2009 Fiscal Year Final Research Report
Decrease in advanced glycation end-product (AGE) by short-term lifestyle modification in non-diabetic obese subjects
| Project/Area Number |
19500604
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Osaka City University |
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Principal Investigator |
FUJIMOTO Shigeo Osaka City University, 大学院・医学研究科, 教授 (90128752)
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIKAWA Takahiro 大阪市立大学, 大学院・医学研究科, 准教授 (10381998)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 肥満 / 終末糖化産物 / 動脈硬化 / 運動療法 |
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| Research Abstract |
Advanced glycation end products (AGEs) play an important role in development of atherosclerosis. There is currently little information available on the effects of lifestyle modification (LM) on circulating AGEs in obese subjects. Serum levels of Ne-(carboxymethyl) lysine (CML), pentosidine, derivatives of reactive oxygen metabolites (d-ROMs), and adipokines were determined in obese population. The present findings shows that number of steps in daily walking and decreases in body fat mass were significantly correlated with decrease in serum CML level. The study suggests the possibilities that the LM could be a promising approach to prevent the development of atherosclerotic diseases by reducing the AGEs formation.
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Research Products
(6 results)
