OMRI resonator for imaging Systema digestorium diseases in animal

2008 Fiscal Year Final Research Report

• Project/Area Number: 19500391
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Biomedical engineering/Biological material science
• Research Institution: Kyushu University
• Principal Investigator: ICHIKAWA Kazuhiro Kyushu University, 大学院・薬学研究院, 准教授 (10271115)
• Co-Investigator(Renkei-kenkyūsha): YAMADA Ken-ichi 九州大学, 大学院・薬学研究院, 准教授 (60346806) ; YASUKAWA Keiji 九州大学, 大学院・薬学研究院, 助教 (80372738)
• Project Period (FY): 2007 – 2008
• Keywords: 医用・生体画像 / 生体レドックス

Research Abstract

本研究では、消化器疾患モデルのレドックス画像化を行うために、生体挿入可能な共振器の開発を行った。共振器方式、コーティング材料を検討した結果、高効率の超小型共振器の製作に成功した。本共振器の有効性は、疑似試料を用いて検証した。また、実験動物代表に挿入後、高感度の局所レドックス画像が得られた。以上の成果により、消化器疾患を対象とする挿入型小型共振器製作の要素技術を確立した。

Research Products

• [Journal Article] Analysis of in vivo redox status with magnetic resonance technique (2009)
  • Author(s): Ichikawa K, Yamada K, Yasukawa K, Utsumi H.
  • Journal Title: Yakugaku Zasshi.129 3 Pages: 273-8
• [Journal Article] Analysis of nitroxyl spin probes in mouse brain by X-band ESR with microdialysis technique (2008)
  • Author(s): Shiba T, Yamato M, Kudou W, Ichikawa K, Yamada K, Watanabe T, Utsumi H.
  • Journal Title: J Pharm Sci.97 4101-7 Pages: 9
• [Journal Article] Application of in vivo ESR/spin-probe technique to monitor tumor in vivo in mouse footpad (2007)
  • Author(s): Ichikawa K, Sakabe E, Kuninobu K, Yamori T, Tsuruo T, Yao T, Tsuneyoshi M, Utsumi H.
  • Journal Title: Antioxid Redox Signal. 9 10 Pages: 1699-707
• [Journal Article] Advantageous application of a surface coil to EPR irradiation in overhauser-enhanced MRI (2007)
  • Author(s): Matsumoto S, Yamada K, Hirata H, Yasukawa K, Hyodo F, Ichikawa K, Utsumi H.
  • Journal Title: Magn Reson Med57 4 Pages: 806-11
• [Presentation] 試料搬送型OMRI 装置における画像化アルゴリズム (2009)
  • Author(s): 市川和洋, 他
  • Organizer: 日本薬学会第129年会
  • Place of Presentation: 京都
  • Year and Date: 2009-03-27
• [Presentation] Imaging in vivo redox status in tumor using OMRI /nitroxyl spin probe technique (2008)
  • Author(s): Ichikawa K et.al.
  • Organizer: SFRBM2008
  • Place of Presentation: Indianapolis,USA
  • Year and Date: 2008-11-20
• [Presentation] Imaging in vivo redox status in tumor using OMRI /nitroxyl spin probe technique (2008)
  • Author(s): Ichikawa K et.al.
  • Organizer: EPR2008
  • Place of Presentation: Fukuoka
  • Year and Date: 2008-09-29
• [Presentation] 磁気共鳴法を用いた生体レドックス画像化 (2008)
  • Author(s): 市川和洋ほか
  • Organizer: 日本薬学会第128年会シンポジウム
  • Place of Presentation: 横浜
  • Year and Date: 2008-03-28
• [Presentation] Magnetic resonance imaging of in vivo redox status (2007)
  • Author(s): Ichikawa, K.. et.al.
  • Organizer: ISESS-SEST 2007
  • Place of Presentation: Shizuoka, Japan
  • Year and Date: 2007-11-07
• [Presentation] Pharmacodynamics of nitroxyl spin probes in in situ rodent liver perfusion system (2007)
  • Author(s): Ichikawa, K.. et.al.
  • Organizer: EPR2007
  • Place of Presentation: Chicago, USA
  • Year and Date: 2007-05-02
• [Presentation] Simultaneous molecular imaging technique of redox reactions monitored by Overhauser enhanced magnetic resonance imaging with nitroxyl radicals (2007)
  • Author(s): Ichikawa, K.. et.al.
  • Organizer: PSWC2007
  • Place of Presentation: Amsterdam, Nederland
  • Year and Date: 2007-04-25
• [Remarks]
  • URL: http://210.233.60.66/~kaiseki/