2009 Fiscal Year Final Research Report
Molecular and cellular mechanisms of ocular dominance plasticity in adult induced by serine proteases
| Project/Area Number |
19500285
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neuroscience in general
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
MATAGA Nobuko The Institute of Physical and Chemical Research, 生体物質分析支援ユニット, 支援ユニットリーダー (20209464)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 眼優位可塑性 / 臨界期 / 興奮性入力 / スパイン / セリンプロテアーゼ / テレンセファリン / 酵素消化 |
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| Research Abstract |
To understand the molecular and cellular mechanisms of ocular dominance (OD) plasticity in adulthood, we explored candidate substrates of serine proteases, which are essential for morphological plasticity. Using mice during and after the CP for OD plasticity, we found proteolysis of extracellular matrix proteins and adhesion molecules including telencephalin (TLCN) by plasmin. Interestingly, telencephalin slowed spine maturation while plasmin enhanced synaptic formation, suggesting that there is a negative correlation between the full-length TLCN and plasmin.
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