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2009 Fiscal Year Final Research Report

Effects of fatty acids on differentiation of neuronal stem cells and the protective and ameliorative effects on dementia.

Research Project

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Project/Area Number 19500324
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurochemistry/Neuropharmacology
Research InstitutionShimane University

Principal Investigator

HASHIMOTO Michio  Shimane University, 医学部, 准教授 (70112133)

Co-Investigator(Kenkyū-buntansha) KATAKURA Masanori  島根大学, 医学部, 助教 (40383179)
Co-Investigator(Renkei-kenkyūsha) YAMASHITA Kazuya  島根県立大学, 短期大学部, 教授 (30210412)
Project Period (FY) 2007 – 2009
Keywords精神・神経疾患の病態と治療 / 神経幹細胞 / n-3系多価不飽和脂肪酸 / 神経新生 / ヒト介入試験
Research Abstract

1) Docosahexaenoic acid (DHA) and eicosapentaenoic acid, n-3 polyunsaturated fatty acids, promoted neurogenesis of neuronal stem cells (NSCs) isolated from rat embryos and also adult hippocampus. These n-3 fatty acids induce differentiation by causing cell cycle arrest in NSCs.
2) In randomized, double-blind and placebo-controlled trail, preventive effect of DHA supplement for 12 months on cognitive decline rate in elderly people with very mild dementia was observed.

  • Research Products

    (42 results)

All 2010 2009 2008 2007 Other

All Journal Article (10 results) (of which Peer Reviewed: 10 results) Presentation (23 results) Book (1 results) Remarks (8 results)

  • [Journal Article] Docosahexaenoic acid withstands the Aβ25-35-induced neurotoxicity in SH-S5Y5 cells2010

    • Author(s)
      Michio Hashimoto, Masanori Katakura, Shahdat Hossain, Azizur Rahman, Toshio Shimada, Osamu Shido
    • Journal Title

      Journal of Nutrition Biochemistry (in press)

    • Peer Reviewed
  • [Journal Article] Effects of docosahexaenoic acid on in vitro amyloid βpeptide 25-35 fibrillation.2009

    • Author(s)
      Michio Hashimoto, Hossain Md Shahdat, Masanori Katakura, YokoTanabe, Shuji Gamoh, Koji Miwa, Toshio Shimada, Osamu Shido.
    • Journal Title

      Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids. 1791

      Pages: 289-296

    • Peer Reviewed
  • [Journal Article] Docosahexaenoic acid promotes neuronal differentiation by regulating basic helix-loop-helix transcription factors and cell cycle in neural stem cells2009

    • Author(s)
      Masanori Katakura, Michio Hashimoto, Hossain Md Shahdat, Shuji Gamoh, Toshiyuki Okui, Kentaro Matsuzaki, Osamu Shido
    • Journal Title

      Neuroscience 160

      Pages: 651-60

    • Peer Reviewed
  • [Journal Article] Mechanism of docosahexaenoic acid-induced inhibition of in vitro amyloid β1-42 fibrillation and amyloid β1-42-induced toxicity in SH-S5Y5 cells.2009

    • Author(s)
      Shahdat Hossain, Michio Hashimoto, Masanori Katakura, Koji Miwa, Toshio Shimada, Osamu Shido.
    • Journal Title

      Journal of Neurochemistry 111

      Pages: 568-579

    • Peer Reviewed
  • [Journal Article] The protective effect of dietary eicosapentaenoic acid on the impairment of spatial cognition learning ability in rats infused with amyloid β(1-40).2009

    • Author(s)
      Michio Hashimoto, Shahdat Hossain, Yoko Tanabe, Akiko Kawashima, Tsuyoshi Harada, Takashi Yano, Kiyoshi Mizuguchi, Osamu Shido.
    • Journal Title

      Journal of Nutritional Biochemistry 20

      Pages: 965-973

    • Peer Reviewed
  • [Journal Article] 多価不飽和脂肪酸と疾患2中枢神経系2009

    • Author(s)
      橋本道男
    • Journal Title

      治療学 43

      Pages: 838-844

    • Peer Reviewed
  • [Journal Article] DHA disrupts in vitro amyloid β1-40 fibrillation and concomitantly inhibits amyloid levels in cerebral cortex tissue of Alzheimer's disease model rats.2008

    • Author(s)
      Michio Hashimoto, Hossain Md Shahdat, Shinji Yamashita, Masanori Katakura, Yoko Tanabe, Hironori Fujiwara, Shuji Gamoh, Teruo Miyazawa, Noriyuki Arai, Toshio Shimada, Osamu Shido.
    • Journal Title

      Journal of Neurochemistry 107

      Pages: 1634-1646

    • Peer Reviewed
  • [Journal Article] 食事で防ぐ認知症2008

    • Author(s)
      橋本道男、山下一也
    • Journal Title

      最新精神医学 13

      Pages: 75-82

    • Peer Reviewed
  • [Journal Article] ω3多価不飽和脂肪酸と中枢神経疾患2008

    • Author(s)
      橋本道男、蒲生修治、片倉賢紀、Hossain Shahdat
    • Journal Title

      The Lipid 19(4)

