Clinical pictures of sarcoidosis2009

    • Author(s)
      Ohno S.
    • Organizer
      The 12th Seoul National University-Hokkaido University Joint Symposium
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2009-11-19
  • [Presentation] Clinical features of intraocular inflammation in Asia-Pacific region2009

    • Author(s)
      Ohno S, Namba K, Kitaichi N, Ishida S.
    • Organizer
      The 4th Congress of the Asia-Pacific Vitreo-Retinal Society
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2009-11-12
  • [Presentation] Intraocular inflammation in Asia2009

    • Author(s)
      Ohno S, Kitaichi N, Namba K.
    • Organizer
      The 2nd International Uveitis/The 3rd Asia Pacific Intraocular Inflammation/The 8th Chinese Ocular Immunology Combined Symposium
    • Place of Presentation
      Chongqing, China
    • Year and Date
      2009-11-06
  • [Presentation] Young Investigator Award Lecture : Low prevalence of juvenile-onset Behcet's disease with uveitis in east/south Asian people2009

    • Author(s)
      Kitaichi N, Ohno S.
    • Organizer
      The 2nd International Uveitis Symposium/The 3rd Asia-Pacific Intraocular Inflammation Symposium/The 8th Chinese Ocular Immunology Symposium
    • Place of Presentation
      Chongqing, China
    • Year and Date
      2009-11-06
  • [Presentation] Clinical features of Behcet's disease2009

    • Author(s)
      Ohno S, Lennikov A
    • Organizer
      Meeting in Research Institution of Rheumatology Diseases
    • Place of Presentation
      Moscow, Russia
    • Year and Date
      2009-09-15
  • [Presentation] Vogt-Koyanagi-Harada disease2009

    • Author(s)
      Ohno S.
    • Organizer
      SOE 2009 : The 17th Congress of the European Society of Ophthalmology
    • Place of Presentation
      Amsterdam, The Netherlands
    • Year and Date
      2009-06-13
  • [Presentation] Early systemic corticosteroid therapy may reduce ocular complications in Vogt-Koyanagi-Harada disease2009

    • Author(s)
      Ohno S, Hirose S, Kitaichi N.
    • Organizer
      The 6th International Workshop on Vogt-Koyanagi-Harada disease & sympathetic ophthalmia/The 2nd International workshop on Sarcoidosis
    • Place of Presentation
      Singapore, Singapore
    • Year and Date
      2009-02-28
  • [Presentation] Diagnosis of Vogt-Koyanagi-Harada disease2009

    • Author(s)
      Ohno S, Kitaichi N.
    • Organizer
      The 6th International Workshop on Vogt-Koyanagi-Harada disease & sympathetic ophthalmia/The 2nd International workshop on Sarcoidosis
    • Place of Presentation
      Singapore, Singapore
    • Year and Date
      2009-02-27

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Published: 2011-06-18   Modified: 2016-04-21  

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