Histological analysis of the osteochondritis dissecans

2008 Fiscal Year Final Research Report

• Project/Area Number: 19500558
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Sports science
• Research Institution: Hirosaki University
• Principal Investigator: KUSUMI Tomomi Hirosaki University, 大学院・医学研究科, 講師 (90322932)
• Co-Investigator(Kenkyū-buntansha): ISHIBASHI Yasuyuki 弘前大学, 大学院・医学研究科, 准教授 (80292142) ; KUSUMI Akinori 弘前大学, 大学院・医学研究科, 客員研究員 (90332494) ; KIJIMA Hiroshi 弘前大学, 大学院・医学研究科, 教授 (90204859)
• Co-Investigator(Renkei-kenkyūsha): TSUDA Eiichi 弘前大学, 医学部附属病院, 講師 (00361014) ; SATO Fuyuki 弘前大学, 大学院・医学研究科, 助教 (60400131)
• Project Period (FY): 2007 – 2008
• Keywords: 関節疾患 / スポーツ医学 / 組織学 / 離断性骨軟骨炎

Research Abstract

離断性骨軟骨炎の罹患関節による病因・病態の相違を組織学的に検討した。手術を受けた肘・膝・足関節の病変部から採取された骨軟骨円柱標本を用いた。肘での分離は早期では関節軟骨深層で進行すると軟骨下骨が優位であった。軟骨・骨両方への微小外傷が主因と考えられた。膝は同様に微小外傷による変化と考えられるが、虚血性骨壊死像を呈する症例が少数あり、単一ではなく複合した病因と考えられた。足関節では軟骨損傷の関与は少なく、骨軟骨骨折の遷延が病因と考えられた。

Research Products

• [Journal Article] Passage-affected competitive regulation of osteoprotegerin synthesis and the receptor activator of nuclear factor-κB ligand mRNA expression in normal human osteoblasts stimulated by the application of cyclic tensile strain (2009)
  • Author(s): Kusumi T, Kusumi A, Miura A, Tateishi T.
  • Journal Title: J Bone Miner Metab (in press)
  • Peer Reviewed
• [Journal Article] 関節遊離体の臨床病理 : 離断性骨軟骨炎を中心に (2009)
  • Author(s): 楠美智巳, 津田英一, 石橋恭之, 楠美昭則, 鬼島宏
  • Journal Title: 病理と臨床 27(3) Pages: 275-282
• [Journal Article] Immunohistochemical detection of the carcinoma in the specimen obtained radial prostatectomy following hormone therapy (2008)
  • Author(s): Kusumi T, Koie T, Tanaka T, Matsumoto K, Sato F, Kusumi A, Ohyama C, Kijima H.
  • Journal Title: Pathol Int 58(11) Pages: 687-694
  • Peer Reviewed
• [Journal Article] Establishment of transplantable murine osteosarcoma cell line with endochondral ossification (2008)
  • Author(s): Nishi T, Kusumi T, Tanaka M, Sato F, Sasaki M, Kudo H, Kijima H.
  • Journal Title: Anticancer Res 28(3A) Pages: 1627-1631
  • Peer Reviewed
• [Journal Article] Locally administrated low-dose alendronate increases bone mineral density but bone strength during distraction osteogenesis in a rabbit model (2007)
  • Author(s): Omi H, Kusumi T, Kijima H, Toh S.
  • Journal Title: J Bone Joint Surg Br 89(7) Pages: 984-948
  • Peer Reviewed
• [Journal Article] Utility of immunohistochemical analysis for cyclooxygenase-2(COX-2)in the differential diagnosis of osteoblastoma and osteosarcoma (2007)
  • Author(s): Hosono A, Yamaguchi U, Makimoto A, Endo M, Watanabe A, Shimoda T, Kaya M, Mitsunori T, Sonobe H, Kusumi T, Yamaguchi T, Hasegawa T.
  • Journal Title: J Clin Pathol 60(4) Pages: 410-414
  • Peer Reviewed
• [Journal Article] Immunohistochemical demonstration of growth factors at the tendon-bone interface in anterior cruciate ligament reconstruction using a rabbit model (2007)
  • Author(s): Kohno T, Ishibashi Y, Tsuda E, Kusumi T, Tanaka M, Toh S.
  • Journal Title: J Orthop Sci 12(1) Pages: 67-73
  • Peer Reviewed