2010 Fiscal Year Final Research Report
Interaction of genetic and environmental factors in the development of life-style-related diseases.
| Project/Area Number |
19500602
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | University of Shizuoka |
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Principal Investigator |
KOBAYASHI Kimiko University of Shizuoka, 食品栄養科学部, 准教授 (90215319)
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| Co-Investigator(Kenkyū-buntansha) |
GODA Toshinao 静岡県立大学, 食品栄養科学部, 教授 (70195923)
ICHIKAWA Yoko 静岡県立大学, 食品栄養科学部, 准教授 (50269495)
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| Project Period (FY) |
2007 – 2010
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| Keywords | 生活習慣病 / 高血圧 / 糖尿病 / 肥満 / 遺伝要因 / 環境要因 |
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| Research Abstract |
The life-style-related diseases are caused by complex interactions among many different genes, and strongly influenced by environmental factors. We found that the interaction of variations in WNK1 and potassium intake are important for the prevalence of hypertension, and the interaction of variations in PEDX3 and fat intake for the prevalence of obesity. Furthermore, we found that the cumulative numbers of susceptibility alleles for diabetes were significantly higher in diabetic subjects than that of control subjects.
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