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2009 Fiscal Year Final Research Report

Health effect evaluation based on characteristics of nanoparticles

Research Project

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Project/Area Number 19510036
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Environmental impact assessment/Environmental policy
Research InstitutionKurume University

Principal Investigator

ISHIHARA Yoko  Kurume University, 医学部, 教授 (50203021)

Co-Investigator(Kenkyū-buntansha) HAGIWARA Hiromi  横浜桐蔭大学, 医用工学部, 教授 (90189465)
ARAI Masataka  群馬大学, 工学部, 教授 (80112176)
TANAKA Eiichiro  久留米大学, 医学部, 教授 (80188284)
HASEGAWA Go  久留米大学, 医学部, 助教 (80383751)
KOYAMA Satoshi  久留米大学, 医学部, 助教 (10549637)
NISHI Yoshihiro  久留米大学, 医学部, 講師 (20352122)
MURAI Yoshinaka  久留米大学, 医学部, 准教授 (40322820)
Project Period (FY) 2007 – 2009
Keywords健康影響評価 / ナノ粒子 / ナノマテリアル / ナノテクノロジー / 神経作用 / ミクログリア / アストロサイト
Research Abstract

This experiment was conducted to clarify the appropriate assessment for health effect based on the nanoparticles characteristics with emphasis on neurological effects. 1. Nanopariticles incorporated into the olfactory bulb and brain tissue is highly relevant astrocytes and micoglia cells rather than neurons. Nanoparticles may be immediately taken up by phagocyte cells and clearance in the local. Therefore, the safety evaluation of nanoparticles is necessary to examine in the olfactory bulb and/or brain as well as the heart and lung. 2. The pharmacokinetics of nanoparticles may be affected by the chemical characteristics and the physical properties. 3. The safety evaluation of nanomaterials needs to test fully the toxicity on organ metabolism in vivo experiment. In conclusion, the health assessment of nanoparticles must be evaluated by both in vitro and in vivo studies based on its chemical and physical characteristics, and requiring the establishment of a new test methods including evaluation of toxicity in the nerve tissues.

  • Research Products

    (13 results)

All 2010 2009 2008 2007

All Journal Article (6 results) (of which Peer Reviewed: 4 results) Presentation (3 results) Book (4 results)

  • [Journal Article] 層流拡散火炎内におけるPAHおよびPMの生成挙動2009

    • Author(s)
      仲村卓人, 新井雅隆, (他2)
    • Journal Title

      日本機械学会 75

      Pages: 1363-70

    • Peer Reviewed
  • [Journal Article] プール燃焼方式のPM発生装置により生成される粒子状物質の特性2009

    • Author(s)
      山本知恵美, 新井雅隆, (他2)
    • Journal Title

      日本機械学会 75

      Pages: 1182-89

    • Peer Reviewed
  • [Journal Article] プロパンの層流拡散火炎内におけるPAH生成挙動2009

    • Author(s)
      小林佳弘, 新井雅隆
    • Journal Title

      日本機械学会 75

      Pages: 184-191

    • Peer Reviewed
  • [Journal Article] Effects of alkylphenols on bone metabolism in vivo and in vitro2008

    • Author(s)
      Hagiwara H, Ishihara Y, (他3)
    • Journal Title

      Toxicol Lett 181

      Pages: 13-18

    • Peer Reviewed
  • [Journal Article] 微小粒子状物質と心肺疾患2008

    • Author(s)
      石原陽子、柴田彰、長谷川豪
    • Journal Title

      呼吸と循環 56

      Pages: 817-826

  • [Journal Article] 有害大気汚染物質の計測技術自動車研究2008

    • Author(s)
      新井雅隆
    • Journal Title

      30

      Pages: 1-4

  • [Presentation] Safety evaluation of fullerene nanowhisker as a new nanoproduct-in vitro experiment.2010

    • Author(s)
      Koyama S, Hasegawa G, Ishihara Y
    • Organizer
      ociety for Toxicology Annual Meeting & ToxExpo
    • Place of Presentation
      Salt Lake City, USA
    • Year and Date
      20100300
  • [Presentation] Effect of Sulfur Content in Liquid Fuel on Particles in a Flue. Gas Exhausted from Spray Combustion Furnace2009

    • Author(s)
      Y. Wu, M. Arai, (他2)
    • Organizer
      The 13th Annual Confernce on Liauid Atoization and Spray Systems-Asia
    • Place of Presentation
      Wuxi, P.R. China
    • Year and Date
      20091015-20091017
  • [Presentation] Behavior of PAHs and PM in a Diffusion Flame of Diesel Fuel2008

    • Author(s)
      Y Kobayashi, K Amagai, T Furuhata、M Arai
    • Organizer
      The Seventh International Conference on Modeling and Diagnostics for Advanced Engine Systms
    • Place of Presentation
      Sapporo Japan
    • Year and Date
      20080628-20080631
  • [Book] 第2章ナノ材料の生体への影響5. ナノ粒子の体内への取り込み経路、標的となる臓器とその影響ナノ材料のリスク評価と安全性対策2010

    • Author(s)
      石原陽子、長谷川豪、小山哲史
    • Publisher
      フロンティア出版(印刷中)
  • [Book] 粒子状物質計測に関する全体動向(最新の粒子状物質計測手法)2009

    • Author(s)
      新井雅隆
    • Total Pages
      1-10
    • Publisher
      日本機械学会
  • [Book] ナノ粒子・微小粒子の体内への侵入と体内移行メカニズム2007

    • Author(s)
      石原陽子
    • Total Pages
      43-58
    • Publisher
      技術情報協会(東京)
  • [Book] 酸化チタン. ナノ粒子の有害性評価とリスク対策2007

    • Author(s)
      石原陽子
    • Total Pages
      416-430
    • Publisher
      技術情報協会(東京)

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Published: 2011-06-18   Modified: 2016-04-21  

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