Biomarkers for the evaluation of lung remodeling using CT volume data

2009 Fiscal Year Final Research Report

• Project/Area Number: 19500421
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Medical systems
• Research Institution: Osaka University
• Principal Investigator: TOMIYAMA Noriyuki Osaka University, 医学系研究科, 准教授 (50294070)
• Co-Investigator(Kenkyū-buntansha): HONDA Osamu 大阪大学, 医学系研究科, 助教 (80324755) ; OGATA Yuji 大阪大学, 医学系研究科, 助教 (60281127)
• Project Period (FY): 2007 – 2009
• Keywords: 胸部CT / バイオマーカー / 肺リモデリング / 画像解析

Research Abstract

The purpose of this study is to find biomarkers for the evaluation of lung remodeling using CT volume data of lung focal volume and endobronchial volume. At first, we developed computer segmentation software to divide lung field into lobes for this purpose. Using this software lung focal volume and endobronchial volume were calculated and correlated with clinical findings and lung function tests. As a result, it was found that lung focal volume and endobronchial volume were increased in progression of obstructive lung disease, and these were decreased in progression of interstitial lung disease. It was suggested that these parameters could be robust biomarkers for the evaluation of lung remodeling in the clinical trial and routine clinical settings.

Research Products

• [Journal Article] Nonspecific interstitial pneumonia: histologic correlation with high-resolution CT in 29 patients. (2009)
  • Author(s): Sumikawa H, Johkoh T, Ichikado K, Taniguchi H, Kondoh Y, Fujimoto K, Yanagawa M, Inoue A, Mihara N, Honda O, Tomiyama N, Nakamura H, Colby TV.
  • Journal Title: Eur J Radiol. 70 Pages: 35-40
  • Peer Reviewed
• [Journal Article] Computed tomography findings in pathological usual interstitial pneumonia: relationship to survival. (2008)
  • Author(s): Sumikawa H, Johkoh T, Colby TV, Ichikado K, Suga M, Taniguchi H, Kondoh Y, Ogura T, Arakawa H, Fujimoto K, Inoue A, Mihara N, Honda O, Tomiyama N, Nakamura H, Muller NL.
  • Journal Title: Am. J. Respir.. Crit. Care. Med. 177 Pages: 433-439
  • Peer Reviewed
• [Journal Article] Pulmonary adenocarcinomas with ground-glass attenuation on thin-sectionCT: Quantification by three-dimensional image analyzing method. (2007)
  • Author(s): Sumikawa H, Johkoh T, Nagareda T, Sekiguchi J, Matsuo K, Fujita Y, Natsag J, Inoue A, Mihara N, Honda O, Tomiyama N, Minami M, Okumura M, Nakamura H.
  • Journal Title: Eur. J. Radiol. 65 Pages: 104-111
  • Peer Reviewed
• [Journal Article] Volume histogram analysis for lung thin-section computed tomography: differentiation between usual interstitial pneumonia and nonspecific interstitial pneumonia. (2007)
  • Author(s): Sumikawa H, Johkoh T, Yamamoto S, Oota M, Ueguchi T, Ogata Y, Matsumoto M, Fujita Y, Natsag J, Inoue A, Mihara N, Honda O, Tomiyama N, Nakamura H.
  • Journal Title: J. Comput. Assist. Tomogr. 31 Pages: 936-942
  • Peer Reviewed
• [Presentation] Pulmonary cysts, airway dimensions, respiratory functional abnormalities and prognosis; Quantitative analysis of volumetric CT data in 30 patients with lymphangioleiomyomatosis. (2009)
  • Author(s): Tobino K, Johkoh T, Seyama K, Kurihara M, Kikuyama A, Yanagawa M, Inoue A, Sumikawa H, Honda O, Koyama M, Yoshida S, Tomiyama N, Takahashi K.
  • Organizer: Radiological Society of North America 95th Scientific Assembly and Annual Meeting (RSNA'09)
  • Place of Presentation: Chicago, Illinoi, U.S.A.
  • Year and Date: 20091129-20091206
• [Presentation] 胸部volume CTの定量解析によるlymphangioleiomyomatosisの呼吸機能の評価. (2009)
  • Author(s): 飛野和則、上甲剛、田中悠子、瀬山邦明、富山憲幸、中村仁信、高橋和久
  • Organizer: 第1回呼吸機能イメージング研究会学術集会
  • Place of Presentation: 京都
  • Year and Date: 20090130-20090131
• [Presentation] 胸部volume CTの定量解析によるCOPDの呼吸機能の評価. (2009)
  • Author(s): 飛野和則、上甲剛、田中悠子、瀬山邦明、富山憲幸、中村仁信、高橋和久
  • Organizer: 第1回呼吸機能イメージング研究会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2009-01-30
• [Presentation] 肺のびまん性陰影におけるCTパターンのvolume histogramによる解析 (2008)
  • Author(s): 澄川裕充, 上甲剛, 梁川雅弘, 大門皇寿, 井上敦夫, 本多修, 吉田重幸, 富山憲幸, 中村仁信
  • Organizer: 第67回日本医学放射線学会学術発表会
  • Place of Presentation: 横浜
  • Year and Date: 2008-04-04
• [Presentation] Semi-automated segmentation of mediastinal lymph node stations from contrast-enhanced chest CT scans. (2007)
  • Author(s): Tanaka Y, Johkoh T, Watanabe S, Kusumoto M, Sato Y, Matsumoto M, Ogata Y, Tsuchiya R.
  • Organizer: American Thoracic Society International Conference(ATS'07)
  • Place of Presentation: San Francisco, California U.S. A
  • Year and Date: 2007-05-23