2009 Fiscal Year Final Research Report
Analysis of neural circuits in reward-related behaviors
| Project/Area Number |
19500297
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
KAI Nobuyuki Fukushima Medical University, 医学部, 助教 (50301750)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 側坐核 / 報酬行動 / ドパミン受容体 / イムノトキシン細胞標的法 / 神経回路網 |
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| Research Abstract |
Drug addiction is a terrible social problem. To understand which neural circuits are involved in the addiction, mutant mice in which a specific kind of neurons was removed were tested for drug-associated behavior. It was revealed that the loss of a kind of neurons in the Nucleus accumbens shell strengthened drug addiction. Deletion of another kind of neurons in the shell weakened drug addiction.
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