2009 Fiscal Year Final Research Report
Bone abnormalities and unilateral eye deterioration in aspartate-glutamate carrier deficient mice
| Project/Area Number |
19500365
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory animal science
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| Research Institution | Kagoshima University |
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Principal Investigator |
IIJIMA Mikio Kagoshima University, 大学院・医歯学総合研究科, 助教 (00305111)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAGAWA Shirou 鹿児島大学, 大学院・医歯学総合研究科, 教授 (70073666)
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| Project Period (FY) |
2007 – 2009
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| Keywords | アスパラギン酸グルタミン酸輸送体 |
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| Research Abstract |
Aspartate-glutamate carrier deficient mice (citrin^<-/->, aralar^<+/-> mice) demonstrated growth retarded rate and bone abnomalities compared with their citrin-KO (citrin^<-/->, aralar^<+/+> mice) littermates. Citrin^<-/->, aralar^<+/-> mice fail to display hyperammonemia after oral administration of sucrose which is one of features of human type II citrullinemia model mice, citrin^<-/->, mGPDH^<-/-> mice. No citrin^<-/->, aralar^<+/-> mice which is suffer from unilateral eye deterioration demonstrated both eye aberrations up to 1 year.
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