      Pages: 409-419

    • Peer Reviewed
  • [Journal Article] アルツハイマー病と食事栄養-とくに銅・亜鉛とドコサヘキサエン酸2008

    • Author(s)
      橋本道男
    • Journal Title

      Trace Nutrients Research 25

      Pages: 8-18

    • Peer Reviewed
  • [Presentation] n-3系脂肪酸によるアルツハイマー型認知症予防・改善効果2010

    • Author(s)
      橋本道男、ホサイン・シャハダト、片倉賢紀
    • Organizer
      第83回日本薬理学会年会シンポジウム
    • Place of Presentation
      大阪
    • Year and Date
      2010-03-17
  • [Presentation] ドコサヘキサエン酸(dha)と認知・記憶機能-認知症への介入試験の科学的根拠と作用メカニズム2010

    • Author(s)
      橋本道男、ホサイン・シャハダト、片倉賢紀
    • Organizer
      第13回日本病態栄養学会年次学術集会ワークショップ
    • Place of Presentation
      京都
    • Year and Date
      2010-01-10
  • [Presentation] Effect of polyunsaturated fatty acids on the cell cycle and the expression of bHLH transcriptional factors in neural stem cells.2009

    • Author(s)
      Masanori Katakura, Michio Hashimoto, Shuji Gamoh, Toshiyuki Okui, Kentaro Matsuzaki, Osamu Shido.
    • Organizer
      The 36th Congress of the International Union of Physiological Sciences
    • Place of Presentation
      Kyoto
    • Year and Date
      20090727-20090801
  • [Presentation] Docosahexaenoic acid improves behavioral impairment in amyloidβ(Aβ)-infused rats, by decreasing both in vitro and Aβlevels in the brain.2009

    • Author(s)
      Michio Hashimoto, Hossain Md Shahdat, Masanori Katakura, Yoko Tanabe, Toshio Shimada, Osamu Shido.
    • Organizer
      The 36th Congress of the International Union of Physiological Sciences
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      20090727-20090801
  • [Presentation] Inhibiting effect of docosahexaenoic acid on the amyloid beta peptide fibrillation.2009

    • Author(s)
      Michio Hashimoto, Hossain Md. Shahdat, Masanori Katakura, Osamu Shido.
    • Organizer
      2009 International Conference on Alzheimer's Disease (ICAD)
    • Place of Presentation
      Vienna, Austria
    • Year and Date
      20090711-20090716
  • [Presentation] Docosahexaenoic acid attenuates in vitro Aβfibrillation with concomitant decreases of Aβpeptide levels in brain of AD model rats.2009

    • Author(s)
      Michio Hashimoto, Hossain Md Shahdat, Masanori Katakura, Yoko Tanabe, Shuji Gamoh, Osamu Shido.
    • Organizer
      9th International Conference AD/PD 2009
    • Place of Presentation
      Praque, Czech Republic
    • Year and Date
      20090311-20090315
  • [Presentation] 脳機能賦活物質としてのドコサヘキサエン酸の魅力―島根疫学研究と基礎実験データから2009

    • Author(s)
      橋本道男
    • Organizer
      第8回ホスファチジルセリン研究会
    • Place of Presentation
      東京
    • Year and Date
      2009-11-20
  • [Presentation] DHAによる脳・神経機能の維持2009

    • Author(s)
      橋本道男
    • Organizer
      DHA・EPA協議会主催第11回公開講演会「DHA・EPAによる疾病予防」
    • Place of Presentation
      東京
    • Year and Date
      2009-10-27
  • [Presentation] Docosahexaenoic acid controls the expression of Hes1 and p27 on the neural stem cell differentiation神経幹細胞におけるHes1とp27発現量のドコサヘキサエン酸による調節2009

    • Author(s)
      Masanori Katakura, Michio Hashimoto, Hossain M Shahdat, Shuji Gamoh, Toshiyuki Okui, Osamu Shido
    • Organizer
      第32回日本神経科学会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-09-16
  • [Presentation] 神経幹細胞のニューロン分化に及ぼす9-cis, 11-trans-共役リノール酸の影響2009

    • Author(s)
      奥井俊之、橋本道男、片倉賢紀、紫藤治
    • Organizer
      日本脂質栄養学会第18回大会
    • Place of Presentation
      東京
    • Year and Date
      2009-09-04
  • [Presentation] 神経幹細胞のニューロンへの分化にともなうHes1とp27の発現量の変化に及ぼすドコサヘキサエン酸の影響2009

    • Author(s)
      片倉賢紀、橋本道男、奥井俊之、紫藤治
    • Organizer
      日本脂質栄養学会第18回大会
    • Place of Presentation
      東京
    • Year and Date
      2009-09-04
  • [Presentation] 食事で防ぐ認知症2008

    • Author(s)
      橋本道男
    • Organizer
      日本食品保蔵科学会第57大会市民セミナー
    • Place of Presentation
      松江市
    • Year and Date
      20080621-20080622
  • [Presentation] 多価不飽和脂肪酸による神経幹細胞の増殖・分化の変化2008

