2010 Fiscal Year Final Research Report
Development and valuation of anti-Alzheimer's drugs using molecular imaging
| Project/Area Number |
19500307
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Tohoku University |
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Principal Investigator |
FURUKAWA Atsutoshi Tohoku University, 病院, 准教授 (30241631)
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| Project Period (FY) |
2007 – 2010
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| Keywords | アルツハイマー病 / PET / アミロイド |
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| Research Abstract |
We recently developed a novel PET tracer, ^<11>C-BF227, and had success with in vivo detection of amyloid plaques in Alzheimer's disease (AD) brains. We applied this tracer to subjects with mild cognitive impairment (MCI) and AD in order to elucidate the status of amyloid plaque deposition in MCI and compared the effects of several drugs. AD patients showed increased uptake of ^<11>C-BF227 in the neocortical areas and striatum as well as decreased glucose metabolism in temporoparietal, posterior cingulate and medial temporal areas. MCI subjects showed a significant increase in BF-227 uptake in the neocortical areas similar to AD. BF227 uptake negatively correlated with glucose metabolism. Receiver operating characteristic (ROC) analysis indicated higher specificity and sensitivity with BF227-PET than those with FDG-PET for differential diagnosis between AD and normal control. We conclude that ^<11>C-BF227-PET has a possibility to be a useful technology for early detection of AD pathology and also even in the MCI stage.
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