2009 Fiscal Year Final Research Report
MECHANISMS OF MODULATION OF LEARNING AND MEMORY FUNCTION BY NOCICEPTIN
| Project/Area Number |
19500333
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Meijo University |
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Principal Investigator |
HIRAMATSU Masayuki Meijo University, 薬学部, 准教授 (10189863)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 神経機能の可塑性 / ノシセプチン / 細胞内情報伝達系 / ペプチドフラグメント / nociceptin opioid peptide(NOP)受容体 / ERK / MEK経路 / 学習・記憶機能 / 抗認知症薬開発 |
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| Research Abstract |
Low doses of nociceptin attenuated the memory impairment, and this effect was not mediated via nociceptin opioid peptide receptors. We suggested that there is a novel action site or mechanism for these effects, and the sequence of nociceptin (14-17) is a critical structure.
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