2009 Fiscal Year Final Research Report
Synaptic distribution of dopaminergic inputs to the prefrontal cortex related to working memory
| Project/Area Number |
19500300
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Toho University |
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Principal Investigator |
KURODA Masaru Toho University, 医学部, 教授 (10170135)
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| Co-Investigator(Kenkyū-buntansha) |
ODA Satoko 東邦大学, 医学部, 講師 (90224237)
YOKOFUJITA Junko 東邦大学, 医学部, 助教 (80114792)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 前頭前野 / 視床背内側核 / ドーパミン受容体 / 共焦点顕微鏡 / 興奮性ニューロン / 抑制性ニューロン / シナプス |
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| Research Abstract |
In this study, to identify the precise localization of dopamine receptor D5 (D5R) in the rat prefrontal cortex, we observed the D5R-immunolabeled structures by confocal laser microscopy. As a result, we found that nearly all neurons, both excitatory and inhibitory neurons, contained D5R, and that the intracellular distribution pattern of D5R is markedly different between them. These findings strongly suggested that the differential distribution pattern of D5R may underlie dopaminergic modulation of cognitive functions subserved by the prefrontal cortex.
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