New approach for detoxication of toxic substances in foods and the evaluation

2009 Fiscal Year Final Research Report

• Project/Area Number: 19500675
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Eating habits, studies on eating habits
• Research Institution: National Institute of Health Sciences
• Principal Investigator: KONISHI Yoshiko National Institute of Health Sciences, 衛生微生物部, 部長 (10195761)
• Project Period (FY): 2007 – 2009
• Keywords: デトックス / 調理・加工 / 安全性 / カビ毒

Research Abstract

Mycotoxin is natural contaminant and cause adverse effects on human and animal health. Since it is too hard for mycotoxin to reach zero tolerance, many approachs to reduce intake mycotoxin from final food products have been tried. However the developed tools until now has advantages and disadvantages. Therefore the development of new method for reduction of exposure to mycotoxins is needed on food processing.
In this study, we developed pectin gelation containing mycotoxin (DON) and examined suppressive effect on absorption of deoxynivalenol (DON). As pectin, low methoxy non-amidate (LMNA) pectin and amidate (LMA) pectin were used. The gelation using LMA pectin was effective for sealing DON into gel at 4℃ and 37℃. In vivo experiment revealed that the gelation suppressed the absorption of DON in gastro-intestine.
The LMA pectin would be valuable processing tool to reduce the exposure to mycotoxin.

Research Products

• [Journal Article] A survey of the occurrence of Fusarium Mycotoxins in Biscuits in Japan by using LC/MS. (2010)
  • Author(s): Tanaka, H., Sugita-Konishi, Y., Takino, M., Tanaka, T., Toriba, A., Hayakawa, K.
  • Journal Title: J. Health Science 56(2) Pages: 1-7
  • Peer Reviewed
• [Journal Article] Determination of nivalenol and deoxynivalenol by liquid chromatography/atmospheric pressure photoionization mass spectrometry. (2009)
  • Author(s): Tanaka H, Takino M, Sugita-Konishi Y, Tanaka T, Toriba A, Hayakawa K.
  • Journal Title: Rapid Commun Mass Spectrom 23(19) Pages: 3119-3124
  • Peer Reviewed
• [Presentation] Suppressive Effect of Pectin Gelation on Absorption of Deoxynivalenol in Mice. (2010)
  • Author(s): Sugita-Konishi, Y., Koyama, D., Kadota, T., Itoh, S., Sugiyama, K., Tamura, C., Nishijima, M. Kamata, Y.
  • Organizer: 49th Annual Meeting of Society of Toxicology
  • Place of Presentation: 米国、ソルトレイク
  • Year and Date: 2010-03-10
• [Presentation] Suppressive Effect of Pectin Gelation on Absorption of Deoxynivalenol in Mice. (2009)
  • Author(s): Koyama, D., Arai, S., Kamata, Y., Nakajima, T., Sugita-Konishi, Y., Itoh, S.
  • Organizer: アジア養豚獣医学会(APVS2009)
  • Place of Presentation: 茨城県つくば市
  • Year and Date: 2009-10-27
• [Presentation] 低メトキシルペクチンのゲル化を利用したカビ毒の封入効果 (2009)
  • Author(s): 田村千佳子, 杉山圭一, 鎌田洋一, 小西良子, 中馬誠, 門田智之, 西島基弘
  • Organizer: 第98回日本食品衛生学会
  • Place of Presentation: 函館
  • Year and Date: 2009-10-08
• [Presentation] Sealing effects of pectin gelation on mycotoxin reduction in food (2009)
  • Author(s): Tamura, C., Nakamura, M., Kadota, T., Itoh, S., Kamata, Y., Sugiyama, K., Nishijima, N., Sugita-Konishi, Y
  • Organizer: ISM Conference 2009
  • Place of Presentation: ツーリン、オーストリア
  • Year and Date: 2009-09-08
• [Patent(Industrial Property Rights)] マイコトキシンの体内への吸収を抑制する効果のある食品または飼料用添加剤 (2009)
  • Inventor(s): 小西良子田村千佳子中馬誠
  • Industrial Property Rights Holder: 国立医薬品食品衛生研究所三栄源ffi(株)
  • Industrial Property Number: 特願・2009-207488
  • Filing Date: 2009-09-08
  • Acquisition Date: 2009-09-08