    • Author(s)
      片倉賢紀、橋本道男、蒲生修治、奥井俊之、紫藤治
    • Organizer
      第85回日本生理学会大会
    • Place of Presentation
      東京
    • Year and Date
      20080325-20080327
  • [Presentation] ドコサヘキサエン酸(DHA)と脳機能-基礎研究から臨床応用に向けて2008

    • Author(s)
      橋本道男
    • Organizer
      日本脂質栄養学会第17回大会サテライトシンポジウム「脳機能・行動・神経症に影響を与える脂質栄養」
    • Place of Presentation
      大阪
    • Year and Date
      2008-09-07
  • [Presentation] The role of docosahexaenoic acid for the constitution, function and maintenance of central nervous system.2008

    • Author(s)
      Shahdat Hossain, Shuji Gamoh, Masanori Katakura, Michio Hashimoto.
    • Organizer
      第31回日本神経科学会大会シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2008-07-09
  • [Presentation] 魚油成分(DHA・EPA)による認知症予防・改善効果2008

    • Author(s)
      橋本道男
    • Organizer
      第25回日本微量栄養素学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2008-05-30
  • [Presentation] 認知症と食事栄養2008

    • Author(s)
      橋本道男
    • Organizer
      第3回山陰高齢医学研究会
    • Place of Presentation
      松江
    • Year and Date
      2008-04-25
  • [Presentation] DHAによる認知症の改善2007

    • Author(s)
      橋本道男
    • Organizer
      第8回全国エゴマサミット
    • Place of Presentation
      庄原
    • Year and Date
      20070523-20070524
  • [Presentation] FISH OIL CONSUMPTION AND COGNITIVE FUNCTION IN ELDERLY PEOPLE: FROM SHIMANE COHORT STUSY IN JAPAN.2007

    • Author(s)
      Michio Hashimoto, Kazuya Yamashita, Masanori Katakura, Yuri Iyama, Ichie Matsumoto, Ayako Matsuoka, Osamu Shido, Setsushi Kato, Akira Ueki.
    • Organizer
      8th International Conference AD/PD 2007
    • Place of Presentation
      Salzburg, Austria
    • Year and Date
      20070314-20070318
  • [Presentation] MECHANISMS OF DIETARY DOCOSAHEXAENOIC ACID-INDUCED PROTECTION AND AMELIORATION ON IMPAIRMENT OF MEMORY LEARNING IN ALZHEIMER'S DISEASE MODEL RATS.2007

    • Author(s)
      Michio Hashimoto, Hossain Md Shahdat, Shinji Yamashita, Masanori Katakura, Yoko Tanabe, Hironori Fujiwara, Shuji Gamoh, Teruo Miyazawa, Noriyuki Arai, Osamu Shido.
    • Organizer
      8th International Conference AD/PD 2007
    • Place of Presentation
      Salzburg, Austria
    • Year and Date
      20070314-20070318
  • [Presentation] PROMOTION OF NEUROGENESIS BY DOCOSAHEXAENOIC ACID IN VIVO AND IN VITRO.2007

    • Author(s)
      Michio Hashimoto, Masanori Katakura, Eisuke Kawakita, Toshiyuki Okui, Shuji Gamoh, Haque Md Abdul, Budbazar Enkhjargal, Osamu Shido.
    • Organizer
      8th International Conference AD/PD 2007
    • Place of Presentation
      Salzburg, Austria
    • Year and Date
      20070314-20070318
  • [Presentation] n-3系脂肪酸、特にドコサヘキサエン酸による脳機能改善作用と認知症予防・改善効果2007

    • Author(s)
      橋本道男
    • Organizer
      日本脂質栄養学会第16回大会シンポジウム
    • Place of Presentation
      出雲市
    • Year and Date
      2007-08-31
  • [Presentation] n-3系脂肪酸と認知症2007

    • Author(s)
      橋本道男、片倉賢紀、田邊洋子、ホサイン・シャハダト、蒲生修治、宮澤陽夫、荒井啓行、紫藤治
    • Organizer
      第80回日本薬理学会年会シンポジウム
    • Place of Presentation
      名古屋
    • Year and Date
      2007-03-05
  • [Book] Current opinions regarding fish oils remedies in the near future( E. P. Heikkinen)2008

    • Author(s)
      Shuji Gamoh, Shahdat Md Hossain, Michio Hashimoto
    • Total Pages
      87-115
    • Publisher
      Nova Science Publishers, Inc., New York
  • [Remarks] DHA強化ソーセージによるヒト試験に関するインターネット・新聞報道

  • [Remarks] 中国新聞2010年3月1日

  • [Remarks] 水産タイムス2010年2月4日

  • [Remarks] 日刊水産通信2010年2月4日

  • [Remarks] 山陰中央新報2010年2月3日朝刊

  • [Remarks] みなと新聞2010年2月3日

  • [Remarks] 毎日新聞2010年2月3日夕刊第2面、朝刊第3面

  • [Remarks] ヤフートップニュース2010年2月3日青魚と認知症予防についてNHK総合テレビ2010年3月29日「ゆうどきネットワーク」(16:55~18:00、全国放送)で放映

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Published: 2011-06-18   Modified: 2016-04-21  

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